Biocontainment Research Support Service(s) Core

项目摘要（核心3/C3ResearchSupport@HTRL） 霍华德·T.里基茨实验室（HTRL）以其提供安全可靠的环境的使命而自豪 前沿生物防御和新兴传染病研究，在支持和监督下， 拥有超过20年经验的专业人士，并在核心3的保护伞下 （C3ResearchSupport@HTRL）. C3ResearchSupport@HTRL的三个目标是：（1）提供专业的 研究服务，用于分离和表征多种RG 3/选择病原体（子 核心C3Microbiology@HTRL）;（2）提供专业的感染动物模型研究服务（亚 核心C3AnimalModels@HTRLB）;（3）向核心3用户（子核心）提供A/BSL 3实践培训 C3Training@HTRL）。所有这些服务都将在HTRL网页上进行广告宣传， 经过免费咨询。C3 ResearchSupport @ HTRL借鉴了Ahmed博士的广泛专业知识， Khader（结核分枝杆菌）、Glenn Randall（RNA病毒）和Dominique Missiakas（芽孢杆菌 炭疽、鼠疫耶尔森氏菌、立克次氏体属（Rickettsia sp.）在芝加哥大学。C3ResearchSupport@HTRL将 与RBL网络合作，利用11个姐妹实验室的专业知识， 广泛的研究支持，实施应急计划，并确保在紧急情况下迅速作出反应 对国家的健康威胁。简而言之，C3Microbiology@HTRL将提供高端技术和专业知识， 对RG 3病原体的分离和表征（生化、遗传、表型 包括抗生素耐药性概况），生长测定的标准化，以测试小 分子抑制剂，病原体与宿主细胞相互作用的研究。C3AnimalModels@HTRL将提供 规范化、高质量的小动物感染模型的研制对策， 研究宿主的反应。C3Training@HTRL将为Core 3的用户提供获得基本 关于生物安全、生物安保、处理高风险病原体的监管程序、SOP的说明，以及 BSL 3中的安全实验室实践。C3ResearchSupport@HTRL旨在提供原始的专业知识， 研究应对新的流行病或生物防御威胁对我们的国家或世界范围内。

PROJECT ABSTRACT (Core 3/C3ResearchSupport@HTRL) The Howard T. Ricketts Laboratory (HTRL) takes pride in its mission to provide a safe and secure environment for cutting-edge Biodefense and Emerging Infectious Diseases research, under the support and supervision of professionals with over 20 years of experience and under the umbrella of Core 3 (C3ResearchSupport@HTRL). The three aims of C3ResearchSupport@HTRL are to: (1) offer professional research services for the isolation and characterization of a wide range of RG3/Select Agent pathogens (sub- core C3Microbiology@HTRL); (2) offer professional research services in animal modelling of infection (sub- core C3AnimalModels@HTRLB); (3) offer hands-on A/BSL3 training to Core 3 Users (sub-core C3Training@HTRL). All these services will be advertised on the HTRL web page and will be rendered following free consultation. C3ResearchSupport@HTRL draws on the extensive expertise of Drs. Ahmed and Khader (Mycobacterium tuberculosis), Glenn Randall (RNA viruses) and Dominique Missiakas (Bacillus anthracis, Yersinia pestis, Rickettsia sp.) at the University of Chicago. C3ResearchSupport@HTRL will operate in collaboration with the RBL network, drawing on the expertise of 11 sister laboratories to provide broad research support, implement contingency plans, and ensure a prompt response in the event of imminent health threats to the nation. Briefly, C3Microbiology@HTRL will provide high-end technologies and expertise toward the isolation and characterization of RG3 pathogens (biochemical, genetic, phenotypic characterizations including antibiotic resistance profiles), the standardization of growth assays to test small molecule inhibitors, the study of pathogen interactions with host cells. C3AnimalModels@HTRL will provide standardized, high quality small animal models of infection for the development of countermeasures and for the study of host responses. C3Training@HTRL will offer Users of Core 3 an opportunity to receive basic instructions on biosafety, biosecurity, regulatory processes for the handling of high-risk pathogens, SOPs, and safe laboratory practice in BSL3. C3ResearchSupport@HTRL aims to provide pristine expertise to support research in response to new pandemics or biodefense threats on our nation or world-wide.