BSL-3 Practices Core

BSL-3 实践核心

• 批准号: 10793829
• 负责人: JEFFREY Joseph ADAMOVICZ
• 金额: $ 76.81万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793829
• 关键词: 2019-nCoV; Address; Adopted; Adoption; Aerosols; Area; Attention; Authorization documentation; Basic Science; COVID-19; Certification; Communicable Diseases; Communities; Competence; Complement; Containment; Continuing Education; Core Facility; Decontamination; Diagnostic; Emergency Situation; Emergency response; Emerging Communicable Diseases; Environment; Equipment; Equipment and supply inventories; Exercise; Faculty; Faculty Recruitment; Failure; Family suidae; Goals; Grant; Human Resources; Individual; Infectious Diseases Research; Influenza; Infrastructure; International; Investigation; Investments; Laboratories; Location; Maintenance; Methodology; Mission; Missouri; Modernization; Mutant Strains Mice; National Institute of Allergy and Infectious Disease; Operations Research; Play; Positioning Attribute; Precision Health; Prevention strategy; Principal Investigator; Procedures; Productivity; Public Health; Public Health Schools; Rattus; Readiness; Reporting; Research; Research Personnel; Research Support; Resource Development; Resources; Risk Assessment; Role; Safety; Science; Security; Services; Standardization; Students; Teaching Hospitals; Testing; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vaccines; Variant; Vector-transmitted infectious disease; Work; Workforce Development; authority; base; biocontainment facility; biosafety level 3 facility; emerging pathogen; improved; innovation; insight; institutional biosafety committee; instrumentation; interest; medical schools; meetings; new technology; operation; pandemic preparedness; pandemic response; pathogen; priority pathogen; programs; recruit; research and development; research facility; skills

Project Summary Core 2: Biosafety Level 3 Practices The Biosafety Level 3 Practices Core (BPC) at the Laboratory of Infectious Disease Research (LIDR) includes three major components: Biosafety and emergency planning, user training and competency oversight, and select agent program management. The BPC is integrated within the LIDR program and is positioned to provide LIDR researchers from across campus with BSL-3 training and resources for working with BSL-3 pathogens. The LIDR is administered under the direction of the Division of Research, Innovation and Impact. The goals of the BPC are to facilitate and support research by offering professional user training, scientific procedural oversight, and to advise on all matters related to the scientific program including facility compliance and safety. To achieve this goal, the BSL-3 Practices Core interfaces with all aspects of LIDR, including building and facility infrastructure, security, laboratory practices, decontamination, and, importantly, the BPC oversees the compliance of the BSL-3/select agent program as well as initial and ongoing training of its users. Towards these goals, the LIDR Biosafety Level 3 Practices Core oversees compliance for working with select agents, including the LIDR Personnel Suitability and Reliability Program (PSRP). For individuals cleared for entry into the LIDR, the BSL-3 Practices Core will provide a comprehensive initial and ongoing competency-based training program, and will be responsible for certifying the readiness of all individuals for entering BSL-3/ACL-3/ABSL-3 laboratories and associated support spaces. In addition, the BSL-3 Practices Core manages emergency response planning, as well as drills, exercises and after-action reports, investigations and corrective action plans for the BSL-3 program at LIDR. To maximize efficiencies and adoption of best practices, the BSL-3 Practices Core is committed to workforce development by offering continuing education and certifications for biocontainment professionals. Further, the BSL-3 Practices Core will work closely with Core 1 and Core 3 in this UC7 project to train professional staff in the biosafety, biocontainment, and the safe operations of aerosol- generating instrumentation. The BSL-3 Practices Core interacts closely with the Institutional Biosafety Committee, Principal Investigators, the LIDR Operations Committee, and the RBL-NBL network to develop and adopt best practice standard operating procedures and conduct risk assessments for all work associated with BSL-3 pathogens. The BSL-3 Practices Core plays a central role in the pandemic preparedness and response of the LIDR to facilitate its contributions to meeting the needs of emerging infectious diseases. Overall, the BSL- 3 Practices Core enables the work performed at LIDR, and assures that the BSL-3 Cores for the Facility Operations and Research Resources can carry out their objectives for high containment research without harming themselves, the environment or community.

项目摘要 核心2：生物安全3级实践 传染病研究实验室（LIDR）的生物安全3级实践核心（BPC） 包括三个主要组成部分：生物安全和应急计划，用户培训和能力监督， 并选择代理程序管理。BPC集成在LIDR计划中，定位为 为来自校园的LIDR研究人员提供BSL-3培训和使用BSL-3的资源 病原体LIDR是在研究，创新和影响司的指导下管理的。 BPC的目标是通过提供专业的用户培训、科学研究、 程序监督，并就与科学计划有关的所有事项提供建议，包括设施合规性 和安全性为了实现这一目标，BSL-3实践核心与LIDR的各个方面，包括建筑， 和设施基础设施，安全，实验室实践，去污，重要的是，BPC监督 BSL-3/选择代理程序的合规性以及对其用户的初始和持续培训。朝向 为了实现这些目标，LIDR生物安全3级实践核心监督与选定代理人合作的合规性， LIDR人员适用性和可靠性计划（PSRP）。对于获准进入 LIDR，BSL-3实践核心将提供全面的初始和持续的基于能力的培训 计划，并将负责证明所有个人进入BSL-3/ACL-3/ABSL-3的准备情况 实验室和相关的支持空间。此外，BSL-3实践核心管理紧急情况 应对计划，以及演习、演习和行动后报告、调查和纠正行动计划 LIDR的BSL-3项目为了最大限度地提高效率和采用最佳做法，BSL-3做法 核心致力于通过提供继续教育和认证， 生物防护专家此外，BSL-3实践核心将与核心1和核心3密切合作， UC 7项目，培训生物安全、生物防护和气溶胶安全操作方面的专业人员- 生成仪表。BSL-3实践核心与机构生物安全 委员会，主要研究者，LIDR运营委员会和RBL-NBL网络， 采用最佳做法标准作业程序，并对所有与 BSL-3病原体。BSL-3实践核心在大流行防范和应对中发挥着核心作用 （c）加强LIDR的作用，以促进其对满足新出现的传染病的需要作出贡献。总的来说，BSL- 3 Practices Core能够在LIDR进行工作，并确保设施的BSL-3 Core 操作和研究资源可以实现其高遏制研究的目标， 伤害自己、环境或社区。