Environmental Contaminants and Reproductive Health of Akwesasne Mohawk Women

阿克维萨斯尼莫霍克族妇女的环境污染物和生殖健康

• 批准号: 7684444
• 负责人: LAWRENCE M SCHELL
• 金额: $ 50.53万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-04 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684444
• 关键词: Age-Years; Back; Blood; Characteristics; Cities; Collection; Communities; Data; Diet; Endocrine disruption; Enrollment; Environmental Pollution; Exposure to; Growth; Lead; Life; Measures; Menstrual cycle; Mohawk Indian; Pituitary Gland; Polychlorinated Biphenyls; Property; Questionnaires; Reproductive Health; Risk; Saliva; Sampling; Structure-Activity Relationship; Techniques; Testing; Universities; Urine; Woman; density; diaries; gonad function; health disparity; innovation; minority health; pollutant; reproductive; superfund site; toxicant

The project led by Drs. Schell and Carpenter, entitled "Environmental contaminants and reproductive health of Akwesasne Mohawk women" builds on a collaborative relationship between the Akwesasne Mohawk Nation and the University at Albany reaching back some 20 years, while also representing an expansion of the Center's focus to the region beyond Albany and Amsterdam. The study's objective is to determine the effect of exposure to PCBs, other persistent organic pollutants and lead on characteristics of the menstrual cycle among Mohawk women who are between 20 and 35 years of age and living in Akwesasne, which is adjacent to a federal and two state Superfund sites. The study will enroll 180 women who will be followed through one menstrual cycle with collection of blood, urine and daily saliva samples to investigate the relationship of PCB congeners and other toxicants to gonadal function, pituitary function and other characteristics of the menstrual cycle measured through diaries and questionnaires. This study has several innovative methodological features: the simultaneous consideration of multiple toxicants with endocrine disrupting properties, the congener specific analysis of PCBs for testing structure-function relationships with regard to reproductive effects, the consideration of these effects within the context of other common influences on reproductive parameters, and the application of statistical techniques and growth curve analyses that take full advantage of the density of data obtained throughout the cycle. The project is equally notable for its meaning and salience to the community. Activities that express and reaffirm Mohawk identity and culture may increase exposure to local contaminants such as PCBs, particularly through diet. The findings of this study will have great significance not only for the promotion of good reproductive health (critical to the survival of the nation as a culture and a people) but also for understanding the risk possibly related to activities that have been traditionally associated with Mohawk ways of life.

由谢尔博士和卡彭特博士领导的题为《环境污染物与生殖健康》的项目 建立在阿克韦萨内·莫霍克人之间合作关系的基础上 国家和奥尔巴尼大学可以追溯到大约20年前，同时也代表着 该中心的重点是奥尔巴尼和阿姆斯特丹以外的地区。这项研究的目的是确定 接触多氯联苯、其他持久性有机污染物和铅对月经特征的影响 在居住在阿克韦萨内的20至35岁的莫霍克妇女中骑自行车，这是 毗邻一个联邦和两个州超级基金网站。这项研究将招募180名女性，并对她们进行跟踪 通过采集一个月经周期的血、尿和日常唾液样本来调查 多氯联苯等毒物与性腺功能、垂体功能等的关系 通过日记和调查问卷测量月经周期的特点。这项研究有几个 创新的方法论特征：同时考虑多种毒物和内分泌 破坏性能，用于测试结构-功能关系的多氯联苯的同类特定分析 关于生殖影响，在其他共同的背景下审议这些影响 对生殖参数的影响以及统计技术和生长曲线的应用 充分利用在整个周期内获得的数据密度的分析。这个项目同样是 值得注意的是它的意义和对社区的重要性。表达和重申莫霍克人身份的活动 培养可能会增加对多氯联苯等当地污染物的暴露，特别是通过饮食。这个 这项研究的结果不仅对促进良好的生殖健康具有重要意义 (对一个国家作为一个文化和一个民族的生存至关重要)，但也是为了理解可能存在的风险 与传统上与莫霍克人的生活方式有关的活动。