Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory

密苏里大学区域生物防护实验室 NIH/NIAID 高优先级病原体研究的资源和劳动力发展

• 批准号: 10793827
• 负责人: Wendy L Picking
• 金额: $ 259.55万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793827
• 关键词: 2019-nCoV; Acceleration; Address; Adoption; Animal Housing; Animal Model; Appointment; Arboviruses; Area; Award; COVID-19; COVID-19 pandemic; Communicable Diseases; Communities; Core Facility; Decontamination; Dedications; Development; Disease Outbreaks; Disinfectants; Emerging Communicable Diseases; Equipment; Evaluation; Event; Evolution; Faculty; Funding; Future; Goals; Grant; Growth; Human; Human Resources; Image; Immunology; Infection; Infectious Diseases Research; Influenza; Infrastructure; Institution; Investments; Knowledge; Laboratories; Leadership; Maintenance; Microbiology; Midwestern United States; Mission; Missouri; Modernization; Names; National Institute of Allergy and Infectious Disease; National Security; Output; Phase; Preparation; Prevention approach; Productivity; Public Health; Regulation; Research; Research Personnel; Research Support; Resource Development; Resources; Role; Safety; Scientist; Secure; Security; Senior Scientist; Services; System; Technology; Training; United States National Institutes of Health; Universities; Virus; Work; Workforce Development; animal model development; biodefense; combat; coronavirus disease; experience; improved; instrumentation; laboratory experiment; medical countermeasure; member; microbial; new outbreak; new technology; next generation; novel; novel strategies; operation; pandemic disease; pandemic potential; pandemic preparedness; pathogen; prevent; priority pathogen; programs; public health relevance; recruit; research and development; response; synergism; transmission process; vaccine platform; vector-borne

Overall Project Summary Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory The University of Missouri Regional Biocontainment Laboratory (RBL) was commissioned in 2009 as an $18M, 12,377 NSF BSL-3/ABSL-3 facility. During its thirteen years of operation, the RBL, since named the MU Laboratory for Infectious Disease Research (LIDR) has been a centerpiece of the broader infectious disease research community at the University of Missouri, receiving strong institutional commitment in the recruitment and sustainment of world-class faculty for management of the RBL/LIDR and for conducting research on high priority pathogens. The LIDR operates shared research resources, including state-of-the-art equipment and professional services in microbiology, aerobiology, immunology, and animal model core facilities that serve the needs of researchers on campus and in the broader regional and national communities. The faculty and professional staff of the LIDR are part of the NIH/NIAID RBL-NBL network, with collaborative interactions that facilitate sharing of best practices and knowledge, providing synergy in achieving our collective biodefense and emerging infectious disease research agenda. During the COVID pandemic, the MU LIDR, along with its RBL and NBL partners, led the response to the pandemic and are committed to strengthening pandemic preparedness of the nation, by providing BSL-3/ABSL-3 training, professional staff, and research services that allow for rapid responses in all areas, including development of animal models and the evaluation of numerous treatments, disinfectants, and vaccine platforms to combat the pandemic. The long-term goal of the present application is to sustain a leading effort for development of novel medical countermeasures for combating the ever present and changing threats of emerging and re-emerging infectious diseases, while training an outstanding cadre of next generation scientists and professionals in biocontainment. The goals of the proposed cores in Facility Management, Maintenance and Operations, BSL3 Practices, and Biocontainment Research Support Services are to educate and train the next generation of scientists and biocontainment professionals in biodefense and emerging infectious diseases, and to facilitate and enhance the development of novel approaches for prevention and treatment of infections caused by high consequence pathogens whose natural or deliberate transmission pose a threat to public health and national security. Towards these goals, the proposed Cores will work within the broader infectious disease community at MU and the NIH/NIAID RBL-NBL network for enhancement of research productivity and discovery, and continued sharing of information and best practices in order to meet the changing priorities and needs of NIH/NIAID for biodefense and emerging infectious diseases.

总体项目摘要 资源和劳动力发展的研究NIH/NIAID高优先级病原体在大学 密苏里州地区生物防护实验室 密苏里州大学区域生物遏制实验室（RBL）于2009年投入1800万美元， 12，377 NSF BSL-3/ABSL-3设施。在其十三年的运作中，RBL自命名为MU以来， 传染病研究实验室（LIDR）一直是更广泛的传染病研究的中心。 研究社区在密苏里州的大学，在招聘中获得强有力的机构承诺 和维持世界一流的教师的RBL/LIDR的管理和进行研究的高 优先病原体。LIDR运营共享的研究资源，包括最先进的设备和 微生物学、空气生物学、免疫学和动物模型核心设施的专业服务， 研究人员在校园和更广泛的区域和国家社区的需求。教职 LIDR的专业人员是NIH/NIAID RBL-NBL网络的一部分，他们之间的协作互动 促进分享最佳做法和知识，为实现我们的集体生物防御提供协同作用， 新兴传染病研究议程。在COVID大流行期间，MU LIDR连同其RBL沿着 和NBL合作伙伴，领导了对大流行的反应，并致力于加强大流行 国家的准备，通过提供BSL-3/ABSL-3培训，专业人员和研究服务， 允许在所有领域做出快速反应，包括开发动物模型和评估许多 治疗、消毒剂和疫苗平台，以抗击大流行。当前的长远目标 应用是为了维持开发新的医学对策的领先努力，以对抗 新出现和重新出现的传染病的威胁不断存在和变化，同时培训和 下一代科学家和生物防护专业人员的杰出骨干。拟议的目标 设施管理、维护和运营、BSL 3实践和生物防护研究的核心 支持服务是教育和培训下一代科学家和生物防护专业人员， 生物防御和新出现的传染病，并促进和加强新的 用于预防和治疗由高后果病原体引起的感染的方法 或故意传播对公共卫生和国家安全构成威胁。为了实现这些目标， 核心将在MU和NIH/NIAID RBL-NBL网络的更广泛的传染病社区内工作， 提高研究生产力和发现，并继续分享信息和最佳做法， 以满足NIH/NIAID在生物防御和新发传染病方面不断变化的优先事项和需求。