Core-002-Biostatistical Core

Core-002-生物统计核心

• 批准号: 10728897
• 负责人: Denise Esserman
• 金额: $ 20.82万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728897
• 关键词: Address; Aging; Algorithms; American; Applications Grants; Basic Science; Bayesian Method; Biometry; Biostatistical Methods; Biostatistics Core; Capsicum; Clinical; Clinical Investigator; Clinical Research; Clinical Trials Design; Clinical and Translational Science Awards; Code; Collaborations; Complement; Data; Data Science; Development; Elderly; Engineering; Ensure; Epidemiologist; Epidemiology; Extramural Activities; Faculty; Funding; Genetic Complementation Test; Goals; Grant; Health Promotion; Home; International; Intervention; Knowledge; Leadership; Machine Learning; Mediation; Medical; Mentors; Mentorship; Methodology; Methods; Mission; Outcome; Outcome Assessment; Peer Review; Personal Satisfaction; Postdoctoral Fellow; Pragmatic clinical trial; Procedures; Productivity; Publications; Quality Control; Reproducibility; Reproducibility of Results; Research; Research Design; Research Personnel; Resources; Role; Science; Services; Statistical Methods; Techniques; Time; Training; Translational Research; Treatment Efficacy; Work; clinical implementation; cost; design; econometrics; efficacy evaluation; experience; implementation science; innovation; lectures; meetings; member; next generation; novel; novel strategies; operation; primary outcome; programs; research study; skills; therapy design; web site

The overarching goals of the Biostatistics Core (BC), RC-2, are to provide design and analytical services to investigators conducting studies of multifactorial geriatric conditions; to develop and disseminate new design and analytical techniques for conducting studies with older persons; and to train a cadre of clinical investigators, biostatisticians, and epidemiologists in the skills necessary to design, conduct, and analyze gerontologic studies. The BC provides state-of-the-art research design and biostatistical expertise for the Yale OAIC with the following specific aims: 1) to collaborate with REC Scholars and other REC trainees, PES investigators, Operations Core (OC) colleagues, and investigators of External Projects to achieve the mission of the Yale OAIC in promoting the understanding and management of multifactorial geriatric conditions; 2) to develop new and rigorous methods that address the challenges of designing and analyzing studies in basic, translational, and clinical geriatric/aging research, with special emphasis on introducing rigorous statistical methods; and 3) to train the next generation of gerontologic biostatisticians, epidemiologists, and early-stage investigators in Gerontologic Biostatistical Methods specific to studies of multifactorial geriatric conditions. To achieve these aims and ensure that OAIC investigators continue to stay at the forefront of methodologically rigorous research, we have formalized a partnership with the Yale Center for Analytical Sciences (YCAS), a center for collaborative science that serves as the Biostatistics and Epidemiologic core of the Yale Clinical and Translational Sciences Award (CTSA). This partnership boosts the reach of the BC in two important ways. First, it expands the resources available to our REC trainees and other OAIC investigators by providing access to additional expertise and mentorship. Second, it brings a wealth of experience in newer approaches that complement the techniques previously available to OAIC investigators. Productivity of the BC during the current funding cycle has been high, as evidenced by nearly 200 peer-reviewed publications and collaboration on 73 successfully funded extramural grants (>$123.4 million total costs) and on 13 pending grant applications representing more than $13 million. The proposed Biostatistics Core’s Development Project (DP-2) focuses on designing pragmatic clinical trials with multivariate outcomes. The project is innovative because such trials, which are becoming increasingly common, often do not take the correlation between outcomes into account in the design and/or analysis, leading to less efficient designs and to estimates that fail to demonstrate the efficacy of treatments. This is especially important for trials that include multiple primary outcomes assessing various aspects of a multifactorial condition or intervention. The code from this and all novel methods developed by the BC will be made publicly available, including through the Gerontologic Research Algorithms and Statistical Programs (GRASP) website.

生物统计核心(BC)RC-2的总体目标是提供设计和分析服务，以 研究人员进行多因素老年疾病研究；开发和传播新设计 与老年人进行研究的分析技术；以及培训临床干部 研究人员、生物统计学家和流行病学家掌握必要的设计、实施和分析技能 老年学研究。卑诗省为耶鲁大学提供最先进的研究设计和生物统计学专业知识 OAIC的具体目标如下：1)与REC学者和其他REC学员、PES合作 调查员、运营核心(OC)同事和外部项目调查员完成任务 耶鲁OAIC在促进对多因素老年疾病的了解和管理方面的作用；2) 开发新的严谨的方法，以应对设计和分析基础、 翻译和临床老年/老龄化研究，特别强调引入严格的统计 方法；3)培训下一代老年学生物统计学家、流行病学家和早期 老年学生物统计学方法的研究人员，专门研究多因素老年疾病。 为了实现这些目标，并确保审查处调查人员继续站在方法学的前沿 严格的研究，我们已经正式与耶鲁大学分析科学中心(YCAS)建立了合作伙伴关系， 合作科学中心，作为耶鲁大学临床和流行病学中心的生物统计学和流行病学核心 翻译科学奖(CTSA)。这种伙伴关系在两个重要方面提升了卑诗省的影响力。 首先，它通过为我们的REC学员和其他OAIC调查人员提供访问权限，扩大了可用的资源 更多的专业知识和指导。其次，它在新方法方面带来了丰富的经验， 补充OAIC调查人员以前可用的技术。不列颠哥伦比亚省的生产力 目前的供资周期很高，近200份同行审查的出版物和合作证明了这一点 关于73项成功资助的校外赠款(总费用为1.234亿美元)和13项待批赠款申请 相当于1300多万美元。 拟议的生物统计学核心开发项目(DP-2)侧重于设计实用的临床试验 具有多变量的结果。该项目具有创新性，因为这样的试验越来越多地 通常，在设计和/或分析中通常不考虑结果之间的相关性， 导致效率较低的设计和未能证明治疗效果的估计。这是 对于包括评估不同方面的多个主要结果的试验尤其重要 多因素的条件或干预。此代码和BC开发的所有新方法的代码将是 公开提供，包括通过老年学研究算法和统计方案 (GRAPH)网站。