Proprioceptive Sensorimotor Integration with Neural Interfaces for Hand Prostheses
本体感觉感觉运动与手假肢神经接口的集成
基本信息
- 批准号:10728873
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-11-01 至 2025-10-31
- 项目状态:未结题
- 来源:
- 关键词:AgonistAmputationAmputeesAnesthesia proceduresArticulationChronicContralateralDevelopmentDevicesElectrodesElectromyographyEsthesiaFeedbackForearmFreedomFrequenciesFundingGoalsGrowthHandHealth Care CostsImplantImplanted ElectrodesIndividualInjectionsIntramuscularIntuitionKnowledgeLaboratoriesLidocaineLimb ProsthesisLimb structureMotionMotorMovementMuscleMusculoskeletal EquilibriumMyoelectric prosthesisNerveNerve BlockNeuromuscular DiseasesNeurosciencesOperative Surgical ProceduresOutputOwnershipParticipantPatternPerceptionPerformancePeripheral Nerve StimulationPhantom Limb PainPhysiologic pulsePlayPopulationPositioning AttributePostureProcessProprioceptionProsthesisPsychometricsQuality of lifeRadialRegression AnalysisResearchResidual stateRoleSchemeSensorySignal TransductionSpinal cord injuryStimulusStrokeStructure of radial nerveStructure of ulnar nerveSurveysSystemTechnologyTestingTimeTouch sensationUpper ExtremityUpper armVeteransWorkantagonistarmcopingexperimental studyfinger movementgraspimprovedkinematicslimb lossmedian nervemotor controlmuscle reinnervationneuralneural implantneural stimulationneurological rehabilitationneurophysiologyprosthesis controlprosthesis wearerprosthetic handpsychosocialrecruitrehabilitation strategyreinnervationsensorimotor systemsensory inputsomatosensorystandard of carevirtualvirtual realityvisual feedback
项目摘要
Current prosthetic options do not meet the needs of all Veterans with upper extremity limb loss. Chronically-
implanted neural interfaces have shown promise for providing intuitive control and somatosensory feedback to
prosthesis users. However, restoring proprioception, which is the sense of limb position and movement, via
neural stimulation remains largely unexplored. Proprioception is critical for informing and modulating motor
control in able-bodied individuals, and without it, prosthesis users must rely on visual feedback. The goal of this
study is to understand the perception of proprioception from peripheral nerve stimulation (PNS) and its
integration with prosthesis control. The central hypothesis is that sensorimotor integration will be best when
both the proprioceptive inputs and the prosthesis control scheme match the underlying neural representations
of sensorimotor processes in the extant body schema. Providing natural proprioception to Veterans with upper
limb loss is the next critical step in the advancement of upper limb prosthetics toward having a hand again.
Six participants with unilateral trans-radial or trans-humeral limb loss will be implanted with chronic neural
and muscular interfaces. Composite Flat Interface Nerve Electrodes (C-FINEs) will be implanted around the
residual median, ulnar, and radial nerves in the upper arm. Three trans-radial participants will be implanted
with bipolar intramuscular electromyography (EMG) electrodes (IMs) in residual muscles in the forearm. Three
trans-humeral amputees will receive Targeted Muscle Reinnervation (TMR) surgery at the time of implant and
IMs will be placed in re-innervated muscles. Participants will attend laboratory testing sessions every 45 days
for two years to complete experiments for the three specific aims of the study.
In Aim 1, proprioceptive percepts elicited by peripheral nerve stimulation will be characterized. PNS-elicited
perceived hand movements will be tracked through contralateral posture matching. Regression analyses will be
performed to determine the contribution of various stimulation parameters on the resulting perceived hand
kinematics. This information will be used to build a stimulation encoder to provide time-varying proprioceptive
information. Paired agonist-antagonist PNS strategies will also be developed. The discriminability of agonist-
only and paired agonist-antagonist strategies will be compared with psychometric tests.
In Aim 2, the role of direct muscle activation from PNS on stimulation-elicited proprioceptive percepts will
be examined. A nerve block using lidocaine injection will be performed on trans-radial participants to
temporarily anesthetize the forearm muscles. Perceived movements and EMG activity will be compared before
and after motor block for various PNS stimuli. For trans-humeral participants who will receive TMR, muscle re-
innervation takes ~3 months. Proprioceptive percepts and EMG activity will be compared before and after re-
innervation is complete. All participants will perform psychometric experiments assessing PNS stimuli, and
discriminability will be compared for pulse frequencies above and below tetanic contraction frequency.
In Aim 3, the integration of artificial proprioception with motor control will be assessed. In a virtual posture
matching task, participants will control a virtual hand to achieve target postures using EMG signals recorded
from the IMs. Two control paradigms will be compared: 1) position-based control, which aims to mimic natural
hand posture control in able-bodied individuals, and 2) velocity-based control, which is typical for
commercially-available prostheses. Performance will be compared with and without stimulation-evoked
proprioceptive feedback. In a psychometric dissimilarity rating task, participants will rate the subjective
dissimilarity of pairs of stimulation-evoked percepts. Some pairs will also contain voluntary hand motions along
with the stimulation. Ratings will be compared between passive and active proprioceptive conditions to
determine the effect of voluntary control on stimulation-evoked percepts. Surveys to assess embodiment and
agency will also be compared before and after each research session.
目前的假肢选择不能满足所有上肢丧失的退伍军人的需要。长期,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Emily L Graczyk其他文献
Emily L Graczyk的其他文献
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{{ truncateString('Emily L Graczyk', 18)}}的其他基金
Proprioceptive Sensorimotor Integration with Neural Interfaces for Hand Prostheses
本体感觉感觉运动与手假肢神经接口的集成
- 批准号:
10517285 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Proprioceptive Sensorimotor Integration with Neural Interfaces for Hand Prostheses
本体感觉感觉运动与手假肢神经接口的集成
- 批准号:
10317327 - 财政年份:2021
- 资助金额:
-- - 项目类别:
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