Vaccination design based on natural env genes to elicit broad neutralizing Abs

基于天然 env 基因的疫苗设计可引发广泛的中和抗体

• 批准号: 7663386
• 负责人: Nancy L Haigwood
• 金额: $ 52.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7663386
• 关键词: Adenoviruses; Affect; Antigens; Autologous; Cellular Immunity; Codon Nucleotides; Combined Vaccines; Complement component C1; DNA; DNA Vaccines; Data; Development; Effectiveness; Epitopes; Exposure to; Gagging; Generations; Genes; Goals; HIV; HIV vaccine; Immune response; Immunity; Immunization; In Vitro; Individual; Infection; Life; Macaca; Modality; Mutation; Oryctolagus cuniculus; Patients; Plasma; Population; Populations at Risk; Principal Investigator; Protein Subunits; Proteins; Recombinant DNA; Recombinants; Sampling; Serum; Severities; Site; Subunit Vaccines; Testing; Time; Treatment Protocols; Vaccinated; Vaccination; Vaccine Design; Vaccines; Variant; Viral; Viral Genome; Viral Vector; Viremia; Virus; Work; base; cohort; comparative; design; env Gene Products; env Genes; env Glycoproteins; expectation; gene cloning; gp160; immunogenicity; in vivo; neutralizing antibody; novel vaccines; programs; protective efficacy; research study; response; simian human immunodeficiency virus

This project seeks to develop novel vaccines that can be delivered as DNA vaccine components to produce strong neutralizing antibodies. The immunity produced by these vaccines, if successful, can be optimized and then tailored to work in combination with other HIV vaccines to vaccinate at-risk populations and reduce acquisition or severity of HIV.

该项目旨在开发新型疫苗，使其可以作为DNA疫苗的成分来生产