Biocontainment Research Support Service(s) Core

项目摘要(Core 3/C3ResearchSupport@HTRL) 霍华德·T·里基茨实验室(HTRL)为其提供安全可靠的环境的使命而感到自豪 用于尖端生物防御和新发传染病研究，在 拥有超过20年经验并隶属于Core 3的专业人士 (C3ResearchSupport@HTRL)。C3ResearchSupport@HTRL的三个目标是：(1)提供专业的 为广泛的RG3/选择试剂病原体的分离和表征提供的研究服务(亚 核心C3微生物学@HTRL)；(2)在感染的动物模型方面提供专业研究服务(分 核心C3AnimalModels@HTRLB)；(3)为核心3用户(分核心)提供实践A/BSL3培训 C3Training@HTRL)。所有这些服务都将在HTRL网页上做广告，并将提供 在免费咨询之后。C3ResearchSupport@HTRL利用了Ahmed博士和 Khader(结核分枝杆菌)、Glenn Randall(RNA病毒)和Dominique Missiakas(芽孢杆菌) (炭疽菌、鼠疫耶尔森氏菌、立克次体)在芝加哥大学。C3ResearchSupport@HTRL将 与RBL网络合作，利用11个姊妹实验室的专业知识提供 广泛的研究支持，实施应急计划，确保在迫在眉睫的情况下迅速做出反应 对国家健康的威胁。简而言之，C3Micro@HTRL将提供高端技术和专业知识 Rg3病原菌(生化、遗传、表型)的分离与鉴定 特征包括抗生素耐药性曲线)，标准化的生长分析，以测试 分子抑制物，研究病原体与宿主细胞的相互作用。C3AnimalModels@HTRL将提供 标准化、高质量的小动物感染模型的发展对策和 研究寄主反应。C3Training@HTRL将为Core 3的用户提供获得基本服务的机会 关于生物安全、生物安保、处理高风险病原体的监管流程、SOP和 BSL3中的安全实验室实践。C3ResearchSupport@HTRL旨在提供原始的专业知识以支持 应对我国或全世界新的流行病或生物防御威胁的研究。

PROJECT ABSTRACT (Core 3/C3ResearchSupport@HTRL) The Howard T. Ricketts Laboratory (HTRL) takes pride in its mission to provide a safe and secure environment for cutting-edge Biodefense and Emerging Infectious Diseases research, under the support and supervision of professionals with over 20 years of experience and under the umbrella of Core 3 (C3ResearchSupport@HTRL). The three aims of C3ResearchSupport@HTRL are to: (1) offer professional research services for the isolation and characterization of a wide range of RG3/Select Agent pathogens (sub- core C3Microbiology@HTRL); (2) offer professional research services in animal modelling of infection (sub- core C3AnimalModels@HTRLB); (3) offer hands-on A/BSL3 training to Core 3 Users (sub-core C3Training@HTRL). All these services will be advertised on the HTRL web page and will be rendered following free consultation. C3ResearchSupport@HTRL draws on the extensive expertise of Drs. Ahmed and Khader (Mycobacterium tuberculosis), Glenn Randall (RNA viruses) and Dominique Missiakas (Bacillus anthracis, Yersinia pestis, Rickettsia sp.) at the University of Chicago. C3ResearchSupport@HTRL will operate in collaboration with the RBL network, drawing on the expertise of 11 sister laboratories to provide broad research support, implement contingency plans, and ensure a prompt response in the event of imminent health threats to the nation. Briefly, C3Microbiology@HTRL will provide high-end technologies and expertise toward the isolation and characterization of RG3 pathogens (biochemical, genetic, phenotypic characterizations including antibiotic resistance profiles), the standardization of growth assays to test small molecule inhibitors, the study of pathogen interactions with host cells. C3AnimalModels@HTRL will provide standardized, high quality small animal models of infection for the development of countermeasures and for the study of host responses. C3Training@HTRL will offer Users of Core 3 an opportunity to receive basic instructions on biosafety, biosecurity, regulatory processes for the handling of high-risk pathogens, SOPs, and safe laboratory practice in BSL3. C3ResearchSupport@HTRL aims to provide pristine expertise to support research in response to new pandemics or biodefense threats on our nation or world-wide.