Socioemotional Behavior and Amygdala-Based Circuitry in Primates

灵长类动物的社会情感行为和杏仁核回路

• 批准号: 7676883
• 负责人: Ludise Malkova
• 金额: $ 38.38万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-19 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676883
• 关键词: Accounting; Acute; Adolescent; Affective; Aggressive behavior; Agonist; Amygdaloid structure; Animal Model; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Attenuated; Autistic Disorder; Behavior; Behavioral; Bicuculline; Brain; Cell Nucleus; Diagnostic; Diazepam; Disinhibition; Dose; Emotional; Etiology; Evaluation; Fright; GABA Agonists; GABA Antagonists; Grooming; Hand; Human; Impairment; Impulsivity; Individual; Infusion procedures; Lesion; Mediating; Midbrain structure; Monkeys; Muscimol; Network-based; Neurobiology; Non-Rodent Model; Outcome; Output; Pathology; Patients; Pattern; Play; Primates; Process; Psychopathology; Receptor Activation; Regulation; Research; Rewards; Rodent; Role; Sex Characteristics; Site; Social Behavior; Social Interaction; Social Phobia; Specificity; Stimulus; System; Tectum Mesencephali; Testing; Therapeutic; Therapeutic Intervention; Withdrawal; Work; affiliative behavior; base; bicuculline methiodide; depression; emotional reaction; emotional stimulus; interest; neuropsychiatry; nonhuman primate; novel; prevent; receptor; relating to nervous system; response; sex; social; superior colliculus Corpora quadrigemina

DESCRIPTION (provided by applicant): The proposal aims to identify the neural substrates in the brain that are responsible for abnormal socio-emotional behavior. This understanding is vital for developing both diagnostic and therapeutic approaches to identify and treat the abnormal brain circuitry in neuropsychiatric conditions such as affective and anxiety disorders. The field of social behavior research still lacks appropriate animal models for social pathology that leads to inappropriate aggression, social anxiety/phobias, social withdrawal/detachment, impulsivity, or defensiveness. The study of the neurobiology of social behavior in non-rodent models is especially promising since the impairment in social interactions and emotional processing generates symptomatology that resembles psychopathology observed in human patients. Moreover these studies will permit an analysis of social interactions at a level not feasible in rodents. Therefore, this work promises to substantially advance our understanding of the neural substrates of human social interactions in the norm and pathology with a special relevance to anxiety and depression. The proposed research seeks to investigate the novel components of the amygdala-based network that regulates socioemotional responses in order to account for imbalances that can give rise to psychopathology in the absence of structural lesions. The effects of the DLSC manipulations on the vulnerability to behavioral abnormalities evoked by disinhibition within nuclei of the amygdala will be analyzed to determine the role of DLSC in mediating and/or modulating the influence of the amygdala circuitry. An understanding of the functional relationship between the amygdala-derived and colliculus- derived regulation of defensive and aggressive emotional tone is expected to reveal novel targets for both etiology and therapeutic intervention for affective and anxiety disorders.

描述(由申请者提供)：该提案旨在确定大脑中负责异常社会情绪行为的神经底物。这一认识对于开发诊断和治疗方法以识别和治疗情感性和焦虑性障碍等神经精神疾病中的异常脑回路至关重要。社会行为研究领域仍然缺乏适当的动物模型来研究导致不适当攻击、社交焦虑/恐惧症、社交退缩/冷漠、冲动或防御性的社会病理。在非啮齿动物模型中研究社会行为的神经生物学特别有希望，因为社会互动和情绪处理的障碍会产生类似于在人类患者中观察到的精神病理学的症状。此外，这些研究将允许在啮齿动物身上不可行的水平上分析社会互动。因此，这项工作有望极大地促进我们对人类社会互动的神经基础的理解，在与焦虑和抑郁特别相关的规范和病理学中。这项拟议的研究试图调查杏仁核为基础的网络的新组成部分，该网络调节社会情绪反应，以解释在没有结构性损害的情况下可能导致精神病理的失衡。将分析DLSC操作对杏仁核内去抑制引起的行为异常易感性的影响，以确定DLSC在调节和/或调节杏仁核回路影响中的作用。对杏仁核和丘脑来源的防御和攻击性情绪调节之间的功能关系的理解有望揭示情感和焦虑障碍的病因学和治疗干预的新靶点。