Harvard Older Americans Independence Center Grant

哈佛大学美国老年人独立中心拨款

• 批准号: 7793863
• 负责人: LEWIS LIPSITZ
• 金额: $ 19.44万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793863
• 关键词: Harvard; Older; Americans; Independence; Center

DESCRIPTION (provided by applicant): This is the second revision of our application to renew the Harvard Older Americans Independence Center (OAIC), which was previously funded by a P60 mechanism for 15 years. Over the past funding cycle our research has shown important relationships between cardiovascular risk factors, the development of cerebral and systemic microvascular disease, and the ultimate development of impaired cognitive and physical functions in older adults. Building on these observations, our renewal will focus on the vascular role In age related functional loss. The overarching goal of the new Harvard OAIC is to strengthen and expand our expertise, scientific resources, and translational research at the interface of vascular medicine and gerontology in order to enhance our understanding of the vascular role in age-related physical and cognitive functional decline, design new interventions to ameliorate this decline, and train new investigators to become skilled in this important area of research. To achieve this goal we are proposing a Research Career Development Core (RCDC) led by Drs. Edward Marcantonio and Murray Mittleman; a Pilot/Exploratory Studies Core (PESC) led by Drs. Douglas Kiel and Anthony Rosenzweig; a Leadership and Administration Core (LAC) led by Drs. Lewis Lipsitz and Peter Oettgen; and 3 Resource Cores, including: 1) Clinical Research and Recruitment, led by Dr. Lewis Lipsitz; 2) Advanced Statistics and Psychometrics led by Drs. Richard Jones and Adrienne Cupples; and 3) Physiologic Measurement and Biomarkers led by Dr. Vera Novak. For the RCDC, PESC, and LAC we have created leadership pairs who bring expertise in vascular biology, aging, and mentoring to our OAIC. Dr. Lipsitz Professor of Medicine and founding member of the Harvard OAIC, will continue to serve as principal investigator. After a formal solicitation and review process, we selected 3 RCD, 3 pilot, 2 small pilot, and 12 external projects for support. These are closely allied with our theme, have strong potential for future funding address knowledge gaps in our conceptual model, and bring new expertise to our Pepper Center in endothelial precursor cell biology, adipokine and obesity research, retinal vascular image analysis, endothelial function measurement, renin angiotensin physiology, proteomics, informatics, and nonlinear analysis of dynamic cardiovascular signals. The Harvard OAIC will bring faculty members together for research seminars, cultural competence training, and scientific suppers, and will foster the career development of a diverse group of new scientists who are dedicated to translational research in vascular aging. Our strong institutional commitments, outstanding faculty, extensive resources, and pipeline of talented trainees and junior faculty will help ensure we meet our goals. PUBLIC HEALTH RELEVANCE: Aging is one of the major risk factors for vascular diseases such as coronary heart disease, heart failure, and stroke, which are leading causes of death and disability in elderly people. The Harvard OAIC will strengthen and expand our knowledge and scientific resources in vascular medicine and aging to help us better understand the vascular role in age-related physical and cognitive decline, design new interventions to ameliorate this decline, and train new investigators to study this critical problem.

描述（由申请人提供）：这是我们申请更新哈佛老年美国人独立中心（OAIC）的第二次修订，该中心以前由P60机制资助15年。在过去的资助周期中，我们的研究显示了心血管风险因素，脑和全身微血管疾病的发展以及老年人认知和身体功能受损的最终发展之间的重要关系。基于这些观察，我们的更新将集中在血管在年龄相关的功能丧失中的作用。新的哈佛OAIC的总体目标是加强和扩大我们的专业知识，科学资源，并在血管医学和老年学的接口转化研究，以提高我们对血管在年龄相关的身体和认知功能下降的作用的理解，设计新的干预措施，以改善这种下降，并培训新的研究人员成为熟练的研究这一重要领域。为了实现这一目标，我们提出了由Edward Marcantonio博士和Murray Mittleman博士领导的研究职业发展核心（RCDC）;由道格拉斯基尔博士和Anthony Rosenzweig博士领导的试点/探索性研究核心（PESC）;由刘易斯Lipsitz博士和Peter Oettgen博士领导的领导和管理核心（LAC）;以及3个资源核心，包括：1）由刘易斯Lipsitz博士领导的临床研究和招募; 2）由Richard Jones和Adrienne Cupples博士领导的高级统计学和心理测量学;以及3）由Vera Novak博士领导的生理测量和生物标志物。对于RCDC、PESC和LAC，我们创建了领导对，他们将血管生物学、老化和指导方面的专业知识带到我们的OAIC。Lipsitz博士是医学教授，也是哈佛OAIC的创始成员，他将继续担任首席研究员。经过正式的征求和审查过程，我们选择了3个RCD，3个试点项目，2个小型试点项目和12个外部项目进行支持。这些都与我们的主题密切相关，有很强的潜力，未来的资金解决知识差距，在我们的概念模型，并带来新的专业知识，我们的辣椒中心在内皮前体细胞生物学，脂肪因子和肥胖研究，视网膜血管图像分析，内皮功能测量，肾素血管紧张素生理学，蛋白质组学，信息学和非线性分析的动态心血管信号。该哈佛OAIC将带来教师一起研究研讨会，文化能力培训，科学晚餐，并将促进谁是致力于血管老化的转化研究的新科学家的多元化群体的职业发展。我们强大的机构承诺，优秀的教师，广泛的资源，以及有才华的学员和初级教师的管道将有助于确保我们实现我们的目标。 公共卫生相关性：老龄化是冠心病、心力衰竭和中风等血管疾病的主要危险因素之一，这些疾病是老年人死亡和残疾的主要原因。哈佛OAIC将加强和扩大我们在血管医学和衰老方面的知识和科学资源，帮助我们更好地了解血管在与年龄相关的身体和认知能力下降中的作用，设计新的干预措施来改善这种下降，并培训新的研究人员来研究这一关键问题。