Pilot/Exploratory Studies Core

初步/探索性研究核心（PESC）：项目总结 试点/探索性研究核心（PESC）的总体目标是培养和支持尖端试点 和探索性研究，将促进有效预防和/或治疗虚弱的发展 从而促进老年人的独立性。PESC核心领导人与其他领导人密切合作， 核心领导人，并与OAIC的科学愿景一致，为下一阶段设定科学目标， 试点脆弱性研究。然后，他们努力确定调查人员的专业知识和职业目标将是 适用于在目标地区进一步提高病因学和干预知识。试验性和探索性 可以收集所需数据的研究，以便选择或设计未来的大规模或验证性研究 需要建立脆弱机制，改善测量和诊断，确定病因，或开发 优先考虑新的治疗方法。本周期第一年选定供资的研究包括： 一项研究，使用基于视频的姿势估计来开发一个自动化的，定量的脆弱性和预脆弱性 评估老年人，一种多模式方法，以发现遗传签名的脆弱性，在TOPMed 人口研究，以及为年老、体弱和服务不足的患者提供数字访问的试点研究 等待肾脏移植，以促进改善这一最脆弱群体的医疗保健。的具体目标 PESC将：1）征集、选择和支持试点研究，以促进脆弱性的科学和翻译 研究，2）支持设计良好和信息丰富的试点研究的发展，3）提供和 对所支持的调查人员进行纵向指导，并通过完成 试点奖励和追求资金的下一阶段的研究，4）进一步指导翻译的任何 试点研究结果，以及5）扩大研究环境和网络的弱点为重点的调查 实现OAIC的总体目标。这些目标将在与下列机构密切合作下实现： 生物统计学、生物学机制以及临床翻译和招聘核心领导人，以确保最佳 设计和获得研究成功所需的核心资源。新技术评估和解决方案 核心（RC 4）将带来新的和独特的工程重点研究到这个核心。这一核心也将指导 将试点工作转化为对脆弱性的基本生物学和人口影响的更深入理解 以及预防或治疗虚弱从而帮助保持独立的干预措施。

Pilot / Exploratory Studies Core (PESC): Project Summary The overall goal of the Pilot / Exploratory Studies Core (PESC) is to cultivate and support cutting edge pilot and exploratory studies that will advance the development of effective prevention and/or therapies for frailty and hence facilitate independence in older adults. The PESC Core leaders, in close collaboration with other core leaders and congruent with the scientific vision of the OAIC, sets scientific goals for the next stages of pilot frailty research. They then work to identify investigators whose expertise and career goals would be applicable to furthering etiological and interventional knowledge in the targeted areas. Pilot and exploratory studies that can collect data required in order to select or design the future large-scale or confirmatory studies needed to establish frailty mechanisms, improve measurement and diagnosis, determine etiologies, or develop novel treatment approaches are prioritized. Studies selected for funding in the first year of this cycle include a study that uses video-based pose estimation to develop an automated, quantitative frailty and pre-frailty assessment in older adults, a multimodal approach to finding genetic signatures of frailty in TOPMed population studies, and a pilot study of provision of digital access to older, frail and underserved patients awaiting kidney transplant to facilitate improved health care in this most vulnerable group. The specific aims of the PESC are to 1) solicit, select, and support pilot studies that advance the science and translation of frailty research, 2) to support the development of well-designed and informative pilot studies, 3) to provide and conduct longitudinal mentorship to supported investigators as well as provide oversight through completion of the pilot award and pursuit of funding for the next stage of research, 4) to further guide the translation of any pilot study results, and 5) to expand the research environment and network of frailty-focused investigators needed to accomplish the overall OAIC goals. These aims will be carried out in close collaboration with biostatistics, biological mechanisms, and clinical translational and recruitment core leaders to ensure optimal design and access to core resources needed for study success. A new Technology Assessment and Solutions Core (RC4) will bring new and unique engineering focused studies into this core. This core will also guide the translation of pilot work into a deeper understanding of the basic biology and population implications of frailty and into interventions that will prevent or treat frailty hence help maintain independence.