Behavioral and physiological linkage in people with frontotemporal dementia and spousal caregivers

额颞叶痴呆患者和配偶照顾者的行为和生理联系

• 批准号: 10730125
• 负责人: Kuan-Hua Chen
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-15 至 2022-12-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10730125
• 关键词: Behavioral; physiological; linkage; people; frontotemporal

PROJECT SUMMARY This Pathway to Independence Award will equip the candidate with the key skills to study interpersonal connectedness by examining behavioral and physiological linkage (e.g., how closely people’s heart rates and emotional behaviors are synchronized) in individuals with frontotemporal dementia (FTD) and their spousal caregivers (CGs). FTD is associated with profound neurodegeneration in the frontal and temporal regions of the brain and severe socioemotional symptoms (e.g., apathy, disinhibition) that are difficult not only for the person with dementia (PWD) but also for the CG. Caring for a loved one with FTD can be a meaningful part of family life; however, disruptive symptoms can produce deleterious effects and undermine CGs’ health and well-being. Given the strong associations established between close interpersonal connectedness and health/well-being, the candidate plans to take novel steps to examine (a) how interpersonal connectedness of the PWD and CG is altered in FTD (Aims 1 and 3), and (b) how altered PWD-CG connectedness provides a bridge that links PWD’s socioemotional symptoms to CG’s health declines (Aim 2). Importantly, the candidate plans to study PWD-CG connectedness by assessing both behavioral and physiological indicators of PWD-CG connectedness. This novel approach will provide more objective, less cognitive-demanding, and more continuous measures for PWD-CG connectedness, as compared to single self-report measures that have typically been used in past research. The candidate also plans to develop the optimal methodological approach for quantifying PWD-CG connectedness in both laboratory and naturalistic settings (e.g., identify the measure of physiological linkage that best predicts poor CG health; Aim 4). The candidate has received solid training in cognitive neuroscience and has a strong track record using integrative methods to study emotion and social functioning in healthy and clinical populations. To support the candidate in conducting the proposed research, training in 3 areas is planned: (a) dyadic behavioral and physiological time series data analysis, (b) diagnosis and clinical assessment of FTD, and (c) dementia caregiving. Training will occur under the mentorship of renowned experts in each field (including a clinical psychologist, a behavioral neurologist, and a nurse specialist). The training environment at the Department of Psychology, University of California, Berkeley (primary), and the Memory and Aging Center, University of California, San Francisco (secondary), will be ideal for the proposed training and research, as well as for developing the candidate’s professional skills. Together, the award will help the candidate launch his research career as an independent scientist with unique expertise in dyadic emotion and psychophysiology, neurodegenerative disease, and caregiving. The proposed research will help advance the understanding of the pathways through which FTD yields collateral damage on CGs, and provide a novel, objective, continuous, and potentially portable measure to quantify PWD-CG connectedness for future research and clinical use.

项目摘要 这个独立之路奖将装备候选人的关键技能，研究人际关系 通过检查行为和生理联系的连通性（例如，人们的心率和 情绪行为是同步的）在额颞叶痴呆（FTD）患者及其配偶中 护理人员（CG）。FTD与额叶和颞叶区域的深度神经变性相关， 大脑和严重的社会情绪症状（例如，冷漠，抑制解除），这不仅对人来说是困难的， 老年痴呆症（PWD），也适用于CG。照顾患有FTD的亲人可能是家庭中有意义的一部分 然而，破坏性症状可能产生有害影响，并破坏CG的健康和福祉。 鉴于密切的人际关系与健康/福祉之间存在着密切的联系， 候选人计划采取新的步骤来研究（a）PWD和CG的人际联系如何 FTD的改变（目的1和3），以及（B）改变的PWD-CG连接性如何提供连接 PWD的社会情绪症状对CG的健康下降（目的2）。重要的是，候选人计划学习 通过评估PWD-CG的行为和生理指标来评估PWD-CG连接性 连通性这种新颖的方法将提供更客观，更少的认知要求， 连续测量PWD-CG连通性，与单一自我报告测量相比， 通常用于过去的研究。候选人还计划开发最佳方法论方法 用于在实验室和自然环境中量化PWD-CG连接性（例如，确定...的尺度 最好地预测差CG健康的生理联系;目的4）。候选人接受了扎实的培训， 认知神经科学，并有很强的记录使用综合方法来研究情绪和社会 在健康和临床人群中发挥作用。为了支持候选人进行拟议的研究， 计划在3个领域进行培训：（a）二元行为和生理时间序列数据分析，（B）诊断 和FTD的临床评估，和（c）痴呆。培训将在以下人员的指导下进行： 每个领域的知名专家（包括临床心理学家，行为神经学家和护士 专家）。加州大学伯克利分校心理学系的培训环境 （小学）和记忆和衰老中心，加州大学，旧金山弗朗西斯科（中学），将是理想的 用于拟议的培训和研究，以及发展候选人的专业技能。在一起， 该奖项将帮助候选人作为具有独特专业知识的独立科学家开始他的研究生涯 在情感和心理生理学、神经退行性疾病和抑郁症方面。拟议研究 有助于加深对FTD对CG产生附带损害的途径的理解， 提供了一种新的、客观的、连续的和潜在的便携式测量来量化PWD-CG连接性 用于未来的研究和临床应用。