Antiviral & Antimicrobial Countermeasures Discovery and Development Core

项目摘要 拟议的抗病毒和抗微生物对策发现和开发核心（本文 缩写为 A2CD2C）将促进针对发现和/或开发的生物医学研究 人类生物安全3级（BSL-3）病原体的预防性或治疗性处理的对策或 BSL-2 病原体需要选择药剂控制。 A2CD2C 将使用最先进的技术来实现这项研究 小分子设备 (1) 筛选，(2) 成像，(3) 液相色谱-质谱分析 (LCMS/MS) 服务和 (4) 组织学。核心将安置在 UTHSC 区域生物防护内 BSL-3 空间的实验室 (RBL)。 A2CD2C 的重要性在于它提供了一种高效、集成、 综合平台，将促进从最初发现阶段到临床前的研究 BSL-3 收容区内的开发。 A2CD2C 在 RBL 网络中是独一无二的，因为它专注于提供 对 BSL-3 中受感染、经过处理的动物组织进行 LC-MS 研究，以提供急需的感染部位信息 治疗剂暴露在感染部位，从而提供重要的药效学信息 临床前评估所需。 A2CD2C 的主要使命是维持、改进和扩展我们在药物领域的 RBL 支持服务 发现和开发，重点关注药物药效学，即药物的使用方式和用量 暴露会影响病原体的存活。我们在此提出三个要实现的目标： 目标 1. 维持 药物发现和开发方面的 A2CD2C 支持服务；目标 2. 改善 A2CD2C 支持服务 药物发现和开发；目标 3. 扩大药物成像中的 A2CD2C 支持服务 发现和发展。

PROJECT ABSTRACT The proposed Antiviral & Antimicrobial Countermeasures Discovery & Development Core (herein abbreviated as A2CD2C) will facilitate biomedical research targeted toward the discovery and/or development of countermeasures for prophylactic or therapeutic treatment of human biosafety level 3 (BSL-3) pathogens or BSL-2 pathogens that mandate select agent control. The A2CD2C will enable this research using state-of-the-art equipment for small molecule (1) screening, (2) imaging, (3) liquid chromatography-mass spectrometry (LCMS/MS) services and (4) histology. The core will be housed within the UTHSC Regional Biocontainment Laboratory (RBL) in BSL-3 space. The A2CD2C is significant in that it provides an efficient, integrated, comprehensive platform that will facilitate studies from the initial discovery phase through pre-clinical development within BSL-3 containment. The A2CD2C is unique within the RBL network in its focus on providing LC-MS studies for infected, treated animal tissues in BSL-3 to provide much needed information of the site of exposure of the therapeutic at the site of infection and thereby providing important pharmacodynamic information required for preclinical assessment. The major mission of the A2CD2C is to maintain, improve and expand our RBL support services in drug discovery and development with a focus on drug pharmacodynamics in terms of how and how much drug exposure impacts pathogen survival. We propose three objectives to achieve herein: Objective 1. To maintain A2CD2C support services in drug discovery and development; Objective 2. To improve A2CD2C support services in drug discovery and development; and Objective 3. To expand A2CD2C support services in imaging in drug discovery and development.