Facility Management, Maintenance and Operation Core

设施管理、维护和运营核心

• 批准号: 10793953
• 负责人: ELIZABETH ANN FITZPATRICK
• 金额: $ 74.5万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793953
• 关键词: Air Purifying Respirators; Animals; Basic Science; Carbon Dioxide; Certification; Client; Containment; Contract Services; Contracts; Core Facility; Decontamination; Development; Engineering; Equipment; Failure; Goals; Health Sciences; Incubators; Individual; Infectious Agent; Infrastructure; Interruption; Laboratories; Life Expectancy; Longevity; Maintenance; Mechanics; Medical; Mission; Monitor; Mus; Occupational Exposure; Outcome; Periodicals; Procedures; Process; Productivity; Regulation; Research; Research Personnel; Research Support; Services; System; Tennessee; Translational Research; Universities; Validation; biodefense; end of life; improved; laboratory facility; operation; prevent; programs; promote resilience

The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) provides a vast array of services that support the discovery and development of countermeasures for biodefense and emerging infectious agents with unmet medical needs. Central to this mission is the support the RBL provides for basic and translational research that require biosafety level 3 (BSL-3) or animal BSL-3 (ABSL-3) containment. The long-term goal for the Facilities Management Maintenance and Operations Core (Facility core) is to provide the appropriate management team, staff, engineering controls and equipment necessary to support those research programs requiring ABSL-3 and BSL-3 containment without interruption and in compliance with federal regulations. The Facilities core will integrate oversight for (1) maintenance of the mechanical and vivarium infrastructure necessary for daily operation of the BSL-3 and ABLS-3 labs, (2) annual certification, preventative maintenance and monitoring of critical building systems (3) decontamination of equipment and materials leaving the facility, and (4) maintenance of basic lab scientific and biosafety equipment needed by RBL users such as Powered Air Purifying Respirators (PAPRs), freezers, CO2 incubators, etc. This will be achieved through the following aims and goals. Aim 1. Maintenance and operation of the mechanical infrastructure to support BSL-3 and ABLS3 labs including the replacement of critical components of the mechanical infrastructure that are currently beyond their normal life expectancy and the preventative maintenance contracts needed for periodic validation and certification of the labs of the building systems. Aim 2. Maintenance of the vivarium infrastructure to support research in ABSL-3 containment. This includes replacement of mouse caging systems that are at end-of-life and annual preventative maintenance and certification processes. Aim 3. Maintenance and certification of BSL-3 lab scientific and biosafety equipment used by researchers working in the BS-3 and ABSl-3 containment. This includes replacement of biosafety cabinets that have reached the end-of-life as well as basic scientific equipment that is heavily used by our researchers. The outcomes will be to extend the operating lifespan for the RBL, protect RBL staff and users from occupational exposures due to mechanical failures, prevent extended shutdown of the RBL due to mechanical failures, and improve efficiency and research productivity by removing bottlenecks and keeping the BSL-3 and ABSL-3 labs operating at full capacity.

田纳西大学健康科学中心 (UTHSC) 区域生物防护 实验室 (RBL) 提供广泛的服务来支持发现和开发 生物防御和新出现的传染源未满足医疗需求的对策。 这一使命的核心是 RBL 为基础研究和转化研究提供的支持， 需要生物安全等级 3 (BSL-3) 或动物 BSL-3 (ABSL-3) 遏制。长期目标为 设施管理维护和运营核心（设施核心）是提供 支持所需的适当管理团队、员工、工程控制和设备 那些需要不间断地进行ABSL-3和BSL-3遏制的研究项目 遵守联邦法规。设施核心将整合以下方面的监督：(1) 维护日常运营所需的机械和饲养场基础设施 BSL-3 和 ABLS-3 实验室，(2) 年度认证、预防性维护和监控 关键建筑系统 (3) 对离开设施的设备和材料进行净化，以及 (4) RBL用户所需的基本实验室科学和生物安全设备的维护，例如 动力空气净化呼吸器 (PAPR)、冷冻柜、CO2 培养箱等。这将实现 通过以下目的和目标。目标1.机械的维护和操作 支持 BSL-3 和 ABLS3 实验室的基础设施，包括更换关键组件 目前超出其正常预期寿命的机械基础设施和 定期验证和认证实验室所需的预防性维护合同 建筑系统。目标 2. 维护动物饲养场基础设施以支持研究 ABSL-3 收容。这包括更换已报废的小鼠笼具系统 以及年度预防性维护和认证流程。目标 3. 维护和 从事研究工作的研究人员使用的 BSL-3 实验室科学和生物安全设备的认证 BS-3 和 ABSl-3 遏制。这包括更换已达到标准的生物安全柜 我们的研究人员大量使用的生命终结以及基本科学设备。这 结果将是延长 RBL 的使用寿命，保护 RBL 员工和用户免受 由于机械故障导致的职业暴露，防止 RBL 由于机械故障而长时间关闭 机械故障，并通过消除瓶颈提高效率和研究生产力 并保持 BSL-3 和 ABSL-3 实验室满负荷运行。