Multi-site Community Oncology Planning for the CONNECT Intervention Targeting Lung Cancer Caregivers

项目摘要 我们的团队已经证明了社区肿瘤学中基于证据的支持性护理服务的可用性 支持非正式(无偿/家庭)照顾者照顾自己和癌症受照者 治疗(例如，心理社会支持、自我护理/保健课程、医疗任务培训)，但与 这些服务糟糕透顶。迫切需要一个可扩展和系统的流程来确定照顾者的需求 并将照顾者与服务联系起来。这对于肺癌护理人员来说可能特别有价值，他们报告说 特殊的支持性护理需求和高水平的照顾者负担。我们之前展示了强大的实力 护理人员肿瘤学需求评估工具(CONNECT)在试点随机试验中的可行性和可接受性 在一个学术医学中心对40名肺癌护理人员进行的临床试验。我们还观察到了显著的 干预组照顾者负担的改善和抑郁的临床显著减少 与对照组比较。我们建议在下一步的多地点干预规划中，还包括 导航以解决可能阻碍照顾者支持性护理使用的障碍。这项计划的总体目标是 研究的重点是开发创新和可扩展的计划，以改善癌症支持性护理的提供 社区中的照顾者。在此应用程序中，我们建议为未来的多站点收集必要的数据 与维克森林NCI社区肿瘤学研究计划合作的CONNECT疗效试验 研究基地(WF NCORP RB)和主要利益相关者。对于目标1，我们将调查NCORP地点以确定 门诊肿瘤学实践(N=60)对广泛测试CONNECT干预的兴趣和能力 NCORP网络。对于目标2和目标3，我们将进行多点随机试点试验。对于目标2，我们将 评估CONNECT干预登记的多站点可行性(应计、参与和保留 120名肺癌照顾者-患者二人组(CONNECT，n=40；标准护理，n=40；通用资源列表， N=40)，目的是为未来的试验提供方法。对于目标3，我们将获得现场的初步数据 培训需求、参与站点所需的时间以及参与站点之间的沟通流程 并研究人员优化多点介入投放，在今后全面推开试验。待定 为了证明可行性，我们将使用NCORP网络进行未来的全功率疗效试验。

Project Summary Our team has demonstrated availability of evidence-based supportive care services in community oncology to support informal (unpaid/ family) caregivers in caring for themselves and their care recipient undergoing cancer treatment (e.g., psychosocial support, self-care/ wellness classes, medical task training), but connection to these services is abysmal. A scalable and systematic process is critically needed to identify caregiver needs and connect caregivers with services. This may be especially valuable for lung cancer caregivers who report exceptional supportive care needs and high levels of caregiver burden. We previously demonstrated strong feasibility and acceptability of Caregiver Oncology Needs Evaluation Tool (CONNECT) in a pilot randomized clinical trial with 40 lung cancer caregivers at one academic medical center. We also observed significant improvements in caregiver burden and a clinically significant decrease in depression in the intervention group relative to control group. We propose in this next step of multi-site intervention planning, to also include navigation to address barriers that may hamper caregiver supportive care use. The overall goal of this program of research is to develop innovative and scalable programs to improve supportive care delivery for cancer caregivers in the community. In this application, we propose to gather essential data for a future multi-site efficacy trial of CONNECT in collaboration with the Wake Forest NCI Community Oncology Research Program Research Base (WF NCORP RB) and key stakeholders. For Aim 1, we will survey NCORP sites to determine outpatient oncology practice (N=60) interest and capacity to test the CONNECT Intervention across the broad NCORP network. For Aim 2 and Aim 3, we will conduct a multi-site randomized pilot trial. For Aim 2, we will assess the multi-site feasibility (accrual, participation, and retention) of the CONNECT Intervention enrolling 120 lung cancer caregiver-patient dyads (CONNECT, n=40; Standard Care, n=40; Generic Resource List, n=40) with the goal of informing methods for the future trial. For Aim 3, we will obtain preliminary data on site training needs, time needed for site participation, and communication processes between participating sites and study personnel to optimize multi-site intervention delivery in the future fully powered trial. Pending demonstration of feasibility, we will conduct a future fully powered efficacy trial using the NCORP network.