Expansion of the 'Getting Started in Cryo-EM' course into a comprehensive theory and practice curriculum
将“冷冻电镜入门”课程扩展为综合理论和实践课程
基本信息
- 批准号:10798674
- 负责人:
- 金额:$ 5.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Project Summary
Cryogenic electron microscopy (cryo-EM) is a rapidly emerging technology for structural biology. While
excitement and demand for the technology are high, the pace of training cryo-EM practitioners lags far behind.
There are two major hurdles to the development of effective training programs: (1) potential learners come
from a wide range of backgrounds and career stages, from graduate students to established structural
biologists; and (2) learning cryo-EM requires many hours of hands-on “behind the wheel” training on
specialized, expensive equipment that is often unavailable to learners at their home institutions. While some
hands-on schools exist for cryoEM, they train only a handful of students a year, while demand for the
technique requires orders of magnitude more. Workshops enroll more students, but are too short to teach all
the necessary theory and lack a hands-on component. To train a skilled workforce of cryo-EM practitioners,
here I propose to expand upon my successful “Getting Started in Cryo-EM” video lectures and create a
comprehensive online curriculum covering the theory and practice of all major cryo-EM modalities including
cryo-EM single particle reconstruction (SPR), electron cryotomography (cryo-ET) and microcrystal electron
diffraction (micro-ED). This curriculum will include many tens of hours of new videos and also the supporting
materials needed to maximize the usefulness of these videos. More specifically, my colleagues and I will
produce new videos teaching the theory and practice of cryo-ET (including special sample prep issues like
correlated light and electron microscopy and cryo-FIB milling), micro-ED, and facility management/advanced
topics. We will also produce videos that introduce basic principles of cryo-EM image processing and prepare
students to move from our materials to the specialized tutorials already available for several popular image
processing packages. We will also create supporting materials including homework problems, open-ended and
multiple-choice exam questions, training manuals with specific standardized practice exercises, and plans for
training programs. Together with staff from the national cryo-EM service centers and my fellow curriculum
development program awardees, I will work to develop a “merit badge” system to certify cryo-EM practitioners
on specific skills and instruments. Materials will be designed in modules that can be mixed and matched to
meet the specific needs of the learner. In conjunction with supervised training at a user’s home facility or
national cryo-EM service center, the curriculum will offer everything a student needs to understand the theory
of, and begin practicing, their desired cryo-EM technique.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GRANT J JENSEN其他文献
GRANT J JENSEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GRANT J JENSEN', 18)}}的其他基金
Expansion of the ‘Getting Started in Cryo-EM’ course into a comprehensive theory and practice curriculum
将“Cryo-EM 入门”课程扩展为综合理论和实践课程
- 批准号:
10223807 - 财政年份:2021
- 资助金额:
$ 5.18万 - 项目类别:
Expansion of the 'Getting Started in Cryo-EM' course into a comprehensive theory and practice curriculum
将“冷冻电镜入门”课程扩展为综合理论和实践课程
- 批准号:
10834296 - 财政年份:2021
- 资助金额:
$ 5.18万 - 项目类别:
Expansion of the ‘Getting Started in Cryo-EM’ course into a comprehensive theory and practice curriculum
将“Cryo-EM 入门”课程扩展为综合理论和实践课程
- 批准号:
10437759 - 财政年份:2021
- 资助金额:
$ 5.18万 - 项目类别:
Imaging large macromolecular complexes inside cells with electron cryotomography
使用电子冷冻断层扫描对细胞内的大分子复合物进行成像
- 批准号:
10013429 - 财政年份:2017
- 资助金额:
$ 5.18万 - 项目类别:
Structure and function of pathogenesis-associated bacterial structures by electron cryotomography
通过电子冷冻断层扫描研究发病机制相关细菌结构的结构和功能
- 批准号:
9765150 - 财政年份:2016
- 资助金额:
$ 5.18万 - 项目类别:
Structure and Function of Pathogenesis-Associated Bacterial Structures by Electron Cryotomography
通过电子冷冻断层扫描研究发病机制相关细菌结构的结构和功能
- 批准号:
10604243 - 财政年份:2016
- 资助金额:
$ 5.18万 - 项目类别:
Structure and function of pathogenesis-associated bacterial structures by electron cryotomography
通过电子冷冻断层扫描研究发病机制相关细菌结构的结构和功能
- 批准号:
9357518 - 财政年份:2016
- 资助金额:
$ 5.18万 - 项目类别:
相似海外基金
Project GANESHA - Getting power Access to rural-Nepal through thermally cooled battery Energy storage for transport and Home Applications
GANESHA 项目 - 通过热冷却电池为尼泊尔农村地区提供电力 用于运输和家庭应用的储能
- 批准号:
10085992 - 财政年份:2024
- 资助金额:
$ 5.18万 - 项目类别:
Collaborative R&D
Getting to the Heart of Domestic Abuse: Identifying the molecular mechanisms of heart disease in association with physical and psychological stress
深入了解家庭暴力的核心:确定心脏病与身体和心理压力相关的分子机制
- 批准号:
486978 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Operating Grants
Generative scenarios for getting Transport to an equitable Net Zero - flipping modelling on its head using Machine Learning
让运输实现公平的净零排放的生成场景 - 使用机器学习颠覆模型
- 批准号:
2868504 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Studentship
Simulating Plankton - getting it right in the era of Digital Twins of The Ocean
模拟浮游生物 - 在海洋数字孪生时代取得成功
- 批准号:
NE/X010783/1 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Research Grant
Getting a flavour for New Physics with precision measurements of tree-level beauty decays
通过精确测量树级美丽衰减来体验新物理学
- 批准号:
ST/R004536/3 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Fellowship
SCC-PG: Getting the Edge on Data-Driven Self-Managed Care: A Focus on Older Veterans in Arizona
SCC-PG:在数据驱动的自我管理护理方面取得优势:关注亚利桑那州的老年退伍军人
- 批准号:
2231874 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Standard Grant
Getting the green light: How chloroplast gene expression is activated by light
获得批准:叶绿体基因表达如何被光激活
- 批准号:
2869544 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Studentship
Follow-up study of special driving course participants who have difficulty getting a driver's license
特殊驾驶课程考取驾驶证困难学员跟踪研究
- 批准号:
23K16570 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Realization of a wireless power transfer system insensitive to lossy obstacles getting into the transmission path
实现对进入传输路径的有损障碍物不敏感的无线电力传输系统
- 批准号:
23K03818 - 财政年份:2023
- 资助金额:
$ 5.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)