Environmental Contaminants and Reproductive Health of Akwesasne Mohawk Women

阿克维萨斯尼莫霍克族妇女的环境污染物和生殖健康

• 批准号: 7684444
• 负责人: LAWRENCE M SCHELL
• 金额: $ 50.53万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT ALBANY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-04 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684444
• 关键词: Age-Years; Back; Blood; Characteristics; Cities; Collection; Communities; Data; Diet; Endocrine disruption; Enrollment; Environmental Pollution; Exposure to; Growth; Lead; Life; Measures; Menstrual cycle; Mohawk Indian; Pituitary Gland; Polychlorinated Biphenyls; Property; Questionnaires; Reproductive Health; Risk; Saliva; Sampling; Structure-Activity Relationship; Techniques; Testing; Universities; Urine; Woman; density; diaries; gonad function; health disparity; innovation; minority health; pollutant; reproductive; superfund site; toxicant

The project led by Drs. Schell and Carpenter, entitled "Environmental contaminants and reproductive health of Akwesasne Mohawk women" builds on a collaborative relationship between the Akwesasne Mohawk Nation and the University at Albany reaching back some 20 years, while also representing an expansion of the Center's focus to the region beyond Albany and Amsterdam. The study's objective is to determine the effect of exposure to PCBs, other persistent organic pollutants and lead on characteristics of the menstrual cycle among Mohawk women who are between 20 and 35 years of age and living in Akwesasne, which is adjacent to a federal and two state Superfund sites. The study will enroll 180 women who will be followed through one menstrual cycle with collection of blood, urine and daily saliva samples to investigate the relationship of PCB congeners and other toxicants to gonadal function, pituitary function and other characteristics of the menstrual cycle measured through diaries and questionnaires. This study has several innovative methodological features: the simultaneous consideration of multiple toxicants with endocrine disrupting properties, the congener specific analysis of PCBs for testing structure-function relationships with regard to reproductive effects, the consideration of these effects within the context of other common influences on reproductive parameters, and the application of statistical techniques and growth curve analyses that take full advantage of the density of data obtained throughout the cycle. The project is equally notable for its meaning and salience to the community. Activities that express and reaffirm Mohawk identity and culture may increase exposure to local contaminants such as PCBs, particularly through diet. The findings of this study will have great significance not only for the promotion of good reproductive health (critical to the survival of the nation as a culture and a people) but also for understanding the risk possibly related to activities that have been traditionally associated with Mohawk ways of life.

该项目由博士领导。谢尔和卡彭特，题为“环境污染物和生殖健康 Akwesasne Mohawk 女性”建立在 Akwesasne Mohawk 之间的合作关系之上 国家和奥尔巴尼大学的历史可以追溯到大约 20 年前，同时也代表了 该中心的重点是奥尔巴尼和阿姆斯特丹以外的地区。该研究的目的是确定 接触多氯联苯、其他持久性有机污染物和铅对月经特征的影响 居住在 Akwesasne 的 20 至 35 岁莫霍克族女性的周期， 毗邻联邦和两个州超级基金所在地。该研究将招募 180 名女性进行跟踪研究 通过一个月经周期收集血液、尿液和每日唾液样本来调查 PCB同系物和其他毒物与性腺功能、垂体功能和其他功能的关系 通过日记和调查问卷测量月经周期的特征。这项研究有几个 创新方法学特点：同时考虑多种毒物与内分泌 PCB 的同类特异性分析，用于测试结构与功能的关系 关于生殖影响，在其他常见问题的背景下考虑这些影响 对生殖参数的影响以及统计技术和生长曲线的应用 充分利用整个周期中获得的数据密度的分析。该项目同样 以其对社区的意义和显着性而闻名。表达和重申莫霍克身份的活动 文化可能会增加对多氯联苯等当地污染物的接触，特别是通过饮食。这 这项研究的结果不仅对于促进良好的生殖健康具有重要意义 （对于国家作为文化和人民的生存至关重要），也有助于了解可能存在的风险 与传统上与莫霍克生活方式相关的活动有关。