Behavioral Sleep Medicine: Training in Sleep and Aging

摘要 目标：Perlis博士请求K24支持：1)保持和扩大他对初级调查人员的指导 行为睡眠医学(BSM)领域和研究失眠的生物心理社会方法；以及2) 扩大他关于睡眠和衰老的研究计划。背景：佩利斯博士一直致力于以病人为本 从他30岁左右的S开始研究。他一直是非凡导师的受益者，并将这一点发扬光大 贯穿他整个职业生涯的传统。他的研究虽然关注范围狭窄，但从基础研究扩展到以患者为中心 到流行病学研究。他的工作包括175篇同行评议的文章，38章和三本书。其中四个 章节在本领域的旗舰教科书《睡眠医学的原理和实践》中。这项工作已经完成 极具影响力(H指数为68，被引用超过19,000次)，为他赢得了SBSM的彼得·豪里终身监禁 成就奖，SRS的Mary Carskadon教育奖提名，以及SBSM的 BSM“奖。环境：宾夕法尼亚大学是美国首屈一指的睡眠和睡眠中心之一 时间生物学研究和睡眠医学/行为睡眠医学临床服务。因此，它有很多 为私家侦探和他的实习生提供。发展活动：导师专业人士的核心活动 开发将实施第二代月度研讨会系列，重点是睡眠和 衰老。这一系列节目将与迈克尔·格兰德博士共同主持，作为亚利桑那大学基本 行为睡眠医学系列讲座的主题。将邀请顶尖科学家与他们讨论他们的想法 关于衰老对睡眠的影响。这些讲座将以视频会议的形式提供(不向所有人开放 成本)，并将被存档，以便在可预见的将来可以访问它们。在K24时间范围内， 佩利斯博士还将完成开放式睡眠健康筛查和睡眠跟踪应用程序的开发。 这两个系统都将被设置为从数千个人那里捕获数据。两者都将作为数据档案。研究： 候选人创建了一个协作网络，与JR一起进行档案分析。调查人员使用他的NIA 支持：1)失眠数据库的自然历史和2)部分加强失眠的医疗治疗 数据库(n=3)。此外，他的实习生和合作者将可以访问他的计划的招聘 数据库(n=5000+)，HIS精神病学ISI筛查数据库(n=3,000)，风险效益网络荟萃分析 数据库(PI：J.Cheung)，他新建立的筛选器和跟踪器数据库，以及三个行业数据库 (其中两个将用于描述阿尔茨海默氏症和帕金森氏症患者的睡眠情况；其中一个将 用于描述失眠患者的急性和慢性安慰剂反应，重点是年龄对 安慰剂反应)。被邀请分析12个数据库中的一个或多个的个人将具有专业知识 因此，这将成为国际和平协会教与学的机会。一次会议 将在该奖项的第五年为所有合作者和实习生举办。意义：这款K24将支持Dr。 Perlis努力促进和指导以患者为导向的研究，重点是衰老对睡眠连续性的影响。

ABSTRACT Goals: Dr. Perlis requests K24 support to: 1) maintain and expand his mentoring of junior investigators in the area of behavioral sleep medicine (BSM) and in the biopsychosocial approach to the study of insomnia; and 2) expand his program of research on sleep and aging. Background: Dr. Perlis has been involved in patient-oriented research since his late-20’s. He has been the beneficiary of exceptional mentorship and has carried forward this tradition over the entirety of his career. His research, while narrow in focus, extends from basic to patient-oriented to epidemiologic studies. His work includes 175 peer reviewed articles, 38 chapters, and three books. Four of the chapters are in our field’s flagship text book, the Principles and Practice of Sleep Medicine. The work has been highly impactful (H-Index of 68 with over 19,000 citations) and has earned him the SBSM’s Peter Hauri Lifetime Achievement award, nominations for the SRS’s Mary Carskadon Education Award, and the SBSM’s “Champion of BSM” Award. Environment: The University of Pennsylvania is one of the nation’s premier centers for sleep and chronobiology research and sleep medicine / behavioral sleep medicine clinical services. As such, it has much to offer both the PI and his trainees. Development Activities: The core activity for the mentor’s professional development will be the implementation of a 2nd generation of monthly seminar series focused on Sleep and Aging. This series will be co-hosted with Dr. Michael Grander as part of the University of Arizona’s Essential Topics in Behavioral Sleep Medicine Lecture Series. Leading scientists will be invited to discuss their ideas with respect to the effects of aging on sleep. These lectures will be offered as video conferences (open to all at no cost) and will be archived so that they may be accessed into the foreseeable future. During the K24 time frame, Dr. Perlis will also complete the development of an open access sleep health screener and a sleep tracker app. Both will be setup to capture data from thousands of individuals. Both will serve as data archives. Research: The candidate has created a collaborative network to conduct archival analysis with Jr. Investigators using his NIA supported: 1) natural history of insomnia databases and 2) partial reinforcement of medical treatment of insomnia databases (n=3). Additionally, his trainees and collaborators will have access to his programs’ recruitment database (n=5000+), his ISI in psychiatry screening database (n=3,000), a risk benefit network meta-analysis database (PI: J. Cheung), his newly established screener and tracker databases, and three industry databases (two of which will be used to profile sleep in patients with Alzheimer’s and Parkinson’s disease; one of which will be used to profile acute and chronic placebo response in patients with insomnia, with a focus on age effects on placebo responding). The individuals invited to analyze one or more of the 12 databases will have specialty areas apart from the PI, and thus will serve as an opportunity for the PI to both teach and learn. A conference will be held in the 5th year of this award for all collaborators and trainees. Significance: This K24 will support Dr. Perlis’ efforts to promote and mentor patient-oriented research, with a focus on aging effects on sleep continuity.