Mentoring Underrepresented Researchers in Diabetes and Pregnancy Investigation

指导糖尿病和妊娠调查中代表性不足的研究人员

• 批准号: 10796029
• 负责人: Camille Elise Powe
• 金额: $ 13.23万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796029
• 关键词: Address; Affect; Award; Biomedical Research; Black race; Blood Glucose; Boston; Caring; Cell Cycle Kinetics; Child; Clinical Research; Collaborations; Continuous Glucose Monitor; Data; Data Set; Diabetes Mellitus; Diagnosis; Discipline of obstetrics; Disease; Endocrinologist; Environment; Erythrocytes; Event; Exclusion; Faculty; Fellowship; Fetal Growth; Functional disorder; Funding; Future; General Hospitals; Generations; Gestational Diabetes; Glycosylated hemoglobin A; Goals; Grant; Health; Home; Hour; Hyperglycemia; Hypertension; Individual; Institution; Insulin; Investigation; K-Series Research Career Programs; Knowledge; Lactation; Massachusetts; Mentors; Mentorship; Metabolic; Metabolic Diseases; Minority Groups; Modeling; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Persons; Physicians; Physiological; Population; Postdoctoral Fellow; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy in Diabetics; Premature Birth; Principal Investigator; Professional Organizations; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Scientist; System; Techniques; Technology; Therapeutic; Training; Training Programs; Underrepresented Populations; United States National Institutes of Health; Weight; cardiometabolic risk; cardiovascular risk factor; career; cohort; design; diabetes risk; early pregnancy; genetic architecture; genetic profiling; graduate student; improved; innovation; marginalized population; medical schools; metabolic abnormality assessment; minority investigator; neonatal morbidity; novel; novel strategies; patient oriented; pregnancy disorder; pregnant; programs; recruit; research study

ABSTRACT Hyperglycemia is a common metabolic problem with a profound impact on pregnancy outcomes. Even modest elevations in blood glucose during gestation are associated with a multitude of pregnancy complications, including fetal growth abnormalities, hypertensive disorders of pregnancy, preterm birth, and neonatal morbidity. Manifestation of metabolic disease in pregnancy foreshadows future diabetes and cardiovascular risk in both affected individuals and their children. Over the past two decades, there have been remarkable advances in understanding of diabetes pathophysiology, application of diabetes technology, and novel diabetes therapeutics. Yet, many these innovations have not reached the obstetric population, in part because of the by-default exclusion of pregnant and lactating individuals from clinical research studies. To address this problem, we need to train a new generation of diabetes researchers that has the expertise to rigorously conduct studies in pregnancy. This new generation of investigators should reflect the diversity of the people affected by hyperglycemia, who are disproportionately from minoritized and marginalized groups. The Principal Investigator (PI) has a longstanding commitment to mentoring future physicians and scientists, with a special emphasis on trainees that are from backgrounds underrepresented in biomedical research. The goal of this proposal is to support the PI’s high-quality mentorship of graduate students and postdoctoral fellows from underrepresented backgrounds in diabetes and pregnancy investigation. The PI’s interdisciplinary NIH-funded research program applies advances in physiologic and genetic profiling, as well as diabetes technologies, to improve the understanding of glycemia in pregnancy and inform new approaches to the care of pregnant and lactating individuals with diabetes. The PI has had continuous NIDDK funding since joining the faculty of Massachusetts General Hospital and Harvard Medical School. Her funded research projects and other available datasets provide a rich training-ground for mentee projects in the investigation of diabetes, metabolic disease, and other related disorders in pregnancy. During the grant period the PI will RECRUIT (Aim 1), TRAIN (Aim 2), SUPPORT (Aim 3), and SPONSOR (Aim 4) at least 8 trainees at the graduate student or postdoctoral fellow level from underrepresented backgrounds. With access to exceptional institutional resources and the PI’s scientific program, mentees will succeed in building independent research careers and deliver biomedical advances in diabetes to pregnant and lactating individuals.

摘要 高血糖是一种常见的代谢问题，对妊娠结局有深远的影响。即使是谦虚 妊娠期血糖升高与多种妊娠并发症有关， 包括胎儿发育异常、妊娠高血压疾病、早产和新生儿 发病率。妊娠期间代谢性疾病的表现预示着未来的糖尿病和心血管疾病 在受影响的个人及其子女中都存在风险。在过去的二十年里，有值得注意的 糖尿病病理生理学研究进展、糖尿病技术应用及新进展 糖尿病治疗学。然而，许多这些创新并没有惠及产科人群，部分原因是 默认情况下，将孕妇和哺乳期个人排除在临床研究之外。要解决这个问题 我们需要培养新一代糖尿病研究人员，他们拥有严格的 在怀孕期间进行研究。新一代调查人员应该反映人民的多样性 受高血糖影响，这些人不成比例地来自小型化和边缘化群体。 首席调查员(PI)长期致力于指导未来的医生和科学家， 特别强调那些来自生物医学研究中代表性不足的背景的受训者。这个 这项提议的目标是支持PI对研究生和博士后的高质量指导 在糖尿病和怀孕调查中来自代表性不足的背景的研究员。国际和平研究所的跨学科 美国国立卫生研究院资助的研究计划应用于生理和基因图谱以及糖尿病方面的进展 技术，以提高对妊娠期血糖的了解，并提供新的护理方法 怀孕和哺乳期的糖尿病患者。自从加入NIDDK以来，PI一直得到NIDDK的资助 马萨诸塞州总医院和哈佛医学院的教师。她资助的研究项目和 其他可用的数据集为糖尿病调查中的导师项目提供了丰富的培训基础， 代谢性疾病，以及其他与妊娠相关的疾病。 在赠款期间，PI将招聘(目标1)、培训(目标2)、支持(目标3)和赞助商(目标4)。 至少8名研究生或博士后级别的实习生，背景较少。使用 获得特殊的机构资源和PI的科学计划，学员将成功地建立 独立研究事业并向孕妇和哺乳期提供糖尿病生物医学进展 个人。