Mentoring Underrepresented Researchers in Diabetes and Pregnancy Investigation

指导糖尿病和妊娠调查中代表性不足的研究人员

• 批准号: 10796029
• 负责人: Camille Elise Powe
• 金额: $ 13.23万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796029
• 关键词: Address; Affect; Award; Biomedical Research; Black race; Blood Glucose; Boston; Caring; Cell Cycle Kinetics; Child; Clinical Research; Collaborations; Continuous Glucose Monitor; Data; Data Set; Diabetes Mellitus; Diagnosis; Discipline of obstetrics; Disease; Endocrinologist; Environment; Erythrocytes; Event; Exclusion; Faculty; Fellowship; Fetal Growth; Functional disorder; Funding; Future; General Hospitals; Generations; Gestational Diabetes; Glycosylated hemoglobin A; Goals; Grant; Health; Home; Hour; Hyperglycemia; Hypertension; Individual; Institution; Insulin; Investigation; K-Series Research Career Programs; Knowledge; Lactation; Massachusetts; Mentors; Mentorship; Metabolic; Metabolic Diseases; Minority Groups; Modeling; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Persons; Physicians; Physiological; Population; Postdoctoral Fellow; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy in Diabetics; Premature Birth; Principal Investigator; Professional Organizations; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Scientist; System; Techniques; Technology; Therapeutic; Training; Training Programs; Underrepresented Populations; United States National Institutes of Health; Weight; cardiometabolic risk; cardiovascular risk factor; career; cohort; design; diabetes risk; early pregnancy; genetic architecture; genetic profiling; graduate student; improved; innovation; marginalized population; medical schools; metabolic abnormality assessment; minority investigator; neonatal morbidity; novel; novel strategies; patient oriented; pregnancy disorder; pregnant; programs; recruit; research study

ABSTRACT Hyperglycemia is a common metabolic problem with a profound impact on pregnancy outcomes. Even modest elevations in blood glucose during gestation are associated with a multitude of pregnancy complications, including fetal growth abnormalities, hypertensive disorders of pregnancy, preterm birth, and neonatal morbidity. Manifestation of metabolic disease in pregnancy foreshadows future diabetes and cardiovascular risk in both affected individuals and their children. Over the past two decades, there have been remarkable advances in understanding of diabetes pathophysiology, application of diabetes technology, and novel diabetes therapeutics. Yet, many these innovations have not reached the obstetric population, in part because of the by-default exclusion of pregnant and lactating individuals from clinical research studies. To address this problem, we need to train a new generation of diabetes researchers that has the expertise to rigorously conduct studies in pregnancy. This new generation of investigators should reflect the diversity of the people affected by hyperglycemia, who are disproportionately from minoritized and marginalized groups. The Principal Investigator (PI) has a longstanding commitment to mentoring future physicians and scientists, with a special emphasis on trainees that are from backgrounds underrepresented in biomedical research. The goal of this proposal is to support the PI’s high-quality mentorship of graduate students and postdoctoral fellows from underrepresented backgrounds in diabetes and pregnancy investigation. The PI’s interdisciplinary NIH-funded research program applies advances in physiologic and genetic profiling, as well as diabetes technologies, to improve the understanding of glycemia in pregnancy and inform new approaches to the care of pregnant and lactating individuals with diabetes. The PI has had continuous NIDDK funding since joining the faculty of Massachusetts General Hospital and Harvard Medical School. Her funded research projects and other available datasets provide a rich training-ground for mentee projects in the investigation of diabetes, metabolic disease, and other related disorders in pregnancy. During the grant period the PI will RECRUIT (Aim 1), TRAIN (Aim 2), SUPPORT (Aim 3), and SPONSOR (Aim 4) at least 8 trainees at the graduate student or postdoctoral fellow level from underrepresented backgrounds. With access to exceptional institutional resources and the PI’s scientific program, mentees will succeed in building independent research careers and deliver biomedical advances in diabetes to pregnant and lactating individuals.

摘要 高血压是一种常见的代谢问题，对妊娠结局有着深远的影响。即使是温和 妊娠期间血糖升高与多种妊娠并发症有关， 包括胎儿生长异常、妊娠期高血压疾病、早产和新生儿 发病率妊娠期代谢性疾病的表现预示着未来的糖尿病和心血管疾病 受影响的个人及其子女的风险。在过去的二十年里， 糖尿病病理生理学的理解进展，糖尿病技术的应用， 糖尿病治疗学然而，许多这些创新并没有达到产科人口，部分原因是 默认情况下将妊娠和哺乳期个体排除在临床研究之外。为了解决这个 问题，我们需要培养新一代的糖尿病研究人员，他们拥有严格的专业知识， 在怀孕期间进行研究。新一代的调查人员应该反映出人民的多样性 受高血糖症影响的儿童中，少数群体和边缘化群体所占比例过高。 主要研究者（PI）长期致力于指导未来的医生和科学家， 特别强调来自生物医学研究背景不足的学员。的 本提案的目标是支持PI对研究生和博士后的高质量指导 糖尿病和妊娠研究领域代表性不足的研究员。PI的跨学科 美国国立卫生研究院资助的研究项目应用了生理和遗传特征分析以及糖尿病方面的进展 技术，以提高对妊娠期流产的认识，并为新的护理方法提供信息， 糖尿病孕妇和哺乳期患者的治疗。PI自加入以来一直获得NIDDK的资助， 马萨诸塞州总医院和哈佛医学院的教员。她资助的研究项目和 其他可用的数据集为糖尿病研究中的学员项目提供了丰富的训练基础， 代谢疾病和其他妊娠相关疾病。 在资助期间，PI将在以下地点招募（目标1）、培训（目标2）、支持（目标3）和赞助商（目标4）： 至少8名来自任职人数不足背景的研究生或博士后研究员级别的受训人员。与 获得特殊的机构资源和PI的科学计划，学员将成功地建立 独立的研究事业，并提供糖尿病的生物医学进步，孕妇和哺乳期 个体