Facility Management, Maintenance and Operation Core

项目摘要 核心1：设施管理、维护和运营核心 密苏里大学区域生物控制实验室，传染病研究实验室 (LIDR)是一个独立的设施，位于校园东侧，旨在支持对 选择需要生物安全级别3(BSL-3)遏制的病原体。因为安全和安保方面的风险 与这一研究计划相关的是，LIDR遵循严格的现场和建筑安全程序以及 严谨全面的建筑维护计划和强大的人员基础设施进行维护 生物隔离设施的持续运行。设施管理、维护和运营 核心(此UC7应用程序的核心1)负责现场和建筑安全以及所有 建筑系统。BSL-3安全区的运营和管理涉及数十个行业， 需要暖通空调，电信，蒸汽，热水锅炉，校园蒸汽，冷冻水，配电，自然 燃气、应急发电机、二氧化碳分配、水处理和净化、污水净化以及 现场冷水备用冷冻机。将建筑系统与经过测试的紧急情况相结合 程序为所有可能影响安全壳区域和不利的非正常事件提供冗余 影响研究、实验室工作人员和/或环境。维护所需专业知识的广度 建筑系统是由MU校园设施集团提供的，他们在每个领域雇用工匠， 负责预防性维护和维修工作。此外，目前有57家经代理批准的选定机构 个人，以及日常和定期访客，包括建筑维修承包商，翻新 承包商、熟练的贸易人员、管理人员、设施和计划检查员以及来自更广泛领域的用户 慕尼黑大学传染病社区。随着LIDR BSL-3实验室被批准进行精选试剂研究， 现场安全和生物安全计划需要一支致力于设施管理的重要员工队伍。这个 拟议的设施管理、维护和运营核心的目标是增加 LIDR的BSL-3/ACL-3/ABSL-3研究计划的效率，以培训出色的生物遏制 设施劳动力，并通过共享资源和最佳做法为RBL-NBL网络做出贡献 高安全系数设施的管理。为实现这些目标，拟议的核心将与 BSL-3实践核心(核心2)和生物遏制服务和研究资源核心(核心3) 在满足BSL-3和更广泛的研究社区的需求方面提供协同作用，以推动 针对高后果细菌和病毒优先病原体的新医学对策的开发。

Project Summary Core 1: Facilities Management, Maintenance, and Operations Core The University of Missouri Regional Biocontainment Laboratory, the Laboratory for Infectious Disease Research (LIDR) is a stand-alone facility, located in the east side of campus, that was designed to support research on select agent pathogens requiring biosafety level 3 (BSL-3) containment. Because of the safety and security risks associated with this research program, the LIDR follows strict site and building security procedures as well as a rigorous and comprehensive building maintenance schedule and strong personnel infrastructure to maintain continuous operations of the biocontainment facility. The Facilities Management, Maintenance, and Operations Core (Core 1 of this UC7 application) is responsible for site and building security and proper functioning of all building systems. Operations and management of the BSL-3 containment areas involves dozens of trades, needing HVAC, telecom, steam, hot-water boilers, campus steam, chilled water, electrical distribution, natural gas, emergency generator, CO2 distribution, water treatment and purification, effluent decontamination, and an on-site chiller for back-up chilled water. Together the building systems in conjunction with tested emergency procedures provide redundancy for all off-normal events that could impact the containment areas and adversely affect research, laboratory workers, and/or the environment. The breadth of expertise needed to maintain building systems is provided by the MU Campus Facilities group, who employs tradesman in every area that are assigned to preventive maintenance and repair duties. In addition, there are presently 57 select agent-approved individuals, along with daily and periodic visitors including building maintenance contractors, renovation contractors, skilled tradespeople, custodial staff, facility and program inspectors, and users from the broader infectious disease community at MU. As LIDR BSL-3 laboratories are approved for select agent research, the site security and biosafety plans require a significant workforce dedicated to facilities management. The objectives of the proposed Facilities Management, Maintenance, and Operations Core are to increase efficiencies of the BSL-3/ACL-3/ABSL-3 research program at LIDR, to train an outstanding biocontainment facilities workforce, and contribute to the RBL-NBL network by sharing of resources and best practices in the management of high containment facilities. To achieve these goals, the proposed core will work closely with the BSL-3 Practices Core (core 2) and the Biocontainment Services and Research Resources Core (core 3) to provide synergy in meeting the needs of the BSL-3 and broader research communities in order to advance the development of novel medical countermeasures against high consequence bacterial and viral priority pathogens.