Education and Outreach Core

教育和外展核心

• 批准号: 10729277
• 负责人: Franziska Michor
• 金额: $ 13.2万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729277
• 关键词: Adoption; Algorithms; Automobile Driving; Bioinformatics; Biopsy; Brain Neoplasms; Cells; Clinical; Collaborations; Communication; Communities; Complex; Computational Biology; Computer Models; Coupled; Dana-Farber Cancer Institute; Data; Data Set; Discipline; Disparate; Education; Education and Outreach; Educational Status; Exposure to; Faculty; Faculty Workshop; Female; Fostering; Funding; Funding Opportunities; Future; Genetic; Glioblastoma; Goals; Histology; Human; Immersion; Immunologics; Institution; Internships; Learning; Lesion; Malignant Neoplasms; Modeling; Molecular; Neurons; Oncologist; Participant; Pathologist; Pathway interactions; Phosphoproteins; Pilot Projects; Postdoctoral Fellow; Process; Proteins; Protocols documentation; Publications; Recruitment Activity; Research; Research Personnel; Resolution; Rotation; STEM career; Sampling; Science; Scientist; Series; Site; Slide; Solid; Students; System; Systems Biology; Techniques; Therapeutic; Thinking; Time; Training; Training Programs; Transcript; Tumor stage; Underrepresented Populations; Vision; Visit; Work; analytical method; career; cell type; clinical decision-making; clinical translation; data access; dynamical evolution; empowerment; experience; externship; graduate student; high school; improved; insight; interdisciplinary collaboration; new technology; outreach; post-doctoral training; programs; summer internship; symposium; teacher; tool; training opportunity; treatment response; tumor; tumor microenvironment; tumor progression; undergraduate student; web site

ABSTRACT – EDUCATION AND OUTREACH CORE The scientific goal of our CSBC U54 MIT/DFCI Center for Systems Biology in Glioblastoma is to change the current paradigm in GBM research by bringing new tools and algorithms to improve analysis of the tumor- microenvironment interface, providing ultra-deep systems level molecular characterization at the transcript, protein, phosphoprotein, and metabolite levels while maintaining cell-type specific resolution, with the ultimate aim of developing improved therapeutic strategies for this devastating tumor. Using this theme as a platform, we will engage systems biologists, computational biologists, cancer biologists, and clinicians at all levels of training to cultivate improved cross-disciplinary fluency. Ultimately, these efforts will have an enduring impact on the field by educating future scientists and oncologists and by fostering lasting trans-disciplinary collaborations between established scientists. We will maximize the education and outreach impact of the center through a multi-tiered strategy to promote experiential training and communication across a range of educational and career levels: High school and undergraduate students: We will tap into and expand existing internship and research opportunity programs at several of our sites to engage both teachers and students in the exciting trans- disciplinary studies being performed in the MIT/DFCI CSBC. The central goal for these activities is to enthuse participants about potential STEM careers and provide real-world experiences in different facets of cancer systems biology. Graduate student and post-doctoral training: We will establish a cross-training program that will provide funding for visiting scientists within the MIT/DFCI CSBC or within the larger CSBC network. The vision of this program is to enable cross-disciplinary training, allowing researchers to learn new technologies, be exposed to different ways of thinking about problems, and to gain insight into clinical translation. By providing support for weeks-to-months of interaction time for multiple visiting scientists per year, this program should provide solid experiential training and immersion in the corresponding field. Annual symposia and visiting faculty series: An annual conference hosted by the MIT/DFCI CSBC will rotate among the sites involved in our center. A key goal of these conferences is to establish collaborative interdisciplinary opportunities with our CSBC and within the larger CSBC network. Targeted selection of speakers will maximize the potential for complementary collaborations with the host institution and across the CSBC network. A similar strategy will be employed in developing a rotating visiting faculty seminar series. Web-site and public engagement: To broadcast all of these opportunities and to educate the public with regard to the systems biology of the brain tumor – microenvironment interface, we will establish a center website. This website will also serve as the hub for accessing data, publications, and computational models generated by our CSBC.

摘要-教育和外展核心 我们的CSBC U 54 MIT/DFCI胶质母细胞瘤系统生物学中心的科学目标是改变 通过引入新的工具和算法来改善肿瘤的分析， 微环境接口，提供转录物的超深系统水平分子表征， 蛋白质、磷蛋白和代谢物水平，同时保持细胞类型特异性分辨率， 目的是为这种毁灭性的肿瘤开发更好的治疗策略。利用这个平台，我们 将让系统生物学家、计算生物学家、癌症生物学家和临床医生接受各级培训 培养跨学科的流利性。这些努力最终将对实地产生持久影响 通过教育未来的科学家和肿瘤学家，并通过促进持久的跨学科合作， 既定的科学家。我们将最大限度地提高教育和推广中心的影响，通过多层次的， 在一系列教育和职业水平上促进体验式培训和交流的战略： 高中生和本科生：我们将利用和扩大现有的实习和研究 在我们的几个网站的机会计划，使教师和学生在令人兴奋的跨- 在MIT/DFCI CSBC进行的学科研究。这些活动的中心目标是激发 参与者了解潜在的STEM职业，并提供癌症不同方面的真实经验 系统生物学 研究生和博士后培训：我们将建立一个交叉培训项目， 麻省理工学院/DFCI CSBC或更大的CSBC网络内的访问科学家。这个愿景 该计划旨在实现跨学科培训，让研究人员学习新技术， 以不同的方式思考问题，并深入了解临床翻译。提供支持 对于每年多位访问科学家数周到数月的互动时间，该计划应提供 扎实的经验培训和沉浸在相应的领域。 年度研讨会和访问教师系列：由麻省理工学院/DFCI CSBC主办的年度会议将轮流举行 在我们中心的网站中。这些会议的一个关键目标是建立合作关系， 与我们的CSBC和更大的CSBC网络内的跨学科的机会。有针对性地选择 演讲者将最大限度地发挥与主办机构和跨机构互补合作的潜力， CSBC网络。类似的战略将用于开发一个轮换访问教师研讨会系列。 网站和公众参与：宣传所有这些机会，教育公众 针对脑肿瘤系统生物学-微环境接口，建立中心网站。 该网站还将作为访问数据、出版物和生成的计算模型的中心 我们的CSBC