Promoting DEIA in Lung Disease Research Through a Mentored Training Experience at IUB-SPH

项目总结 本行政副刊旨在表彰多样性、公平性、包容性和可获得性方面的卓越表现 (Deia)导师制提案扩展了家长研究的研究目标及其相关的多样性 补充剂，其目的是a)研究性激素促进哮喘的机制 发展和进步，以及b)发现性别和性别影响的基本生物学差异 哮喘表现和预后中的性别。如果得到资助，这项补充奖励将提供10 本科生实习生帮助进行这项研究并参与与文化相关的领导力 开发和研究培训计划。本行政副刊的具体活动将 通过支持一批来自传统代表性不足的学生的职业发展来支持Deia 在STEM领域的背景，同时扩大了家长奖的研究目标。这将是 通过1)培养学生对职业机会的认识，2)增加学生对职业机会的认识 科学研究/发现过程，3)巩固个人的决心、毅力和信心 学生，以及4)让学生在公共场合接触来自不同背景的各种专业人士 健康，以扩大他们的职业选择选择。具体地说，来自全国各地院校的10名学生 美国，以及在STEM中任职人数不足的背景，将被招募参加综合 印第安纳大学布鲁明顿公共学院领导力发展和研究培训项目 健康(IUB-SPH)。该方案的第一阶段将侧重于将开展的队列建设活动 几乎超过3个月，并包括职业发展培训的元素，使他们为 暑期研究经验。该计划的第二阶段将包括为期8周的面对面暑期。 在IUB-SPH的研究密集体验，学生将参加a)密集的面对面 个人领导力发展计划，b)动手实验室技术培训，c)完成 一项旨在表征促炎基因表达的性别差异的独立研究项目 由原代人支气管上皮细胞中的过敏原暴露触发，以及检测新的性别- 应用免疫学复合技术检测肺上皮过敏性炎症的特异性蛋白生物标志物 分析技术平台。类似于父级奖项及其相关的多样性补充，这 通过调查病理生物学，行政补充与NHLBI的研究重点很好地结合在一起 对肺部疾病的发生和发展很重要的机制，确定解释 肺部疾病病理生物学的个体差异，包括性别差异和性别的影响，以及 培养、多样化和维持一支能够完成研究所使命的科学队伍。

PROJECT SUMMARY This Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship proposal expands on the research goals of parent study and its associated diversity supplement, which aim to a) investigate the mechanisms by which gonadal sex hormones contribute to asthma development and progression, and b) discover basic biological differences underlying the influence of sex and gender in asthma presentation and outcomes. If funded, this supplement award will provide support for 10 undergraduate student trainees to help conduct this research and participate in a culturally relevant leadership development and research training program. The specific activities of this administrative supplement will support DEIA by supporting the career development of a cohort of students from traditionally underrepresented backgrounds in STEM fields, while expanding the research goals of the parent award. This will be accomplished by 1) building student awareness of career opportunities, 2) increasing student knowledge of the science research/discovery process, 3) cementing individual resolve, perseverance and confidence in students, and 4) exposing students to a variety of professionals from a multitude of backgrounds in public health to expand their options for career selection. Specifically, a cohort of 10 students from institutions across the United States, and from backgrounds underrepresented in STEM, will be recruited for an integrated leadership development and research training program at Indiana University Bloomington School of Public Health (IUB-SPH). The first phase of the program will focus on cohort-building activities that will be conducted virtually over 3-months, and include elements of career development training that will prepare them for a summer research experience. The second phase of the program will consist of an 8-week in-person summer research intensive experience at IUB-SPH, where students will participate in a) an intensive in-person individual leadership development program, b) a hands-on laboratory techniques training, c) the completion of an independent research project aimed to characterize sex differences in pro-inflammatory gene expression triggered by allergen exposure in primary human bronchial epithelial cells, as well as to detect novel sex- specific protein biomarkers for allergic inflammation in the lung epithelium using an immunology multiplex analysis technology platform. Similar to the parent award and its associated diversity supplement, this administrative supplement is well-aligned with the research priorities of NHLBI by investigating pathobiological mechanisms important to the onset and progression of lung diseases, identifying factors that account for individual differences in lung disease pathobiology, including sex differences and the influence of sex, and developing, diversifying, and sustaining a scientific workforce capable of accomplishing the institute’s mission.