A Multi-Method Investigation of Tonic Immobility and Implications for Trauma-Related Disorders

强直不动及其对创伤相关疾病影响的多方法研究

• 批准号: 10730549
• 负责人: Danielle Marie Morabito
• 金额: $ 3.95万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-05 至 2024-07-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10730549
• 关键词: Adult; Animal Experimentation; Animal Model; Animals; Appointment; Attention; Autobiography; Behavior; Behavior assessment; Behavioral; Cessation of life; Clinical; Consent; Data; Data Reporting; Detection; Diagnosis; Disease; Dissociation; Electroencephalography; Eligibility Determination; Emotions; Event-Related Potentials; Female; Freezing; Fright; Future; Goals; Health; Heart Rate; Hour; Human; Image; Immobilization; Individual; Individual Differences; Injury; Interview; Investigation; Knowledge; Laboratories; Link; Literature; Maintenance; Measures; Mental Health; Methodology; Methods; Military Personnel; Modeling; National Institute of Mental Health; Nature; Participant; Patient Self-Report; Pattern; Physiological; Populations at Risk; Post-Traumatic Stress Disorders; Posture; Psychopathology; Public Health; Questionnaires; Reaction; Reporting; Research; Research Domain Criteria; Research Personnel; Reverse engineering; Risk; Statistical Methods; Stimulus; Structure; Survivors; Symptoms; Tonic Immobility Response; Training; Trauma; Work; active duty; behavior measurement; clinical diagnosis; combat; experience; experimental study; fighting; first responder; graduate student; indexing; insight; neural; neurophysiology; physical conditioning; preventive intervention; response; sexual assault; skills; trauma exposure; traumatic event

Project Summary. Extant research on animal and human threat responding has identified adaptive ways of managing threat (i.e. fight-flight-freeze). Although freezing in response to threat may be adaptive in certain circumstances, it can also reduce chances of escape, resulting in increased physical and mental health risk. Despite its importance, research on human freeze responding is highly limited due to lack of integration across levels of analysis. While the majority of studies use retrospective self-report measures of tonic immobility (TI) that were reverse engineered from anecdotal reports of freezing in response to traumatic events such as sexual assault and combat, experimental studies of freeze response in humans evolved from animal research paradigms. Thus, examination of human immobility in response to threat currently relies on retrospective self- report or behavioral data alone, making it difficult to integrate and compare findings across studies. Additionally, though animal research suggests a link between freezing and alterations in threat processing, research has not yet begun to examine the neural basis of human immobility in response to threat. The P1 and LPP event-related potentials (ERPs), which have been reliably associated with attention to threat and threat processing, may provide insight into the nature and impact of freeze responses including TI. Taken together, the overall aim of the current proposal is to examine immobility in response to threat and its relationship with trauma related psychopathology across multiple levels of analysis, consistent with the NIMH RDoC initiative. The proposed study will 1) develop a unified index of TI utilizing a lab-based experimental threat paradigm to assess behavioral and self-report markers of immobility, 2) investigate the neural markers associated with immobility in response to threat (i.e. P1, LPP), and 3) examine the associations between prior TI exposure, lab- induced immobility, and psychopathology across individuals and groups. Adult female participants (N = 180) including individuals with prior TI, prior trauma exposure without TI, and healthy controls will complete one three-hour lab appointment after determination of initial eligibility and consent. Trained doctoral level graduate students will administer structured clinical interviews (SCID-5-RV) to determine eligibility and diagnoses. Then, participants will complete a self-report questionnaire battery followed by two experimental tasks. Previously validated image viewing and autobiographical script tasks will be used to elicit immobility responses. Behavioral (postural sway, heart rate), neurophysiological (EEG/ERP), and self-report data will be collected. The proposed study will serve to inform future research, preventative interventions, and treatment of trauma- related disorders. Another key aspect of this proposal will be in the training that the primary investigator (PI) receives. This training will provide the PI with the necessary skills to integrate neurophysiological and advanced statistical methods into future work.

项目摘要。对动物和人类威胁反应的现有研究已经确定了适应性的方法， 威胁管理（Fight-Flight-Freeze）虽然在某些情况下，对威胁做出的冻结反应可能是适应性的， 在这种情况下，它还可以减少逃跑的机会，从而增加身心健康风险。 尽管其重要性，但由于缺乏跨学科的整合，对人体冷冻反应的研究非常有限。 分析水平。虽然大多数研究使用强直性不动（TI）的回顾性自我报告措施， 这些都是从轶事报道中反向工程出来的， 性侵犯和战斗，人类冻结反应的实验研究从动物研究演变而来 范例因此，对人类在应对威胁时的不动性的检查目前依赖于回顾性的自我评估。 报告或行为数据，使得难以整合和比较研究结果。 此外，尽管动物研究表明，冻结和威胁处理的改变之间存在联系， 研究尚未开始检查人类对威胁作出反应而不动的神经基础。P1和 LPP事件相关电位（ERPs），已被可靠地与威胁和威胁的注意力相关 处理，可以提供对包括TI的冻结响应的性质和影响的洞察。综合起来看， 当前提案的总体目标是研究对威胁的不动性及其与 创伤相关的精神病理学在多个层次的分析，符合NIMH RDoC倡议。 拟议的研究将：1）利用基于实验室的实验威胁范例开发一个统一的TI指数， 评估不动的行为和自我报告标志物，2）调查与 对威胁的不动性（即P1，LPP），以及3）检查先前TI暴露，实验室- 导致的不动性，以及个体和群体的精神病理学。成年女性受试者（N = 180） 包括先前有TI的个体、先前没有TI的创伤暴露个体和健康对照者将完成一项 在确定初始合格性和知情同意后进行三小时实验室预约。培养的博士毕业生 学生将管理结构化临床面试（SCID-5-RV），以确定资格和诊断。然后， 参与者将完成一组自我报告问卷，然后完成两项实验任务。先前 将使用经验证的图像观看和自传体脚本任务来引起不动反应。 将收集行为（姿势摇摆、心率）、神经生理（EEG/ERP）和自我报告数据。 拟议的研究将为未来的研究、预防性干预和创伤治疗提供信息- 相关疾病。该提案的另一个关键方面是培训主要研究者（PI） 接收。该培训将为PI提供必要的技能，以整合神经生理学和 将先进的统计方法应用到今后的工作中。