Biocontainment Research Support Service(s) Core

生物防护研究支持服务核心

• 批准号: 10793952
• 负责人: Dominique M. Missiakas
• 金额: $ 78.33万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793952
• 关键词: Animal Model; Antibiotic Resistance; Articulation; Bacillus anthracis; Biochemical; Biological Assay; Biological Products; Cells; Charge; Chicago; Collaborations; Communities; Consultations; Containment; Data; Development; Diagnostic; Drug Screening; Emergency response; Emerging Communicable Diseases; Ensure; Environment; Equipment; Event; Genetic; Goals; Growth; Guidelines; Health; Immune response; Immunization; In Vitro; Infection; Infectious Diseases Research; Infrastructure; Institution; Instruction; Knowledge; Laboratories; Lead; Learning; Measures; Microbe; Mission; Mycobacterium tuberculosis; Names; Phenotype; Process; Protocols documentation; RNA Viruses; Reporting; Research; Research Personnel; Research Support; Research Training; Resistance profile; Rickettsia; Secure; Services; Sister; Specimen; Standardization; Supervision; Technology; Testing; Therapeutic; Training; Universities; Yersinia pestis; biocontainment facility; biodefense; biosecurity; design; experience; high risk; high throughput screening; in vivo; instrument; microbial; new pandemic; pathogen; recruit; response; skills; small molecule inhibitor; vaccine development; web page; web portal

PROJECT ABSTRACT (Core 3/C3ResearchSupport@HTRL) The Howard T. Ricketts Laboratory (HTRL) takes pride in its mission to provide a safe and secure environment for cutting-edge Biodefense and Emerging Infectious Diseases research, under the support and supervision of professionals with over 20 years of experience and under the umbrella of Core 3 (C3ResearchSupport@HTRL). The three aims of C3ResearchSupport@HTRL are to: (1) offer professional research services for the isolation and characterization of a wide range of RG3/Select Agent pathogens (sub- core C3Microbiology@HTRL); (2) offer professional research services in animal modelling of infection (sub- core C3AnimalModels@HTRLB); (3) offer hands-on A/BSL3 training to Core 3 Users (sub-core C3Training@HTRL). All these services will be advertised on the HTRL web page and will be rendered following free consultation. C3ResearchSupport@HTRL draws on the extensive expertise of Drs. Ahmed and Khader (Mycobacterium tuberculosis), Glenn Randall (RNA viruses) and Dominique Missiakas (Bacillus anthracis, Yersinia pestis, Rickettsia sp.) at the University of Chicago. C3ResearchSupport@HTRL will operate in collaboration with the RBL network, drawing on the expertise of 11 sister laboratories to provide broad research support, implement contingency plans, and ensure a prompt response in the event of imminent health threats to the nation. Briefly, C3Microbiology@HTRL will provide high-end technologies and expertise toward the isolation and characterization of RG3 pathogens (biochemical, genetic, phenotypic characterizations including antibiotic resistance profiles), the standardization of growth assays to test small molecule inhibitors, the study of pathogen interactions with host cells. C3AnimalModels@HTRL will provide standardized, high quality small animal models of infection for the development of countermeasures and for the study of host responses. C3Training@HTRL will offer Users of Core 3 an opportunity to receive basic instructions on biosafety, biosecurity, regulatory processes for the handling of high-risk pathogens, SOPs, and safe laboratory practice in BSL3. C3ResearchSupport@HTRL aims to provide pristine expertise to support research in response to new pandemics or biodefense threats on our nation or world-wide.

项目摘要（核心3/C3ResearchSupport@HTRL）