ALCOHOL AND AIDS-A MURINE MODEL

获得性免疫缺陷综合征(AIDS)已成为一个关键 美国的健康问题。感染致病 慢病毒-艾滋病毒-导致进行性和衰弱的 免疫抑制。因为从初次感染到 艾滋病毒和艾滋病的发病在个人之间有很大的差异，它是 重要的是要确定辅助因素的作用，如酗酒 疾病的发展。据报道，乙醇 消费对寄主的能力有不利的影响 产生体液和细胞免疫反应。长期酗酒是 在吸毒者中很常见，这是艾滋病的高危人群，以及酒精 相关的免疫抑制可能与HIV诱导的免疫协同作用 免疫抑制以缩短疾病的发病时间和/或增加 疾病的严重程度。我们将使用逆转录病毒诱导的小鼠获得 免疫缺陷综合征(MAIDS)模型急性发作疗效判定 与长期饮酒有关的HIV相关疾病的发展 免疫抑制。实验的设计是为了确定 乙醇对女佣病毒混合感染后复制的影响 动物。我们还将研究乙醇对 由病毒感染激活的T和B细胞以及 负责淋巴增殖的T和B细胞亚群。 最后，我们将研究逆转录病毒诱导的机制。 免疫抑制及酒精摄入对小鼠免疫功能的影响 这些机制。

The acquired immunodeficiency syndrome (AIDS) has become a critical health problem in the United States. Infection with the disease-causing lentivirus-HIV-results in a progressive and debilitating immunosuppression. Because of the period between initial infection with HIV and onset of AIDS is quite variable among individuals, it is important to determine the role of co-factors, such as alcohol abuse, in the development of the disease. It has been reported that ethanol consumption has a detrimental effect on the ability of the host to generate humoral and cellular immune responses. Chronic alcohol abuse is common among drug users, a group at high risk for AIDS, and ethanol associated immunosuppression may act synergistically with HIV-induced immunosuppression to shorten the onset of disease and/or increase the severity of disease. We will use the retroviral-induce murine acquired immunodeficiency syndrome (MAIDS) model to determine the effect of acute and chronic ethanol consumption on the development of HIV-associated immunosuppression. Experiments are designed to determine the effect of ethanol on the replication of the MAIDS virus mixture in infected animals. We will also examine the effect of ethanol on the percentage of T and B cells which are activated by virus infection as well as the subsets of T and B cells responsible for the lymphoproliferation. Finally we will examine the mechanisms of retroviral-induce immunosuppression and the effect of ethanol consumption on generation of these mechanisms.