Expansion of the 'Getting Started in Cryo-EM' course into a comprehensive theory and practice curriculum

将“冷冻电镜入门”课程扩展为综合理论和实践课程

基本信息

  • 批准号:
    10798674
  • 负责人:
  • 金额:
    $ 5.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-01 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

Project Summary Cryogenic electron microscopy (cryo-EM) is a rapidly emerging technology for structural biology. While excitement and demand for the technology are high, the pace of training cryo-EM practitioners lags far behind. There are two major hurdles to the development of effective training programs: (1) potential learners come from a wide range of backgrounds and career stages, from graduate students to established structural biologists; and (2) learning cryo-EM requires many hours of hands-on “behind the wheel” training on specialized, expensive equipment that is often unavailable to learners at their home institutions. While some hands-on schools exist for cryoEM, they train only a handful of students a year, while demand for the technique requires orders of magnitude more. Workshops enroll more students, but are too short to teach all the necessary theory and lack a hands-on component. To train a skilled workforce of cryo-EM practitioners, here I propose to expand upon my successful “Getting Started in Cryo-EM” video lectures and create a comprehensive online curriculum covering the theory and practice of all major cryo-EM modalities including cryo-EM single particle reconstruction (SPR), electron cryotomography (cryo-ET) and microcrystal electron diffraction (micro-ED). This curriculum will include many tens of hours of new videos and also the supporting materials needed to maximize the usefulness of these videos. More specifically, my colleagues and I will produce new videos teaching the theory and practice of cryo-ET (including special sample prep issues like correlated light and electron microscopy and cryo-FIB milling), micro-ED, and facility management/advanced topics. We will also produce videos that introduce basic principles of cryo-EM image processing and prepare students to move from our materials to the specialized tutorials already available for several popular image processing packages. We will also create supporting materials including homework problems, open-ended and multiple-choice exam questions, training manuals with specific standardized practice exercises, and plans for training programs. Together with staff from the national cryo-EM service centers and my fellow curriculum development program awardees, I will work to develop a “merit badge” system to certify cryo-EM practitioners on specific skills and instruments. Materials will be designed in modules that can be mixed and matched to meet the specific needs of the learner. In conjunction with supervised training at a user’s home facility or national cryo-EM service center, the curriculum will offer everything a student needs to understand the theory of, and begin practicing, their desired cryo-EM technique.
项目总结

项目成果

期刊论文数量(0)
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专利数量(0)

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{{ truncateString('GRANT J JENSEN', 18)}}的其他基金

Expansion of the ‘Getting Started in Cryo-EM’ course into a comprehensive theory and practice curriculum
将“Cryo-EM 入门”课程扩展为综合理论和实践课程
  • 批准号:
    10223807
  • 财政年份:
    2021
  • 资助金额:
    $ 5.18万
  • 项目类别:
Expansion of the 'Getting Started in Cryo-EM' course into a comprehensive theory and practice curriculum
将“冷冻电镜入门”课程扩展为综合理论和实践课程
  • 批准号:
    10834296
  • 财政年份:
    2021
  • 资助金额:
    $ 5.18万
  • 项目类别:
Expansion of the ‘Getting Started in Cryo-EM’ course into a comprehensive theory and practice curriculum
将“Cryo-EM 入门”课程扩展为综合理论和实践课程
  • 批准号:
    10437759
  • 财政年份:
    2021
  • 资助金额:
    $ 5.18万
  • 项目类别:
Imaging large macromolecular complexes inside cells with electron cryotomography
使用电子冷冻断层扫描对细胞内的大分子复合物进行成像
  • 批准号:
    10013429
  • 财政年份:
    2017
  • 资助金额:
    $ 5.18万
  • 项目类别:
Structure and function of pathogenesis-associated bacterial structures by electron cryotomography
通过电子冷冻断层扫描研究发病机制相关细菌结构的结构和功能
  • 批准号:
    9765150
  • 财政年份:
    2016
  • 资助金额:
    $ 5.18万
  • 项目类别:
Structure and Function of Pathogenesis-Associated Bacterial Structures by Electron Cryotomography
通过电子冷冻断层扫描研究发病机制相关细菌结构的结构和功能
  • 批准号:
    10604243
  • 财政年份:
    2016
  • 资助金额:
    $ 5.18万
  • 项目类别:
Structure and function of pathogenesis-associated bacterial structures by electron cryotomography
通过电子冷冻断层扫描研究发病机制相关细菌结构的结构和功能
  • 批准号:
    9357518
  • 财政年份:
    2016
  • 资助金额:
    $ 5.18万
  • 项目类别:
Structural Basis of Chemoreception
化学感受的结构基础
  • 批准号:
    8643266
  • 财政年份:
    2013
  • 资助金额:
    $ 5.18万
  • 项目类别:
Structural Basis of Chemoreception
化学感受的结构基础
  • 批准号:
    9022486
  • 财政年份:
    2013
  • 资助金额:
    $ 5.18万
  • 项目类别:
Structural Basis of Chemoreception
化学感受的结构基础
  • 批准号:
    8507076
  • 财政年份:
    2013
  • 资助金额:
    $ 5.18万
  • 项目类别:

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