MOSAIC: Targeting the Tissue State

MOSAIC:针对组织状态

基本信息

  • 批准号:
    10729422
  • 负责人:
  • 金额:
    $ 34.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-18 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

SUMMARY: PROJECT 1: TARGETING GLIOMA TISSUE STATES Glioblastoma (GBM) displays extensive cellular heterogeneity which represents a major obstacle for effective treatment. This cellular heterogeneity not only consists of multiple tumor cell mutation factors that drive distinct tumor cell behavior, but also impacts various non-tumor cells, contributing to tumor initiation, progression, and treatment response. In fact, GBM’s microenvironment is multifaceted and consists of soluble factors, extracellular matrix components, tissue-resident cells (neuron, astrocytes, endothelial cells, pericytes, etc.) and resident (e.g. microglia) or recruited (e.g. bone-marrow derived macrophages) immune cells. Importantly, changes in the cellular composition and cellular phenotypes can alter GBM tissue states to drive tumor growth and therapeutic resistance. Thus, identifying the unique cellular composition and deciphering the multifaceted bidirectional network between tumor cells and tumor microenvironment signals in various GBM tissue states can lead to identification of novel therapeutic strategies. Our preliminary studies using single nucleus RNAseq of pre- and post-treatment GBM has identified 3 tissue states, corresponding to patterns of cohabitation of tumor and non-tumoral cell subpopulations. These correspond to infiltrated brain, highly cellular proliferating tumor, and astrocytic / inflamed reactive tissue, which is observed in the post-treatment samples and enriched in specific populations of myeloid cells and mesenchymal glioma cells. Co-habitation of specific non-tumor cellular phenotypes in the glioma microenvironment may influence glioma states signatures (astrocyte-like/mesenchymal, progenitor, proliferative) that associate with tumor progression and therapeutic response. The goal of this project is to define the patterns of cellular cohabitation associated with the tissue states and the cross-talk signals that influence local tissue state, phenotypic expression, transitions and disease progression. Because of its known role in cross-talk between specific populations in GBM, we will initially test the effects of targeting TWEAK-Fn14 signaling to drive changes in tissue state. We hypothesize that targeting this as well as other key cross-talk signaling pathways will induce tissue state transitions with corresponding alterations in cellular populations that will render tumors more sensitive to therapeutic vulnerabilities and can be leveraged to slow tumor growth/progression. To investigate the potential impact of such key states and their cross-talk, we propose three aims. Aim 1 focuses on refining our understanding of glioma tissue states in both the pre- and post- treatment setting. Aim 2 investigates cross talk between the glioma cells and their microenvironment and how it may influence progression. Aim 3 looks more locally at how cross-talk perturbations may impact tissue state transition.
项目1:靶向胶质瘤组织状态

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Nhan L Tran其他文献

Uncertainty Quantification in Radiogenomics: EGFR Amplification in Glioblastoma
放射基因组学中的不确定性定量:胶质母细胞瘤中的 EGFR 扩增
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Leland S. Hu;Lujia Wang;A. Hawkins;Jenny M. Eschbacher;K. Singleton;P. Jackson;K. Clark;Christopher P. Sereduk;Sen Peng;Panwen Wang;Junwen Wang;L. Baxter;Kris A. Smith;Gina L. Mazza;Ashley M. Stokes;B. Bendok;Richard S. Zimmerman;C. Krishna;Alyx Porter;M. Mrugala;J. Hoxworth;Teresa Wu;Nhan L Tran;Kristin R Swanson;Jing Li
  • 通讯作者:
    Jing Li
Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells
  • DOI:
    10.1186/s10020-019-0116-z
  • 发表时间:
    2019-11-14
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Harder, Bryan G.;Peng, Sen;Nhan L Tran
  • 通讯作者:
    Nhan L Tran

Nhan L Tran的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Nhan L Tran', 18)}}的其他基金

Chemosensitization of Glioblastoma by Propentofylline
丙茶碱对胶质母细胞瘤的化疗增敏作用
  • 批准号:
    10480470
  • 财政年份:
    2022
  • 资助金额:
    $ 34.34万
  • 项目类别:
TROY HTS Compound Screening
TROY HTS 化合物筛选
  • 批准号:
    9332744
  • 财政年份:
    2016
  • 资助金额:
    $ 34.34万
  • 项目类别:
TROY HTS Compound Screening
TROY HTS 化合物筛选
  • 批准号:
    9222820
  • 财政年份:
    2016
  • 资助金额:
    $ 34.34万
  • 项目类别:
TROY HTS Compound Screening
TROY HTS 化合物筛选
  • 批准号:
    9113331
  • 财政年份:
    2016
  • 资助金额:
    $ 34.34万
  • 项目类别:
TWEAK-Fn14 HTS compound screening
TWEAK-Fn14 HTS 化合物筛选
  • 批准号:
    8874920
  • 财政年份:
    2013
  • 资助金额:
    $ 34.34万
  • 项目类别:
TWEAK-Fn14 HTS compound screening
TWEAK-Fn14 HTS 化合物筛选
  • 批准号:
    8703644
  • 财政年份:
    2013
  • 资助金额:
    $ 34.34万
  • 项目类别:
TWEAK-Fn14 HTS compound screening
TWEAK-Fn14 HTS 化合物筛选
  • 批准号:
    8560590
  • 财政年份:
    2013
  • 资助金额:
    $ 34.34万
  • 项目类别:
Targeting the Fn14-Rac1 signaling pathway in invasive gliomas
靶向侵袭性胶质瘤中的 Fn14-Rac1 信号通路
  • 批准号:
    7874678
  • 财政年份:
    2008
  • 资助金额:
    $ 34.34万
  • 项目类别:
Targeting the Fn14-Rac1 signaling pathway in invasive gliomas
靶向侵袭性胶质瘤中的 Fn14-Rac1 信号通路
  • 批准号:
    8073615
  • 财政年份:
    2008
  • 资助金额:
    $ 34.34万
  • 项目类别:
Targeting the Fn14-Rac1 signaling pathway in invasive gliomas
靶向侵袭性胶质瘤中的 Fn14-Rac1 信号通路
  • 批准号:
    8260789
  • 财政年份:
    2008
  • 资助金额:
    $ 34.34万
  • 项目类别:

相似海外基金

Life outside institutions: histories of mental health aftercare 1900 - 1960
机构外的生活:1900 - 1960 年心理健康善后护理的历史
  • 批准号:
    DP240100640
  • 财政年份:
    2024
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Discovery Projects
Development of a program to promote psychological independence support in the aftercare of children's homes
制定一项计划,促进儿童之家善后护理中的心理独立支持
  • 批准号:
    23K01889
  • 财政年份:
    2023
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Integrating Smoking Cessation in Tattoo Aftercare
将戒烟融入纹身后护理中
  • 批准号:
    10452217
  • 财政年份:
    2022
  • 资助金额:
    $ 34.34万
  • 项目类别:
Integrating Smoking Cessation in Tattoo Aftercare
将戒烟融入纹身后护理中
  • 批准号:
    10670838
  • 财政年份:
    2022
  • 资助金额:
    $ 34.34万
  • 项目类别:
Aftercare for young people: A sociological study of resource opportunities
年轻人的善后护理:资源机会的社会学研究
  • 批准号:
    DP200100492
  • 财政年份:
    2020
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Discovery Projects
Creating a National Aftercare Strategy for Survivors of Pediatric Cancer
为小儿癌症幸存者制定国家善后护理策略
  • 批准号:
    407264
  • 财政年份:
    2019
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Operating Grants
Aftercare of green infrastructure: creating algorithm for resolving human-bird conflicts
绿色基础设施的善后工作:创建解决人鸟冲突的算法
  • 批准号:
    18K18240
  • 财政年份:
    2018
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Development of an aftercare model for children who have experienced invasive procedures
为经历过侵入性手术的儿童开发善后护理模型
  • 批准号:
    17K12379
  • 财政年份:
    2017
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of a Comprehensive Aftercare Program for children's self-reliance support facility
为儿童自力更生支持设施制定综合善后护理计划
  • 批准号:
    17K13937
  • 财政年份:
    2017
  • 资助金额:
    $ 34.34万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Project#2 Extending Treatment Effects Through an Adaptive Aftercare Intervention
项目
  • 批准号:
    8742767
  • 财政年份:
    2014
  • 资助金额:
    $ 34.34万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了