Facility Management, Maintenance and Operation Core

设施管理、维护和运营核心

• 批准号: 10793953
• 负责人: ELIZABETH ANN FITZPATRICK
• 金额: $ 74.5万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793953
• 关键词: Air Purifying Respirators; Animals; Basic Science; Carbon Dioxide; Certification; Client; Containment; Contract Services; Contracts; Core Facility; Decontamination; Development; Engineering; Equipment; Failure; Goals; Health Sciences; Incubators; Individual; Infectious Agent; Infrastructure; Interruption; Laboratories; Life Expectancy; Longevity; Maintenance; Mechanics; Medical; Mission; Monitor; Mus; Occupational Exposure; Outcome; Periodicals; Procedures; Process; Productivity; Regulation; Research; Research Personnel; Research Support; Services; System; Tennessee; Translational Research; Universities; Validation; biodefense; end of life; improved; laboratory facility; operation; prevent; programs; promote resilience

The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) provides a vast array of services that support the discovery and development of countermeasures for biodefense and emerging infectious agents with unmet medical needs. Central to this mission is the support the RBL provides for basic and translational research that require biosafety level 3 (BSL-3) or animal BSL-3 (ABSL-3) containment. The long-term goal for the Facilities Management Maintenance and Operations Core (Facility core) is to provide the appropriate management team, staff, engineering controls and equipment necessary to support those research programs requiring ABSL-3 and BSL-3 containment without interruption and in compliance with federal regulations. The Facilities core will integrate oversight for (1) maintenance of the mechanical and vivarium infrastructure necessary for daily operation of the BSL-3 and ABLS-3 labs, (2) annual certification, preventative maintenance and monitoring of critical building systems (3) decontamination of equipment and materials leaving the facility, and (4) maintenance of basic lab scientific and biosafety equipment needed by RBL users such as Powered Air Purifying Respirators (PAPRs), freezers, CO2 incubators, etc. This will be achieved through the following aims and goals. Aim 1. Maintenance and operation of the mechanical infrastructure to support BSL-3 and ABLS3 labs including the replacement of critical components of the mechanical infrastructure that are currently beyond their normal life expectancy and the preventative maintenance contracts needed for periodic validation and certification of the labs of the building systems. Aim 2. Maintenance of the vivarium infrastructure to support research in ABSL-3 containment. This includes replacement of mouse caging systems that are at end-of-life and annual preventative maintenance and certification processes. Aim 3. Maintenance and certification of BSL-3 lab scientific and biosafety equipment used by researchers working in the BS-3 and ABSl-3 containment. This includes replacement of biosafety cabinets that have reached the end-of-life as well as basic scientific equipment that is heavily used by our researchers. The outcomes will be to extend the operating lifespan for the RBL, protect RBL staff and users from occupational exposures due to mechanical failures, prevent extended shutdown of the RBL due to mechanical failures, and improve efficiency and research productivity by removing bottlenecks and keeping the BSL-3 and ABSL-3 labs operating at full capacity.

田纳西大学健康科学中心（UTHSC）区域生物防护 实验室（RBL）提供了大量的服务，支持发现和开发 应对生物防御和医疗需求未得到满足的新出现的传染性病原体的对策。 这一使命的核心是RBL为基础和转化研究提供的支持， 要求生物安全3级（BSL-3）或动物BSL-3（ABSL-3）的遏制。年远景目标 设施管理、维护和运营核心（设施核心）将提供 适当的管理团队、工作人员、工程控制和必要的设备， 这些研究计划需要ABSL-3和BSL-3遏制不中断， 符合联邦法规。设施核心将整合以下方面的监督： 维持日常运作所需的机械和饲养场基础设施， BSL-3和ABLS-3实验室，（2）年度认证，预防性维护和监测 关键建筑系统（3）对离开设施的设备和材料进行去污，以及 (4)维护RBL用户所需的基本实验室科学和生物安全设备， 电动空气净化呼吸器（PAPR）、冷冻机、二氧化碳培养箱等。 通过以下目的和目标。目标1.机械设备的维护和操作 支持BSL-3和ABLS 3实验室的基础设施，包括更换关键组件 机械基础设施目前已超过其正常寿命， 实验室定期验证和认证所需的预防性维护合同 建筑系统。目标二。维持动物园基础设施，以支持 ABSL-3级隔离这包括更换寿命结束的小鼠笼系统 以及年度预防性维护和认证流程。目标3。维护和 BSL-3实验室科学和生物安全设备的认证， BS-3和ABS 1 -3安全壳。这包括更换已达到 以及我们的研究人员大量使用的基本科学设备。的 结果将是延长RBL的运行寿命，保护RBL工作人员和用户免受 由于机械故障导致的职业暴露，防止RBL因 机械故障，并通过消除瓶颈来提高效率和研究生产力 并保持BSL-3和ABSL-3实验室满负荷运转。