Promoting DEIA in Lung Disease Research Through a Mentored Training Experience at IUB-SPH

通过 IUB-SPH 的指导培训经验促进 DEIA 在肺部疾病研究中的应用

• 批准号: 10792180
• 负责人: Patricia Silveyra
• 金额: $ 39.62万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-10 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10792180
• 关键词: Accounting; Administrative Supplement; Adverse effects; Affect; Agonist; Air; Allergens; Allergic inflammation; Androgen Receptor; Androgens; Animal Model; Anti-Inflammatory Agents; Asthma; Award; Biological; Cells; Cementation; Development; Diagnosis; Disparity; Elements; Environmental Exposure; Environmental Risk Factor; Epithelial Cells; Epithelium; Estradiol; Estrogen Receptors; Estrogens; Estrous Cycle; Exposure to; Female; Four Core Genotypes; Funding; Gender; Gene Expression; Gene Expression Profile; Genetic Transcription; Goals; Gonadal Hormones; Gonadal Steroid Hormones; Graduate Education; Growth Factor; Harvest; Health; Hormone Receptor; Hormones; Human; Immune; Immunology; Indiana; Individual; Individual Differences; Inflammation; Inflammatory; Inflammatory Response; Inhalation; Institution; Internships; Investigation; Knowledge; Laboratories; Leadership; Life; Liquid substance; Lung; Lung diseases; Mediating; Mentors; Mentorship; Mission; Modeling; Molecular; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Parents; Participant; Pathway Analysis; Patients; Persons; Phase; Physiological; Predisposition; Prevalence; Prevention; Process; Progesterone; Progesterone Receptors; Program Development; Puberty; Public Health; Public Health Schools; Pulmonary Inflammation; Pyroglyphidae; RNA; Reporting; Research; Research Priority; Research Project Grants; Research Training; Respiratory Disease; Risk; STEM field; STEM research; Science; Severities; Sex Chromosomes; Sex Differences; Signal Transduction; Stanolone; Stimulus; Students; System; Testing; Training; Training Programs; Training Technics; United States; Universities; Woman; Work; airway epithelium; antagonist; asthma exacerbation; asthmatic; asthmatic patient; bronchial epithelium; career; career awareness; career development; chemokine; cohort; cytokine; design; equity, diversity, and inclusion; experience; experimental study; female sex hormone; in vivo; inflammatory lung disease; leadership development; male; male sex hormones; men; middle age; mouse model; multiplex assay; novel; prevent; programs; protein biomarkers; protein expression; pulmonary function; pulmonary symptom; receptor; recruit; response; sex; specific biomarkers; summer research; technology platform; undergraduate student; virtual

PROJECT SUMMARY This Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship proposal expands on the research goals of parent study and its associated diversity supplement, which aim to a) investigate the mechanisms by which gonadal sex hormones contribute to asthma development and progression, and b) discover basic biological differences underlying the influence of sex and gender in asthma presentation and outcomes. If funded, this supplement award will provide support for 10 undergraduate student trainees to help conduct this research and participate in a culturally relevant leadership development and research training program. The specific activities of this administrative supplement will support DEIA by supporting the career development of a cohort of students from traditionally underrepresented backgrounds in STEM fields, while expanding the research goals of the parent award. This will be accomplished by 1) building student awareness of career opportunities, 2) increasing student knowledge of the science research/discovery process, 3) cementing individual resolve, perseverance and confidence in students, and 4) exposing students to a variety of professionals from a multitude of backgrounds in public health to expand their options for career selection. Specifically, a cohort of 10 students from institutions across the United States, and from backgrounds underrepresented in STEM, will be recruited for an integrated leadership development and research training program at Indiana University Bloomington School of Public Health (IUB-SPH). The first phase of the program will focus on cohort-building activities that will be conducted virtually over 3-months, and include elements of career development training that will prepare them for a summer research experience. The second phase of the program will consist of an 8-week in-person summer research intensive experience at IUB-SPH, where students will participate in a) an intensive in-person individual leadership development program, b) a hands-on laboratory techniques training, c) the completion of an independent research project aimed to characterize sex differences in pro-inflammatory gene expression triggered by allergen exposure in primary human bronchial epithelial cells, as well as to detect novel sex- specific protein biomarkers for allergic inflammation in the lung epithelium using an immunology multiplex analysis technology platform. Similar to the parent award and its associated diversity supplement, this administrative supplement is well-aligned with the research priorities of NHLBI by investigating pathobiological mechanisms important to the onset and progression of lung diseases, identifying factors that account for individual differences in lung disease pathobiology, including sex differences and the influence of sex, and developing, diversifying, and sustaining a scientific workforce capable of accomplishing the institute’s mission.

项目摘要 这一行政补充，以表彰卓越的多样性，公平，包容性，和可访问性 （DEIA）导师计划扩展了父母研究及其相关多样性的研究目标 补充，其目的是a）研究性腺性激素导致哮喘的机制 发展和进展，和B）发现基本的生物学差异的影响，性别和 哮喘表现和结果中的性别。如果获得资助，该补充奖将为10个 本科生学员，以帮助进行这项研究，并参与文化相关的领导 发展和研究培训计划。本行政补充文件的具体活动将 通过支持传统上代表性不足的学生群体的职业发展来支持DEIA STEM领域的背景，同时扩大了家长奖的研究目标。这将是 完成1）建立学生的职业机会意识，2）增加学生的知识， 科学研究/发现过程，3）巩固个人的决心，毅力和信心， 学生，以及4）让学生在公共场合接触来自多种背景的各种专业人士 健康，以扩大他们的职业选择的选择。具体来说，来自全国各地机构的10名学生组成的队列 美国，以及来自STEM代表性不足的背景，将被招募参加一个综合的 印第安纳州大学布卢明顿公共学院领导力发展和研究培训项目 健康（IUB-SPH）。该计划的第一阶段将侧重于将进行的群体建设活动， 几乎超过3个月，并包括职业发展培训的内容，这将使他们为未来的工作做好准备。 暑期研究经验该计划的第二阶段将包括为期8周的亲自夏季 在IUB-SPH的研究密集型经验，学生将参加a）密集的面对面 个人领导力发展计划，B）动手实验室技术培训，c）完成 一个独立的研究项目，旨在表征促炎基因表达的性别差异， 由原代人支气管上皮细胞中的过敏原暴露引发，以及检测新的性别- 使用免疫学多重检测肺上皮中变应性炎症的特异性蛋白质生物标志物 分析技术平台。类似于母公司奖及其相关的多元化补充， 行政补充与NHLBI的研究重点是通过调查病理生物学 对肺部疾病的发生和进展很重要的机制，确定导致 肺部疾病病理生物学的个体差异，包括性别差异和性别的影响，以及 发展、多样化和维持一支能够完成研究所使命的科学队伍。