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Exercise vs. Heat Therapy Effects on Kidney Function in Adults with Untreated Hypertension

运动与热疗对未经治疗的高血压成人肾功能的影响

基本信息

批准号：
10794929
负责人：
Christopher L Chapman
金额：
$ 0.63万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2023-06-02
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10794929
关键词：
Acceleration Adult Albumins Albuminuria Angiotensin II Type 1 Receptor Blockers Angiotensin-Converting Enzyme Inhibitors Bathing Biological Blood Pressure Cardiovascular system Chronic Kidney Failure Classification Clinical Trials Data Dietary Intervention Dietary Sodium Environment Excretory function Exercise Exposure to Fellowship Funding General Population Glomerular Filtration Rate Health Health Benefit Heat Stress Disorders Heating Human Hypertension Immersion Incidence Individual Injury Intervention K-Series Research Career Programs Kidney Knowledge LCN2 gene Mentorship Patients Pharmaceutical Preparations Phenotype Physical activity Physiological Prospective, cohort study Publishing Recommendation Renal function Reporting Research Research Personnel Risk Risk Factors Sauna Seminal Temperature Testing Therapeutic heat application Time Training Tubular formation United States National Institutes of Health Urine Water Work aged blood pressure reduction blood pressure regulation cardiovascular disorder prevention efficacy study efficacy testing exercise training hypertension treatment improved normotensive novel pharmacologic prevent urinary

项目摘要

PROJECT SUMMARY/ABSTRACT Hypertension is the leading risk factor for chronic kidney disease (CKD). A recently published 30-year prospective cohort study revealed that the annual rate of decline in estimated glomerular filtration rate (eGFR) is exacerbated in adults with hypertension. Moreover, if albumin is present in the urine (i.e., albumuria), the annual reductions in eGFR are further exacerbated in adults with hypertension. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARBs) are recommended to treat hypertension and for their ability to reduce albuminuria. However, ~54% of adults with hypertension with the highest classification of albuminuria are not currently undergoing treatment with ACEi/ARBs. Thus, there is tremendous opportunity to better develop non-pharmacological approaches that are effective at lowering blood pressure and reducing albuminuria. Unfortunately, however, exercise may not be ideal because only ~45% of patients with hypertension adhere to recommendations for physical activity and some individuals may be unwilling or have limitations where exercise is less feasible. There has been an uptick in research investigating the vast health benefits of heat therapy. Heat therapy refers to the use of frequent episodic increases in core temperature induced by exposures to hot environments, such as sauna bathing or hot water immersion, that ultimately induces beneficial health adaptations. In healthy adults, short-term heat therapy has been shown to reduce the incidence of albuminuria. However, a critical knowledge gap remains if heat therapy provides beneficial adaptations for the kidneys in adults with hypertension, including reducing albuminuria which would lower the risk for CKD. The current study aims investigate whether heat therapy is effective at lowering blood pressure and albuminuria in adults with hypertension. We will compare if 30 sessions of passive heat therapy using hot water immersion over 8-10 weeks reduces albuminuria in adults with untreated Elevated or Stage 1 Hypertension to a greater extent than 30 sessions of exercise training over the same time period. Additionally, we will determine whether 30 sessions of passive heat therapy reduces urinary NGAL to a greater extent than exercise training in adults with untreated Elevated or Stage 1 Hypertension. Demonstrating that heat therapy can be used as a novel treatment for Elevated and Stage 1 Hypertension is timely and important as there is a clear need for alternatives to exercise training and pharmacological approaches.

项目总结/文摘