Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation
ADHD 中的阿尔法振荡和工作记忆缺陷:多模态成像研究
基本信息
- 批准号:10808640
- 负责人:
- 金额:$ 12.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-30 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:Academic achievementAddressAdolescenceAdolescentAttentionAttention deficit hyperactivity disorderAttentional deficitBiological MarkersBrainCharacteristicsChildClinicalDevelopmentElectroencephalographyEventHeterogeneityHigh PrevalenceIndividualInvestigationLifeMeasuresMemory impairmentMethodologyMultimodal ImagingOutcomeOutcomes ResearchParticipantPatientsPerformanceProcessQuality of lifeSamplingShort-Term MemorySpecificityTestingVisual attentioneffective therapyfollow-upfunctional magnetic resonance imaging/electroencephalographyimprovedindexinginsightmemory encodingneuralneuromechanismneurophysiologyneuropsychiatric disordernovelrecruitsocietal costs
项目摘要
Project Summary
High prevalence rates of attention deficit hyperactivity disorder (ADHD) (5-11% of children 4-17 years),
combined with its high societal cost, strong persistence and pernicious effects on quality of life, warrant
continued efforts to understand its underlying neural mechanisms. Underscoring this need is the increasing
recognition that ADHD is clinically and mechanistically heterogeneous, and that this likely degrades the
reliability of putative biomarkers of ADHD. Novel, focused studies that aim to reduce such heterogeneity are
needed. In this project, we aim to define a robust, relatively unexplored putative biomarker of visual attention
deficits, alpha range (8-12Hz) event-related decrease (ERD), which strongly indexes working memory (WM)
deficits in ADHD. Using cutting-edge, concurrent EEG-fMRI recordings, we propose to measure event-related
alpha ERD and its associated brain activation and network connectivity during WM encoding. The concurrent
recordings allow us to directly test if fluctuations in engagement of attention mechanisms captured by the alpha
ERD neurophysiological measures predict fluctuations in WM neural processes. Using this methodology, we
aim to: (a) identify neural mechanisms underlying alpha ERD deficits and WM performance in ADHD, and (b)
define the clinical features of alpha ERD deficits in ADHD, including its effect on real life outcomes such as
academic achievement. Unique to this project, we will sample participants who were previously tested in two
large ADHD-EEG studies, recruiting them for a longitudinal follow-up experimental session if they are currently
in adolescence (14-18 years). By doing so we aim to (c) characterize the developmental trajectory of attention
deficits as captured by alpha ERD in ADHD, as well its impact on the trajectory of clinical and real-life
outcomes. The adolescent sample will provide new insight into neural and neurophysiological characteristics of
ADHD during this developmental period. The outcome of this research is a clearly defined neural mechanism,
alpha ERD, that can be targeted in treatment of WM deficits in ADHD, or in other neuropsychiatric disorders.
项目摘要
注意力缺陷多动障碍(ADHD)患病率高(4-17岁儿童的5-11%),
再加上其高昂的社会成本、强大的持久性和对生活质量的有害影响,
继续努力了解其潜在的神经机制。强调这一需要的是,
认识到ADHD在临床上和机制上是异质的,这可能会降低
ADHD生物标志物的可靠性。旨在减少这种异质性的新的重点研究是
needed.在这个项目中,我们的目标是定义一个强大的,相对未开发的推定生物标志物的视觉注意力
缺陷,α范围(8- 12 Hz)事件相关性降低(ERD),强烈指示工作记忆(WM)
ADHD的缺陷。使用最先进的,同时脑电图功能磁共振成像记录,我们建议测量事件相关的
在WM编码过程中,alpha ERD及其相关的大脑激活和网络连接。并发
记录使我们能够直接测试阿尔法捕捉到的注意力机制的参与波动是否
ERD神经生理学测量预测WM神经过程的波动。使用这种方法,我们
旨在:(a)确定ADHD中α ERD缺陷和WM表现的神经机制,以及(B)
定义ADHD中α ERD缺陷的临床特征,包括其对真实的生活结局的影响,
学术成就独特的这个项目,我们将样本参与者谁是以前测试在两个
大型ADHD-EEG研究,招募他们进行纵向随访实验,如果他们目前
青春期(14-18岁)。通过这样做,我们的目标是(c)描述注意力的发展轨迹
在ADHD中由alpha ERD捕获的缺陷,以及其对临床和现实生活轨迹的影响
结果。青少年样本将为神经和神经生理学特征提供新的见解,
ADHD在这一发展阶段。这项研究的结果是一个明确定义的神经机制,
α ERD,可以靶向治疗ADHD或其他神经精神疾病中的WM缺陷。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Methylphenidate, Guanfacine, and Combined Treatment Effects on Electroencephalography Correlates of Spatial Working Memory in Attention-Deficit/Hyperactivity Disorder.
哌醋甲酯、胍法辛和联合治疗对注意力缺陷/多动障碍中空间工作记忆的脑电图相关性的影响。
- DOI:10.1016/j.jaac.2022.06.017
- 发表时间:2023
- 期刊:
- 影响因子:13.3
- 作者:Michelini,Giorgia;Lenartowicz,Agatha;Diaz-Fong,JoelP;Bilder,RobertM;McGough,JamesJ;McCracken,JamesT;Loo,SandraK
- 通讯作者:Loo,SandraK
Treatment biomarkers for ADHD: Taking stock and moving forward.
- DOI:10.1038/s41398-022-02207-2
- 发表时间:2022-10-12
- 期刊:
- 影响因子:6.8
- 作者:Michelini, Giorgia;Norman, Luke J.;Shaw, Philip;Loo, Sandra K.
- 通讯作者:Loo, Sandra K.
Neurocognitive subprocesses of working memory performance.
- DOI:10.3758/s13415-021-00924-7
- 发表时间:2021-12
- 期刊:
- 影响因子:0
- 作者:Lenartowicz A;Truong H;Enriquez KD;Webster J;Pochon JB;Rissman J;Bearden CE;Loo SK;Bilder RM
- 通讯作者:Bilder RM
Electrophysiological and Clinical Predictors of Methylphenidate, Guanfacine, and Combined Treatment Outcomes in Children With Attention-Deficit/Hyperactivity Disorder.
哌醋甲酯、胍法辛以及注意力缺陷/多动症儿童联合治疗结果的电生理学和临床预测因素。
- DOI:10.1016/j.jaac.2022.08.001
- 发表时间:2023
- 期刊:
- 影响因子:13.3
- 作者:Michelini,Giorgia;Lenartowicz,Agatha;Vera,JuanDiego;Bilder,RobertM;McGough,JamesJ;McCracken,JamesT;Loo,SandraK
- 通讯作者:Loo,SandraK
A new era for executive function research: On the transition from centralized to distributed executive functioning.
- DOI:10.1016/j.neubiorev.2021.02.011
- 发表时间:2021-05
- 期刊:
- 影响因子:8.2
- 作者:Zink N;Lenartowicz A;Markett S
- 通讯作者:Markett S
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Agatha Lenartowicz其他文献
Agatha Lenartowicz的其他文献
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{{ truncateString('Agatha Lenartowicz', 18)}}的其他基金
The neurophysiological basis of interindividual variability (IIV) in ADHD
ADHD 个体差异(IIV)的神经生理学基础
- 批准号:
10660737 - 财政年份:2023
- 资助金额:
$ 12.35万 - 项目类别:
Understanding the neurocognitive mechanisms of alpha-band brain oscillations using concurrent EEG-fMRI recordings
使用并发 EEG-fMRI 记录了解 α 波段脑振荡的神经认知机制
- 批准号:
10706545 - 财政年份:2022
- 资助金额:
$ 12.35万 - 项目类别:
Understanding the neurocognitive mechanisms of alpha-band brain oscillations using concurrent EEG-fMRI recordings
使用并发 EEG-fMRI 记录了解 α 波段脑振荡的神经认知机制
- 批准号:
10528685 - 财政年份:2022
- 资助金额:
$ 12.35万 - 项目类别:
Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation
ADHD 中的阿尔法振荡和工作记忆缺陷:多模态成像研究
- 批准号:
10515331 - 财政年份:2018
- 资助金额:
$ 12.35万 - 项目类别:
Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation
ADHD 中的阿尔法振荡和工作记忆缺陷:多模态成像研究
- 批准号:
10053342 - 财政年份:2018
- 资助金额:
$ 12.35万 - 项目类别:
Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation
ADHD 中的阿尔法振荡和工作记忆缺陷:多模态成像研究
- 批准号:
10305662 - 财政年份:2018
- 资助金额:
$ 12.35万 - 项目类别:
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