BSL-3 Practices Core

BSL-3 实践核心

• 批准号: 10793829
• 负责人: JEFFREY Joseph ADAMOVICZ
• 金额: $ 76.81万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793829
• 关键词: 2019-nCoV; Address; Adopted; Adoption; Aerosols; Area; Attention; Authorization documentation; Basic Science; COVID-19; Certification; Communicable Diseases; Communities; Competence; Complement; Containment; Continuing Education; Core Facility; Decontamination; Diagnostic; Emergency Situation; Emergency response; Emerging Communicable Diseases; Environment; Equipment; Equipment and supply inventories; Exercise; Faculty; Faculty Recruitment; Failure; Family suidae; Goals; Grant; Human Resources; Individual; Infectious Diseases Research; Influenza; Infrastructure; International; Investigation; Investments; Laboratories; Location; Maintenance; Methodology; Mission; Missouri; Modernization; Mutant Strains Mice; National Institute of Allergy and Infectious Disease; Operations Research; Play; Positioning Attribute; Precision Health; Prevention strategy; Principal Investigator; Procedures; Productivity; Public Health; Public Health Schools; Rattus; Readiness; Reporting; Research; Research Personnel; Research Support; Resource Development; Resources; Risk Assessment; Role; Safety; Science; Security; Services; Standardization; Students; Teaching Hospitals; Testing; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vaccines; Variant; Vector-transmitted infectious disease; Work; Workforce Development; authority; base; biocontainment facility; biosafety level 3 facility; emerging pathogen; improved; innovation; insight; institutional biosafety committee; instrumentation; interest; medical schools; meetings; new technology; operation; pandemic preparedness; pandemic response; pathogen; priority pathogen; programs; recruit; research and development; research facility; skills

Project Summary Core 2: Biosafety Level 3 Practices The Biosafety Level 3 Practices Core (BPC) at the Laboratory of Infectious Disease Research (LIDR) includes three major components: Biosafety and emergency planning, user training and competency oversight, and select agent program management. The BPC is integrated within the LIDR program and is positioned to provide LIDR researchers from across campus with BSL-3 training and resources for working with BSL-3 pathogens. The LIDR is administered under the direction of the Division of Research, Innovation and Impact. The goals of the BPC are to facilitate and support research by offering professional user training, scientific procedural oversight, and to advise on all matters related to the scientific program including facility compliance and safety. To achieve this goal, the BSL-3 Practices Core interfaces with all aspects of LIDR, including building and facility infrastructure, security, laboratory practices, decontamination, and, importantly, the BPC oversees the compliance of the BSL-3/select agent program as well as initial and ongoing training of its users. Towards these goals, the LIDR Biosafety Level 3 Practices Core oversees compliance for working with select agents, including the LIDR Personnel Suitability and Reliability Program (PSRP). For individuals cleared for entry into the LIDR, the BSL-3 Practices Core will provide a comprehensive initial and ongoing competency-based training program, and will be responsible for certifying the readiness of all individuals for entering BSL-3/ACL-3/ABSL-3 laboratories and associated support spaces. In addition, the BSL-3 Practices Core manages emergency response planning, as well as drills, exercises and after-action reports, investigations and corrective action plans for the BSL-3 program at LIDR. To maximize efficiencies and adoption of best practices, the BSL-3 Practices Core is committed to workforce development by offering continuing education and certifications for biocontainment professionals. Further, the BSL-3 Practices Core will work closely with Core 1 and Core 3 in this UC7 project to train professional staff in the biosafety, biocontainment, and the safe operations of aerosol- generating instrumentation. The BSL-3 Practices Core interacts closely with the Institutional Biosafety Committee, Principal Investigators, the LIDR Operations Committee, and the RBL-NBL network to develop and adopt best practice standard operating procedures and conduct risk assessments for all work associated with BSL-3 pathogens. The BSL-3 Practices Core plays a central role in the pandemic preparedness and response of the LIDR to facilitate its contributions to meeting the needs of emerging infectious diseases. Overall, the BSL- 3 Practices Core enables the work performed at LIDR, and assures that the BSL-3 Cores for the Facility Operations and Research Resources can carry out their objectives for high containment research without harming themselves, the environment or community.

项目概要 核心 2：生物安全 3 级实践 传染病研究实验室 (LIDR) 的生物安全 3 级实践核心 (BPC) 包括三个主要组成部分：生物安全和应急计划、用户培训和能力监督、 并选择代理程序管理。 BPC 集成在 LIDR 计划中，旨在 为整个校园的 LIDR 研究人员提供 BSL-3 培训和使用 BSL-3 的资源 病原体。 LIDR 在研究、创新和影响部门的指导下管理。 BPC 的目标是通过提供专业的用户培训、科学的方法来促进和支持研究。 程序监督，并就与科学计划相关的所有事项（包括设施合规性）提供建议 和安全。为了实现这一目标，BSL-3 实践核心与 LIDR 的各个方面相结合，包括构建 和设施基础设施、安全、实验室实践、净化，以及重要的是 BPC 的监督 BSL-3/精选代理程序的合规性及其用户的初始和持续培训。向 这些目标，LIDR 生物安全 3 级实践核心监督与选定代理商合作的合规性， 包括 LIDR 人员适宜性和可靠性计划 (PSRP)。对于获准入境的个人 LIDR（BSL-3 实践核心）将提供全面的初始和持续的基于能力的培训 计划，并将负责证明所有个人是否已准备好进入 BSL-3/ACL-3/ABSL-3 实验室和相关支持空间。此外，BSL-3 实践核心管理紧急情况 响应计划以及演习、演习和行动后报告、调查和纠正行动计划 LIDR 的 BSL-3 项目。为了最大限度地提高效率并采用最佳实践，BSL-3 实践 Core 致力于通过提供继续教育和认证来促进劳动力发展 生物防护专业人员。此外，BSL-3 实践核心将在这方面与核心 1 和核心 3 密切合作。 UC7 项目旨在培训生物安全、生物防护和气溶胶安全操作方面的专业人员 生成仪器仪表。 BSL-3 实践核心与机构生物安全密切互动 委员会、首席研究员、LIDR 运营委员会和 RBL-NBL 网络来开发和 采用最佳实践标准操作程序并对与相关的所有工作进行风险评估 BSL-3 病原体。 BSL-3 实践核心在大流行准备和应对中发挥着核心作用 LIDR 的职责，以促进其为满足新出现的传染病的需求做出贡献。总体而言，BSL- 3 个实践核心使 LIDR 能够开展工作，并确保该设施的 BSL-3 核心 运营和研究资源可以实现其高遏制研究的目标，而无需 伤害自己、环境或社区。