Facility Management, Maintenance and Operation Core

田纳西大学健康科学中心区域生物控制 实验室(RBL)提供大量支持发现和开发的服务 针对未得到满足的医疗需求的生物防御和新出现的传染病病原体的对策。 这项任务的核心是RBL为基础和翻译研究提供的支持，这些研究 要求生物安全等级3(BSL-3)或动物BSL-3(ABSL-3)容器。的长期目标是 设施管理维护和运营核心(设施核心)将提供 支持所需的适当管理团队、人员、工程控制和设备 这些研究计划需要ABSL-3和BSL-3遏制不间断和在 遵守联邦法规。设施核心将整合对(1)的监督 维护日常运作所需的机械和间隔室基础设施 BSL-3和ABLS-3实验室，(2)年度认证、预防性维护和监测 关键建筑系统(3)对离开设施的设备和材料进行去污，以及 (4)维护RBL用户所需的基本实验室科学和生物安全设备，如 电动空气净化呼吸器(PAPR)、冰柜、二氧化碳培养箱等。这将实现 通过以下目的和目标。目标1.机械设备的维护和操作 支持BSL-3和ABLS3实验室的基础设施，包括更换关键组件 机械基础设施目前超出其正常预期寿命，以及 定期验证和认证实验室所需的预防性维护合同 建筑系统。目标2.维护间隔室基础设施，以支持研究 ABSL-3安全壳。这包括更换已报废的鼠标笼养系统 以及年度预防性维护和认证流程。目标3.维护和 工作人员使用的BSL-3实验室科学和生物安全设备的认证 BS-3和ABSL-3围堵。这包括更换已经到达的生物安全柜 我们的研究人员大量使用的临终设备以及基本的科学设备。这个 结果将是延长RBL的运行寿命，保护RBL工作人员和用户免受 机械故障导致的职业暴露，防止RBL因 通过消除瓶颈来提高效率和研究生产率 并保持BSL-3和ABSL-3实验室满负荷运行。

The University of Tennessee Health Science Center (UTHSC) Regional Biocontainment Laboratory (RBL) provides a vast array of services that support the discovery and development of countermeasures for biodefense and emerging infectious agents with unmet medical needs. Central to this mission is the support the RBL provides for basic and translational research that require biosafety level 3 (BSL-3) or animal BSL-3 (ABSL-3) containment. The long-term goal for the Facilities Management Maintenance and Operations Core (Facility core) is to provide the appropriate management team, staff, engineering controls and equipment necessary to support those research programs requiring ABSL-3 and BSL-3 containment without interruption and in compliance with federal regulations. The Facilities core will integrate oversight for (1) maintenance of the mechanical and vivarium infrastructure necessary for daily operation of the BSL-3 and ABLS-3 labs, (2) annual certification, preventative maintenance and monitoring of critical building systems (3) decontamination of equipment and materials leaving the facility, and (4) maintenance of basic lab scientific and biosafety equipment needed by RBL users such as Powered Air Purifying Respirators (PAPRs), freezers, CO2 incubators, etc. This will be achieved through the following aims and goals. Aim 1. Maintenance and operation of the mechanical infrastructure to support BSL-3 and ABLS3 labs including the replacement of critical components of the mechanical infrastructure that are currently beyond their normal life expectancy and the preventative maintenance contracts needed for periodic validation and certification of the labs of the building systems. Aim 2. Maintenance of the vivarium infrastructure to support research in ABSL-3 containment. This includes replacement of mouse caging systems that are at end-of-life and annual preventative maintenance and certification processes. Aim 3. Maintenance and certification of BSL-3 lab scientific and biosafety equipment used by researchers working in the BS-3 and ABSl-3 containment. This includes replacement of biosafety cabinets that have reached the end-of-life as well as basic scientific equipment that is heavily used by our researchers. The outcomes will be to extend the operating lifespan for the RBL, protect RBL staff and users from occupational exposures due to mechanical failures, prevent extended shutdown of the RBL due to mechanical failures, and improve efficiency and research productivity by removing bottlenecks and keeping the BSL-3 and ABSL-3 labs operating at full capacity.