Education and Outreach Core

摘要--教育和外展核心 我们CSBC U54 MIT/DFCI胶质母细胞瘤系统生物学中心的科学目标是改变 通过引入新的工具和算法来改进对肿瘤的分析，当前GBM研究的范式- 微环境界面，在转录本上提供超深系统级别的分子表征， 蛋白质、磷蛋白和代谢物水平，同时保持细胞类型的特定分辨率，最终 目的是为这种毁灭性的肿瘤开发改进的治疗策略。以这个主题为平台，我们 将邀请系统生物学家、计算生物学家、癌症生物学家和临床医生参加所有级别的培训 培养更好的跨学科流畅性。最终，这些努力将对实地产生持久的影响。 通过培养未来的科学家和肿瘤学家，并促进两国之间持久的跨学科合作 老牌科学家。我们将通过多层次的方式最大限度地发挥中心的教育和外展影响 在一系列教育和职业层面促进体验式培训和沟通的战略： 高中生和本科生：我们将利用和扩大现有的实习和研究 在我们的几个地点提供机会计划，让教师和学生参与到令人兴奋的交流中 麻省理工学院/DFCI CSBC正在进行纪律研究。这些活动的中心目标是激发 参与者了解潜在的STEM职业，并提供癌症不同方面的真实经验 系统生物学。 研究生和博士后培训：我们将建立一个交叉培训计划，提供资金 面向麻省理工学院/DFCI CSBC或更大的CSBC网络中的访问科学家。这是一种愿景 方案是使跨学科培训成为可能，让研究人员学习新技术，暴露 以不同的方式思考问题，并洞察临床翻译。通过提供支持 对于每年几周到几个月的多名访问科学家的互动时间，该计划应该提供 扎实的体验式培训和相应领域的沉浸。 年度研讨会和访问教员系列：由麻省理工学院/DFCI CSBC主办的年度会议将轮流举行 在我们中心涉及的地点中。这些会议的一个关键目标是建立协作 与我们的CSBC以及更大的CSBC网络之间的跨学科机会。有针对性地选择 演讲者将最大限度地发挥与主办机构和 CSBC网络。类似的策略将被用于开发轮流访问教员研讨会系列。 网站和公众参与：广播所有这些机会，并在以下方面教育公众 以脑肿瘤的系统生物学-微环境接口，我们将建立一个中心网站。 该网站还将作为访问数据、出版物和生成的计算模型的中心 由我们的CSBC提供。

ABSTRACT – EDUCATION AND OUTREACH CORE The scientific goal of our CSBC U54 MIT/DFCI Center for Systems Biology in Glioblastoma is to change the current paradigm in GBM research by bringing new tools and algorithms to improve analysis of the tumor- microenvironment interface, providing ultra-deep systems level molecular characterization at the transcript, protein, phosphoprotein, and metabolite levels while maintaining cell-type specific resolution, with the ultimate aim of developing improved therapeutic strategies for this devastating tumor. Using this theme as a platform, we will engage systems biologists, computational biologists, cancer biologists, and clinicians at all levels of training to cultivate improved cross-disciplinary fluency. Ultimately, these efforts will have an enduring impact on the field by educating future scientists and oncologists and by fostering lasting trans-disciplinary collaborations between established scientists. We will maximize the education and outreach impact of the center through a multi-tiered strategy to promote experiential training and communication across a range of educational and career levels: High school and undergraduate students: We will tap into and expand existing internship and research opportunity programs at several of our sites to engage both teachers and students in the exciting trans- disciplinary studies being performed in the MIT/DFCI CSBC. The central goal for these activities is to enthuse participants about potential STEM careers and provide real-world experiences in different facets of cancer systems biology. Graduate student and post-doctoral training: We will establish a cross-training program that will provide funding for visiting scientists within the MIT/DFCI CSBC or within the larger CSBC network. The vision of this program is to enable cross-disciplinary training, allowing researchers to learn new technologies, be exposed to different ways of thinking about problems, and to gain insight into clinical translation. By providing support for weeks-to-months of interaction time for multiple visiting scientists per year, this program should provide solid experiential training and immersion in the corresponding field. Annual symposia and visiting faculty series: An annual conference hosted by the MIT/DFCI CSBC will rotate among the sites involved in our center. A key goal of these conferences is to establish collaborative interdisciplinary opportunities with our CSBC and within the larger CSBC network. Targeted selection of speakers will maximize the potential for complementary collaborations with the host institution and across the CSBC network. A similar strategy will be employed in developing a rotating visiting faculty seminar series. Web-site and public engagement: To broadcast all of these opportunities and to educate the public with regard to the systems biology of the brain tumor – microenvironment interface, we will establish a center website. This website will also serve as the hub for accessing data, publications, and computational models generated by our CSBC.