Genomics Alcohol Research Core

基因组酒精研究核心

• 批准号: 7858949
• 负责人: ROBERT J. HITZEMANN
• 金额: $ 46.2万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7858949
• 关键词: Address; Affect; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Am 80; Animals; Applications Grants; Appointment; Area; Behavioral; Bioinformatics; Biological; Biomedical Research; Biometry; Blood alcohol level measurement; Brain; Center Core Grants; Chronic; Communities; Consumption; Coupled; Data; Development; Drug abuse; Educational process of instructing; Emerging Technologies; Experimental Designs; Faculty; Funding; Gene Expression; Genes; Genetic Models; Genetic Polymorphism; Genomics; Goals; Grant; Individual; Joints; Liver; Macaca mulatta; Medical Genetics; Medical Informatics; Modeling; Molecular; Monkeys; Mus; National Institute on Alcohol Abuse and Alcoholism; Needs Assessment; Network-based; Neurosciences; Oregon; Pancreas; Positioning Attribute; Primates; Problem Solving; Protocols documentation; Quantitative Trait Loci; Recovery; Recruitment Activity; Regulation; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Self Administration; Services; Substance abuse problem; System; Techniques; Testing; Tissues; United States National Institutes of Health; Universities; Wages; alcohol exposure; alcohol research; biological systems; brain tissue; clinical epidemiology; interest; medical schools; multidisciplinary; next generation; nonhuman primate; professor; programs; public health relevance; ranpirnase; repository; response; skills

DESCRIPTION (provided by applicant): The following grant application is submitted in response to RFA-OD-09-005 (Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers [P30]). We believe that the application is responsive to the RFA In that we seek to hire, provide appropriate start-up packages and develop pilot research projects for newly-independent investigators, with the goal of augmenting and expanding OHSU's community of multidisciplinary researchers focusing on areas of biomedical research relevant to NIH. This P30 focuses on a Bioinformatics Core with the goal of recruiting individual(s) with interests in alcohol and drug abuse coupled with interests in mouse and non-human primate genomics. The emphasis on alcohol and drug abuse aligns with the interests and grant portfolio of the applicant department - Behavioral Neuroscience. Thus, we feel the application is best directed to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The primary partner in this application, the Oregon National Primate Research Center (ONPRC) supports this alignment; here we note the relatively recent joint hiring (Behavioral Neuroscience and the ONPRC) of Dr Kathy Grant, a leading expert on primate models of alcohol abuse and a collaborator on this application. However, we (Behavioral Neuroscience and the ONPRC) view the indlvidual(s) recruited through the P30 mechanism as also having a larger role in developing bioinformatic resources at OHSU. The bulk of the P30 funding will be used to help recruit junior faculty and to develop a pilot research program. The successful applicant(s) will be appointed as an Assistant Professor in the Department of Behavioral Neuroscience (tenure track) and as a Staff Scientist at the ONPRC, with joint appointments in the Departments of Molecular & Medical Genetics and Medical Informatics and Clinical Epidemiology. The successful applicant(s) for the position within the Core will be individual(s) with expertise in a field we have termed "systems bioinformatics". The intent of using this term is that we will recruit an individual not only with the analytical skills to effectively utilize emerging technologies such as mRNAseq or ChiPseq but also with interests in solving problems related to the Center. PUBLIC HEALTH RELEVANCE: The Core Center supported by the P30 mechanism will be used to recruit new faculty to study from a biological perspective, alcohol abuse and alcoholism. The research will involve initially the use of sophisticated analytical approaches to study gene expression in brain and other tissues affected by chronic alcohol exposure. The goal is to detect the underlying pathological mechanisms.

描述（由申请人提供）：以下授予申请是针对RFA-OD-09-005（恢复ACT Limited竞争：支持新的教师招聘，以通过生物医学研究核心中心增强研究资源[P30]）。我们认为，该应用程序对RFA有响应，因为我们寻求雇用，提供适当的启动套餐并为新独立的研究人员开发试点研究项目，目的是扩大和扩展OHSU的多学科研究人员社区，重点关注与NIH相关的生物医学研究领域。该P30的重点是生物信息学核心，其目的是招募个人对酒精和药物滥用的兴趣以及对小鼠和非人类灵长类动物基因组学的兴趣。对酒精和药物滥用的强调与申请人部门的利益和赠款组合相吻合 - 行为神经科学。因此，我们认为该申请最好针对美国国家酒精滥用和酒精中毒研究所（NIAAA）。俄勒冈州国家灵长类动物研究中心（ONPRC）的主要合作伙伴支持此一致性；在这里，我们注意到凯西·格兰特（Kathy Grant）博士的相对较新的联合招聘（行为神经科学和ONPRC）是灵长类动物滥用酗酒的领先专家，也是该应用程序的合作者。但是，我们（行为神经科学和ONPRC）查看通过P30机制募集的印象（S）在OHSU开发生物信息学资源方面也具有更大的作用。 P30资金的大部分将用于帮助招募初级教师并制定试点研究计划。成功的申请人将被任命为行为神经科学系（任期）的助理教授，以及ONPRC的一名参谋科学家，分子与医学遗传学以及医学信息学和临床流行病学的联合任命。在核心内部职位的成功申请人将是个人，在我们称为“系统生物信息学”的领域中具有专业知识。使用该术语的目的是，我们将不仅招募一个具有分析能力的人，以有效利用MRNASEQ或CHIPSEQ等新兴技术，而且对解决与中心有关的问题有兴趣。 公共卫生相关性：由P30机制支持的核心中心将用于招募新教师，以从生物学的角度，酗酒和酒精中毒研究。这项研究最初将涉及使用复杂的分析方法研究大脑和其他受长期酒精暴露影响的组织中的基因表达。目的是检测潜在的病理机制。