WADA (West Africa Database on Antiretroviral Therapy) Collaboration

WADA（西非抗逆转录病毒治疗数据库）合作

• 批准号: 7118355
• 负责人: Francois Dabis
• 金额: $ 80.66万
• 依托单位: UNIVERSITY OF BORDEAUX II
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118355
• 关键词: Africa; children; clinical research; experience; information systems; motivation

DESCRIPTION (provided by applicant): The WADA (West Africa Data Base on Antiretroviral Therapy) Collaboration is a unique collaboration among cohorts in West Africa with a mission to conduct hypothesis-driven epidemiological research on the prognosis and outcome of HIV type 1 and 2-infected people, including adults, pregnant mothers, and children. The research will focus on scientific questions requiring a large sample size of patients which the contributing cohorts cannot answer individually and which do not overlap with existing projects. Activities during Year 1 will focus on cross-sectional analyses of existing data, a comprehensive examination of the available data in terms of completeness of core items at baseline and during follow-up, and the development of instruments to standardize, harmonize and improve data collection across sites. The research agenda and specific hypotheses for Years 2-5 will be finalized based on the results of Year 1 activities, with a focus on the following four areas: programmatic issues (access to ant- retroviral treatment and losses to follow up); monitoring and outcomes of treatment in adults, children and pregnant women; clinical response, with a special interest for tuberculosis, opportunistic infections, immune reconstitution syndrome and hepatitis B coinfection; care of HIV-2 infection. Additional research questions will be focused in the subsequent years, with the expectation to address around 30 completed projects and analyses over five years. A total of 17 cohorts in six major cities in six West African countries - each ongoing and with their own internal governance structure and financial support - have agreed to contribute data collected already over the past years from a collective number of 2,345 HIV-infected children and 33,245 adult patients. The regional coordinating centre for this application will be located in Bordeaux, France. This university team (Prof Francois Dabis, ISPED, Universite Victor Segalen) has a long lasting experience in epidemiological HIV cohort research in West Africa, with an office in Abidjan, Cote d'lvoire. It also has extensive experience with international collaborations of this kind including the Ghent Group on HIV in Women and Children and the ART-LINC Collaboration. ISPED will be responsible for the implementation of the WADA Collaboration. Data will be collected from affiliated cohorts every year and once merged into a main WADA database, data extracts will be made for the various projects and analyses. This process will be repeated annually allowing for the analysis of the most contemporary data collected in the affiliated cohorts. WADA is an unprecedented undertaking in West Africa, with a unique design, lead by investigators with extensive experience, that will advance the public health knowledge required to better understand and treat HIV-infected persons of all ages, genders and backgrounds in sub-Saharan Africa, the continent with the largest unmet needs but with onqoing, rapid and massive roll-out of HIV treatment programmes.

描述（由申请人提供）：WADA（西非抗逆转录病毒治疗数据库）合作是西非群体之间的一项独特合作，其使命是对 HIV 1 型和 2 型感染者（包括成人、孕妇和儿童）的预后和结果进行假设驱动的流行病学研究。该研究将重点关注需要大量患者样本的科学问题，而贡献队列无法单独回答这些问题，并且与现有项目不重叠。第一年的活动将侧重于现有数据的横断面分析，在基线和后续过程中对现有数据的完整性进行全面检查，以及开发标准化、协调和改进跨站点数据收集的工具。第 2-5 年的研究议程和具体假设将根据第 1 年活动的结果最终确定，重点关注以下四个领域： 规划问题（获得抗逆转录病毒治疗的机会和后续损失）；成人、儿童和孕妇的治疗监测和结果；临床反应，特别关注结核病、机会性感染、免疫重建综合征和乙型肝炎合并感染； HIV-2 感染的护理。未来几年将重点关注其他研究问题，预计在五年内解决约 30 个已完成的项目和分析。六个西非国家六个主要城市的总共 17 个队列（每个队列均正在进行中，并拥有自己的内部治理结构和财务支持）已同意贡献过去几年从 2,345 名艾滋病毒感染儿童和 33,245 名成年患者中收集的数据。该申请的区域协调中心将设在法国波尔多。该大学团队（Victor Segalen 大学 ISPED 的 Francois Dabis 教授）在西非艾滋病流行病学队列研究方面拥有长期的经验，在科特迪瓦阿比让设有办事处。它还在此类国际合作方面拥有丰富的经验，包括根特妇女和儿童艾滋病毒小组和 ART-LINC 合作。 ISPED 将负责 WADA 合作的实施。每年都会从附属队列收集数据，一旦合并到世界反兴奋剂机构的主数据库中，将为各个项目和分析提取数据。这一过程将每年重复一次，以便对附属队列中收集的最新数据进行分析。世界反兴奋剂机构在西非是一项史无前例的事业，其设计独特，由经验丰富的调查人员领导，将提高公众健康知识，以更好地了解和治疗撒哈拉以南非洲各个年龄、性别和背景的艾滋病毒感染者。撒哈拉以南非洲是未满足需求最多的大陆，但艾滋病毒治疗计划正在迅速、大规模地推广。