FASEB Summer Research Conference on Osteopontin Biology

描述(申请人提供)：骨桥蛋白是多功能蛋白家族中研究最广泛的成员，该家族被称为小整合素结合配体N-连接糖蛋白(兄弟姐妹)。该家族的其他成员包括骨涎蛋白、牙本质基质蛋白-1、牙本质涎磷蛋白和基质细胞外磷酸蛋白。顾名思义，这些蛋白质最初被认为仅限于在骨骼组织中表达，尽管它们也在滋养细胞、某些免疫细胞和活性分泌细胞中表达。骨桥蛋白(和兄弟姐妹)生物学是前哨领域的高度研究兴趣，包括天然和获得性免疫、细胞凋亡、炎症、应激反应、恶性疾病、新生血管和伤口愈合。兄弟姐妹是本质上非结构化的蛋白质，具有与多种受体(CD44变种和整合素)、细胞外基质成分和蛋白酶结合的能力。由于广泛的分子相互作用以及骨桥蛋白似乎在其中发挥重要作用的科学学科，来自不同背景的研究人员将受益于分享研究设计、方法学和实验结果方面的进展。会议的目标是：召集一个国际小组，成员包括OPN生物学方面的知名专家以及初级科学家。通过多学科的介绍，确定OPN在正常生理功能和疾病病理方面的最新知识。促进多个领域(生物化学、细胞生物学、分子生物学、肿瘤学、免疫学、血管和骨生物学)的交叉受精，以及初级科学家接触跨学科和翻译研究。在OPN的发展中激发翻译合作，作为病理状态的标记和干预的治疗目标。 公共卫生相关性：骨桥蛋白是一种多任务蛋白质，其在正常发育和人类疾病进展中的作用已在许多不同的科学领域进行了研究。这次会议将汇集来自不同学科的科学家，讨论骨桥蛋白和相关蛋白质在正常生理中的作用以及它们作为多发性硬化症、类风湿性关节炎和癌症等疾病的治疗靶点的当前知识。

DESCRIPTION (provided by applicant): Osteopontin is the most widely studied member of a family of multifunctional proteins that have been termed Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs). Other members of the family include bone sialoprotein, dentin matrix protein-1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. As their individual names imply, these proteins were initially considered to be restricted in expression to skeletal tissue, though they are also expressed in trophoblasts, certain immune cells, and active secretory cells. Underlying osteopontin (and SIBLING) biology are sentinel areas of high research interest, including innate and adaptive immunity, apoptosis, inflammation, stress response, malignant disease, neovascularization and wound healing. SIBLINGs are intrinsically unstructured proteins that have the capacity to bind to multiple receptors (CD44 variants and integrins), extracellular matrix components, and proteases. Because of the broad range of molecular interactions as well as scientific disciplines where osteopontin appears to play an important role, researchers from diverse backgrounds will benefit by sharing advances in study design, methodology and experimental results. The goals of the Conference are to: Convene an international group that includes established experts on OPN biology as well as junior scientists. Through multidisciplinary presentations determine the state-of-the-art knowledge on OPN in normal physiological function and disease pathology. Facilitate cross-fertilization of multiple fields (biochemistry, cell biology, molecular biology, oncology, immunology, vascular and bone biology) as well as junior scientist exposure to interdisciplinary and translational research. Spark translational collaborations in the development of OPN as a marker for pathological states and as a therapeutic target for intervention. PUBLIC HEALTH RELEVANCE: Osteopontin is a multitasking protein whose roles in normal development as well as in human disease progression are studied in a number of different scientific fields. This meeting will bring together scientists from across a wide spectrum of disciplines to discuss the current knowledge of the roles of osteopontin and related proteins in normal physiology as well as their potential as therapeutic targets in diseases such as multiple sclerosis, rheumatoid arthritis and cancer.