Harvard Older Americans Independence Center Grant

哈佛大学美国老年人独立中心拨款

• 批准号: 7793863
• 负责人: LEWIS LIPSITZ
• 金额: $ 19.44万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793863
• 关键词: Harvard; Older; Americans; Independence; Center

DESCRIPTION (provided by applicant): This is the second revision of our application to renew the Harvard Older Americans Independence Center (OAIC), which was previously funded by a P60 mechanism for 15 years. Over the past funding cycle our research has shown important relationships between cardiovascular risk factors, the development of cerebral and systemic microvascular disease, and the ultimate development of impaired cognitive and physical functions in older adults. Building on these observations, our renewal will focus on the vascular role In age related functional loss. The overarching goal of the new Harvard OAIC is to strengthen and expand our expertise, scientific resources, and translational research at the interface of vascular medicine and gerontology in order to enhance our understanding of the vascular role in age-related physical and cognitive functional decline, design new interventions to ameliorate this decline, and train new investigators to become skilled in this important area of research. To achieve this goal we are proposing a Research Career Development Core (RCDC) led by Drs. Edward Marcantonio and Murray Mittleman; a Pilot/Exploratory Studies Core (PESC) led by Drs. Douglas Kiel and Anthony Rosenzweig; a Leadership and Administration Core (LAC) led by Drs. Lewis Lipsitz and Peter Oettgen; and 3 Resource Cores, including: 1) Clinical Research and Recruitment, led by Dr. Lewis Lipsitz; 2) Advanced Statistics and Psychometrics led by Drs. Richard Jones and Adrienne Cupples; and 3) Physiologic Measurement and Biomarkers led by Dr. Vera Novak. For the RCDC, PESC, and LAC we have created leadership pairs who bring expertise in vascular biology, aging, and mentoring to our OAIC. Dr. Lipsitz Professor of Medicine and founding member of the Harvard OAIC, will continue to serve as principal investigator. After a formal solicitation and review process, we selected 3 RCD, 3 pilot, 2 small pilot, and 12 external projects for support. These are closely allied with our theme, have strong potential for future funding address knowledge gaps in our conceptual model, and bring new expertise to our Pepper Center in endothelial precursor cell biology, adipokine and obesity research, retinal vascular image analysis, endothelial function measurement, renin angiotensin physiology, proteomics, informatics, and nonlinear analysis of dynamic cardiovascular signals. The Harvard OAIC will bring faculty members together for research seminars, cultural competence training, and scientific suppers, and will foster the career development of a diverse group of new scientists who are dedicated to translational research in vascular aging. Our strong institutional commitments, outstanding faculty, extensive resources, and pipeline of talented trainees and junior faculty will help ensure we meet our goals. PUBLIC HEALTH RELEVANCE: Aging is one of the major risk factors for vascular diseases such as coronary heart disease, heart failure, and stroke, which are leading causes of death and disability in elderly people. The Harvard OAIC will strengthen and expand our knowledge and scientific resources in vascular medicine and aging to help us better understand the vascular role in age-related physical and cognitive decline, design new interventions to ameliorate this decline, and train new investigators to study this critical problem.

描述(申请人提供)：这是我们对哈佛老年美国人独立中心(OAIC)续签申请的第二次修订，该中心之前是由P60机制资助15年的。在过去的资金周期中，我们的研究表明，心血管风险因素、脑部和全身微血管疾病的发展，以及老年人认知和身体功能受损的最终发展之间存在重要的关系。在这些观察的基础上，我们的更新将侧重于血管在年龄相关性功能丧失中的作用。新的哈佛OAIC的总体目标是加强和扩大我们在血管医学和老年学方面的专业知识、科学资源和转化研究，以增强我们对血管在与年龄相关的身体和认知功能下降中的作用的理解，设计新的干预措施来改善这种下降，并培训新的研究人员，使其在这一重要研究领域变得熟练。为了实现这一目标，我们提议成立一个研究职业发展核心(RCDC)，由Edward Marcantonio博士和Murray Mittleman博士领导；一个试点/探索性研究核心(PESC)，由Douglas Kiel博士和Anthony Rosenzweig博士领导；一个领导力和管理核心(LAC)，由Lewis Lipsitz博士和Peter Oettgen博士领导；以及3)资源核心，包括：1)临床研究和招聘，由Lewis Lipsitz博士领导；2)高级统计学和心理测量学，由Richard Jones博士和Adrienne Cupples博士领导；以及3)生理学测量和生物标志物，由Vera Novak博士领导。对于RCDC、PESC和LAC，我们已经建立了领导对，他们为我们的OAIC带来了血管生物学、老龄化和指导方面的专业知识。利普西茨博士，医学教授和哈佛大学OAIC的创始成员，将继续担任首席研究员。经过正式的征集和审查过程，我们选择了3个RCD项目、3个试点项目、2个小型试点项目和12个外部项目作为支持。这些与我们的主题密切相关，具有强大的未来资金潜力，可以解决我们概念模型中的知识空白，并为我们的胡椒中心带来新的专业知识，包括内皮前体细胞生物学、脂肪因子和肥胖研究、视网膜血管图像分析、内皮功能测量、肾素血管紧张素生理学、蛋白质组学、信息学和动态心血管信号的非线性分析。哈佛OAIC将把教职员工聚集在一起，参加研究研讨会、文化能力培训和科学晚餐，并将促进致力于血管衰老转化性研究的多元化新科学家群体的职业发展。我们坚定的机构承诺、优秀的教员、广泛的资源以及有才华的实习生和初级教员将有助于确保我们实现目标。 公共卫生相关性：老龄化是冠心病、心力衰竭和中风等血管疾病的主要危险因素之一，这些疾病是老年人死亡和残疾的主要原因。哈佛OAIC将加强和扩大我们在血管医学和衰老方面的知识和科学资源，以帮助我们更好地了解血管在与年龄相关的身体和认知下降中的作用，设计新的干预措施来改善这种下降，并培训新的研究人员来研究这一关键问题。