FASEB Summer Research Conference on Osteopontin Biology

FASEB 骨桥蛋白生物学夏季研究会议

• 批准号: 8004256
• 负责人: NEAL S FEDARKO
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8004256
• 关键词: Apoptosis; Area; Arts; Binding; Biochemistry; Biology; Blood Vessels; CD44 gene; Cells; Cellular biology; Collaborations; DSPP gene; Development; Discipline; Disease; Disease Progression; Exposure to; Extracellular Matrix; Family; Family member; Fertilization; Glycoproteins; Goals; Immune; Immunology; Individual; Inflammation; Integrin Binding; Integrins; International; Intervention; Knowledge; Ligands; Link; Malignant - descriptor; Malignant Neoplasms; Methodology; Molecular Biology; Multiple Sclerosis; Names; Pathology; Peptide Hydrolases; Physiological; Physiology; Play; Proteins; Research; Research Design; Research Personnel; Rheumatoid Arthritis; Role; Scientist; Secretory Cell; Sentinel; Siblings; Translational Research; Variant; Wound Healing; adaptive immunity; benefit sharing; biological adaptation to stress; bone; bone sialoprotein; dentin matrix protein 1; human disease; interest; meetings; member; multidisciplinary; multitask; neovascularization; oncology; osteopontin; public health relevance; receptor; skeletal tissue; symposium; therapeutic target; trophoblast

DESCRIPTION (provided by applicant): Osteopontin is the most widely studied member of a family of multifunctional proteins that have been termed Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs). Other members of the family include bone sialoprotein, dentin matrix protein-1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. As their individual names imply, these proteins were initially considered to be restricted in expression to skeletal tissue, though they are also expressed in trophoblasts, certain immune cells, and active secretory cells. Underlying osteopontin (and SIBLING) biology are sentinel areas of high research interest, including innate and adaptive immunity, apoptosis, inflammation, stress response, malignant disease, neovascularization and wound healing. SIBLINGs are intrinsically unstructured proteins that have the capacity to bind to multiple receptors (CD44 variants and integrins), extracellular matrix components, and proteases. Because of the broad range of molecular interactions as well as scientific disciplines where osteopontin appears to play an important role, researchers from diverse backgrounds will benefit by sharing advances in study design, methodology and experimental results. The goals of the Conference are to: Convene an international group that includes established experts on OPN biology as well as junior scientists. Through multidisciplinary presentations determine the state-of-the-art knowledge on OPN in normal physiological function and disease pathology. Facilitate cross-fertilization of multiple fields (biochemistry, cell biology, molecular biology, oncology, immunology, vascular and bone biology) as well as junior scientist exposure to interdisciplinary and translational research. Spark translational collaborations in the development of OPN as a marker for pathological states and as a therapeutic target for intervention. PUBLIC HEALTH RELEVANCE: Osteopontin is a multitasking protein whose roles in normal development as well as in human disease progression are studied in a number of different scientific fields. This meeting will bring together scientists from across a wide spectrum of disciplines to discuss the current knowledge of the roles of osteopontin and related proteins in normal physiology as well as their potential as therapeutic targets in diseases such as multiple sclerosis, rheumatoid arthritis and cancer.

描述（由申请人提供）：骨桥蛋白是多功能蛋白家族中研究最广泛的成员，被称为小整合素结合配体和N-连接糖蛋白（SIBLING）。该家族的其他成员包括骨唾液酸蛋白、牙本质基质蛋白-1、牙本质唾液酸磷蛋白和基质细胞外磷酸糖蛋白。正如它们各自的名字所暗示的，这些蛋白最初被认为仅限于骨骼组织表达，尽管它们也在滋养层、某些免疫细胞和活性分泌细胞中表达。骨桥蛋白（和SIBLING）生物学是高度研究兴趣的前哨领域，包括先天性和适应性免疫、细胞凋亡、炎症、应激反应、恶性疾病、新血管形成和伤口愈合。SIBLING是本质上非结构化的蛋白质，其具有结合多种受体（CD 44变体和整联蛋白）、细胞外基质组分和蛋白酶的能力。由于广泛的分子相互作用以及骨桥蛋白似乎发挥重要作用的科学学科，来自不同背景的研究人员将通过分享研究设计，方法和实验结果的进展而受益。会议的目标是：召集一个国际小组，其中包括OPN生物学方面的知名专家以及初级科学家。通过多学科的介绍，确定了OPN在正常生理功能和疾病病理学方面的最新知识。促进多个领域（生物化学，细胞生物学，分子生物学，肿瘤学，免疫学，血管和骨生物学）的交叉施肥，以及初级科学家接触跨学科和转化研究。在OPN作为病理状态的标志物和作为干预的治疗靶点的发展中激发翻译合作。 公共卫生相关性：骨桥蛋白是一种多功能蛋白质，其在正常发育以及人类疾病进展中的作用在许多不同的科学领域中进行了研究。本次会议将汇集来自广泛学科的科学家，讨论骨桥蛋白和相关蛋白在正常生理学中的作用的现有知识，以及它们作为多发性硬化症，类风湿性关节炎和癌症等疾病治疗靶点的潜力。