Genomics Alcohol Research Core

基因组酒精研究核心

• 批准号: 7858949
• 负责人: ROBERT J. HITZEMANN
• 金额: $ 46.2万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7858949
• 关键词: Address; Affect; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Am 80; Animals; Applications Grants; Appointment; Area; Behavioral; Bioinformatics; Biological; Biomedical Research; Biometry; Blood alcohol level measurement; Brain; Center Core Grants; Chronic; Communities; Consumption; Coupled; Data; Development; Drug abuse; Educational process of instructing; Emerging Technologies; Experimental Designs; Faculty; Funding; Gene Expression; Genes; Genetic Models; Genetic Polymorphism; Genomics; Goals; Grant; Individual; Joints; Liver; Macaca mulatta; Medical Genetics; Medical Informatics; Modeling; Molecular; Monkeys; Mus; National Institute on Alcohol Abuse and Alcoholism; Needs Assessment; Network-based; Neurosciences; Oregon; Pancreas; Positioning Attribute; Primates; Problem Solving; Protocols documentation; Quantitative Trait Loci; Recovery; Recruitment Activity; Regulation; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Self Administration; Services; Substance abuse problem; System; Techniques; Testing; Tissues; United States National Institutes of Health; Universities; Wages; alcohol exposure; alcohol research; biological systems; brain tissue; clinical epidemiology; interest; medical schools; multidisciplinary; next generation; nonhuman primate; professor; programs; public health relevance; ranpirnase; repository; response; skills

DESCRIPTION (provided by applicant): The following grant application is submitted in response to RFA-OD-09-005 (Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers [P30]). We believe that the application is responsive to the RFA In that we seek to hire, provide appropriate start-up packages and develop pilot research projects for newly-independent investigators, with the goal of augmenting and expanding OHSU's community of multidisciplinary researchers focusing on areas of biomedical research relevant to NIH. This P30 focuses on a Bioinformatics Core with the goal of recruiting individual(s) with interests in alcohol and drug abuse coupled with interests in mouse and non-human primate genomics. The emphasis on alcohol and drug abuse aligns with the interests and grant portfolio of the applicant department - Behavioral Neuroscience. Thus, we feel the application is best directed to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The primary partner in this application, the Oregon National Primate Research Center (ONPRC) supports this alignment; here we note the relatively recent joint hiring (Behavioral Neuroscience and the ONPRC) of Dr Kathy Grant, a leading expert on primate models of alcohol abuse and a collaborator on this application. However, we (Behavioral Neuroscience and the ONPRC) view the indlvidual(s) recruited through the P30 mechanism as also having a larger role in developing bioinformatic resources at OHSU. The bulk of the P30 funding will be used to help recruit junior faculty and to develop a pilot research program. The successful applicant(s) will be appointed as an Assistant Professor in the Department of Behavioral Neuroscience (tenure track) and as a Staff Scientist at the ONPRC, with joint appointments in the Departments of Molecular & Medical Genetics and Medical Informatics and Clinical Epidemiology. The successful applicant(s) for the position within the Core will be individual(s) with expertise in a field we have termed "systems bioinformatics". The intent of using this term is that we will recruit an individual not only with the analytical skills to effectively utilize emerging technologies such as mRNAseq or ChiPseq but also with interests in solving problems related to the Center. PUBLIC HEALTH RELEVANCE: The Core Center supported by the P30 mechanism will be used to recruit new faculty to study from a biological perspective, alcohol abuse and alcoholism. The research will involve initially the use of sophisticated analytical approaches to study gene expression in brain and other tissues affected by chronic alcohol exposure. The goal is to detect the underlying pathological mechanisms.

描述（由申请人提供）：以下拨款申请是根据RFA-OD-09-005（恢复法案有限竞争：支持新教师招聘，通过生物医学研究核心中心增加研究资源[P30]）提交的。我们认为该申请是对RFA的回应，因为我们寻求雇用，提供适当的启动包，并为新独立的研究人员开发试点研究项目，目的是扩大OHSU的多学科研究人员社区，重点关注与NIH相关的生物医学研究领域。本P30重点关注生物信息学核心，目标是招募对酒精和药物滥用感兴趣以及对小鼠和非人类灵长类基因组学感兴趣的个人。对酒精和药物滥用的重视与申请部门-行为神经科学的兴趣和资助组合一致。因此，我们认为申请最好直接提交给国家酒精滥用和酒精中毒研究所（NIAAA）。在这个应用程序的主要合作伙伴，俄勒冈国家灵长类动物研究中心（ONPRC）支持这一对齐；在这里，我们注意到最近联合聘用（行为神经科学和ONPRC）的凯西·格兰特博士，他是研究酒精滥用灵长类动物模型的主要专家，也是该应用程序的合作者。然而，我们（行为神经科学和ONPRC）认为通过P30机制招募的个体在OHSU开发生物信息资源方面也发挥着更大的作用。P30项目的大部分资金将用于帮助招募初级教师和开发一个试点研究项目。成功申请者将被任命为行为神经科学部门的助理教授（终身制）和ONPRC的专职科学家，并在分子与医学遗传学、医学信息学和临床流行病学部门联合任命。核心职位的成功申请者将是在我们称之为“系统生物信息学”领域具有专业知识的个人。使用这一术语的目的是，我们招聘的个人不仅具有分析技能，能够有效地利用新兴技术，如mRNAseq或ChiPseq，而且对解决与中心相关的问题感兴趣。