TASK ORDER 18 - SELF III

这项工作是一项前瞻性研究的延续，该研究是对年轻非裔美国女性中子宫肌瘤危险因素的研究。该研究的三个主要假设是：(1)维生素D缺乏是肌瘤发病的一个危险因素；(2)生殖道感染是肌瘤发生的危险因素；(3)非洲血统比例较高是肌瘤发病的危险因素。两个次要假设包括(1)含有雌激素或类黄体酮活性的化妆品增加肌瘤的风险；(2)产前和早期生活暴露（如早产、先兆子痫、大豆配方奶粉）影响肌瘤的风险。

This work is a continuation of a prospective study of risk factors for fibroids in a population of young African-American women—the SELF Study. The study’s three primary hypotheses are: (1) vitamin D deficiency is a risk factor for fibroid incidence; (2) reproductive tract infection is a risk factor for fibroid incidence and; (3) a higher proportion of African ancestry is a risk factor for fibroid incidence. Two secondary hypotheses include (1) cosmetics with estrogenic or progestin-like activity increase the risk of fibroids and; (2) prenatal and early life exposures (e.g., preterm birth, preeclampsia, soy-based formula) influence risk of fibroids. In addition to testing these hypotheses, the study collected a broad spectrum of information including data on recognized risk factors (e.g., age of menarche, pregnancy history, alcohol use), common exposures with inconsistent risk estimates in the literature (e.g., body mass index, oral contraceptive use), exposures of interest for which there is very limited literature (e.g., diet, exercise), and detailed symptom data, especially menstrual bleeding.