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Vaccination design based on natural env genes to elicit broad neutralizing Abs

Vaccination design based on natural env genes to elicit broad neutralizing Abs
基于天然 env 基因的疫苗设计可引发广泛的中和抗体
批准号：
7663386
负责人：
Nancy L Haigwood
金额：
$52.98万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-07-16 至 2014-06-30
来源：
https://reporter.nih.gov/project-details/7663386
关键词：
AdenovirusesAffectAntigensAutologousCellular ImmunityCodon NucleotidesCombined VaccinesComplement component C1DNADNA VaccinesDataDevelopmentEffectivenessEpitopesExposure toGaggingGenerationsGenesGoalsHIVHIV vaccineImmune responseImmunityImmunizationIn VitroIndividualInfectionLifeMacacaModalityMutationOryctolagus cuniculusPatientsPlasmaPopulationPopulations at RiskPrincipal InvestigatorProtein SubunitsProteinsRecombinant DNARecombinantsSamplingSerumSeveritiesSiteSubunit VaccinesTestingTimeTreatment ProtocolsVaccinatedVaccinationVaccine DesignVaccinesVariantViralViral GenomeViral VectorViremiaVirusWorkbasecohortcomparativedesignenv Gene Productsenv Genesenv Glycoproteinsexpectationgene cloninggp160immunogenicityin vivoneutralizing antibodynovel vaccinesprogramsprotective efficacyresearch studyresponsesimian human immunodeficiency virus

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中文摘要
翻译
该项目旨在开发新型疫苗，使其可以作为DNA疫苗的成分来生产
英文摘要
This project seeks to develop novel vaccines that can be delivered as DNA vaccine components to produce strong neutralizing antibodies. The immunity produced by these vaccines, if successful, can be optimized and then tailored to work in combination with other HIV vaccines to vaccinate at-risk populations and reduce acquisition or severity of HIV.
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