CENTER FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES

传染病结构生物学研究中心

• 批准号: 10697524
• 负责人: PETER MYLER
• 金额: $ 110.53万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10697524
• 关键词: 3-Dimensional; Bacterial Drug Resistance; Basic Science; Biological; Biomedical Research; Communicable Diseases; Gram-Negative Bacteria; Molecular; Proteins; Research; Research Project Grants; Research Support; Role; Structure; Technology; pathogen; programs; structural biology; three dimensional structure

To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins for gram positive and gram negative bacteria. This program also supports research projects that utilize the 3D structure information and experimental approaches to better characterize the molecular functional role of protein targets. The primary focus of the Center is pathogen proteins that are expected to have an important biological role and a potential impact on biomedical research.

应用最先进的高通量结构生物学技术对革兰氏阳性和革兰氏阴性细菌靶蛋白的三维原子结构进行实验表征。该计划还支持利用3D结构信息和实验方法更好地表征蛋白质靶标的分子功能作用的研究项目。该中心的主要重点是病原体蛋白，预计这些蛋白将在生物医学研究中发挥重要的生物学作用和潜在影响。