Alpha oscillations and working memory deficits in ADHD: A multimodal imaging investigation

ADHD 中的阿尔法振荡和工作记忆缺陷：多模态成像研究

• 批准号: 10808640
• 负责人: Agatha Lenartowicz
• 金额: $ 12.35万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-30 至 2024-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10808640
• 关键词: Academic achievement; Address; Adolescence; Adolescent; Attention; Attention deficit hyperactivity disorder; Attentional deficit; Biological Markers; Brain; Characteristics; Child; Clinical; Development; Electroencephalography; Event; Heterogeneity; High Prevalence; Individual; Investigation; Life; Measures; Memory impairment; Methodology; Multimodal Imaging; Outcome; Outcomes Research; Participant; Patients; Performance; Process; Quality of life; Sampling; Short-Term Memory; Specificity; Testing; Visual attention; effective therapy; follow-up; functional magnetic resonance imaging/electroencephalography; improved; indexing; insight; memory encoding; neural; neuromechanism; neurophysiology; neuropsychiatric disorder; novel; recruit; societal costs

Project Summary High prevalence rates of attention deficit hyperactivity disorder (ADHD) (5-11% of children 4-17 years), combined with its high societal cost, strong persistence and pernicious effects on quality of life, warrant continued efforts to understand its underlying neural mechanisms. Underscoring this need is the increasing recognition that ADHD is clinically and mechanistically heterogeneous, and that this likely degrades the reliability of putative biomarkers of ADHD. Novel, focused studies that aim to reduce such heterogeneity are needed. In this project, we aim to define a robust, relatively unexplored putative biomarker of visual attention deficits, alpha range (8-12Hz) event-related decrease (ERD), which strongly indexes working memory (WM) deficits in ADHD. Using cutting-edge, concurrent EEG-fMRI recordings, we propose to measure event-related alpha ERD and its associated brain activation and network connectivity during WM encoding. The concurrent recordings allow us to directly test if fluctuations in engagement of attention mechanisms captured by the alpha ERD neurophysiological measures predict fluctuations in WM neural processes. Using this methodology, we aim to: (a) identify neural mechanisms underlying alpha ERD deficits and WM performance in ADHD, and (b) define the clinical features of alpha ERD deficits in ADHD, including its effect on real life outcomes such as academic achievement. Unique to this project, we will sample participants who were previously tested in two large ADHD-EEG studies, recruiting them for a longitudinal follow-up experimental session if they are currently in adolescence (14-18 years). By doing so we aim to (c) characterize the developmental trajectory of attention deficits as captured by alpha ERD in ADHD, as well its impact on the trajectory of clinical and real-life outcomes. The adolescent sample will provide new insight into neural and neurophysiological characteristics of ADHD during this developmental period. The outcome of this research is a clearly defined neural mechanism, alpha ERD, that can be targeted in treatment of WM deficits in ADHD, or in other neuropsychiatric disorders.

项目概要 注意力缺陷多动障碍 (ADHD) 的患病率很高（4-17 岁儿童的 5-11%）， 加上其高昂的社会成本、强烈的持久性以及对生活质量的有害影响，有理由 继续努力了解其潜在的神经机制。日益强调这一需求的是 认识到 ADHD 在临床和机制上是异质的，这可能会降低 ADHD 假定生物标志物的可靠性。旨在减少这种异质性的新颖、重点研究是 需要。在这个项目中，我们的目标是定义一个稳健的、相对未经探索的视觉注意力假定生物标志物 赤字、α 范围 (8-12Hz) 事件相关减少 (ERD)，强烈索引工作记忆 (WM) 多动症缺陷。我们建议使用尖端的并发 EEG-fMRI 记录来测量与事件相关的 WM 编码过程中的 alpha ERD 及其相关的大脑激活和网络连接。并发的 录音使我们能够直接测试 alpha 捕获的注意力机制的参与波动是否 ERD 神经生理学测量可预测 WM 神经过程的波动。使用这种方法，我们 目的是：(a) 确定 ADHD 中 alpha ERD 缺陷和 WM 表现的神经机制，以及 (b) 定义 ADHD α ERD 缺陷的临床特征，包括其对现实生活结果的影响，例如 学术成就。该项目的独特之处在于，我们将对之前在两个项目中进行过测试的参与者进行抽样 大型 ADHD-EEG 研究，招募他们进行纵向后续实验（如果他们目前正在） 青春期（14-18 岁）。通过这样做，我们的目标是 (c) 描述注意力的发展轨迹 阿尔法 ERD 在 ADHD 中捕获的缺陷，以及它对临床和现实生活轨迹的影响 结果。青少年样本将为了解青少年的神经和神经生理学特征提供新的见解 在此发育时期的多动症。这项研究的成果是一个明确定义的神经机制， α ERD，可用于治疗 ADHD 或其他神经精神疾病中的 WM 缺陷。

项目成果

Methylphenidate, Guanfacine, and Combined Treatment Effects on Electroencephalography Correlates of Spatial Working Memory in Attention-Deficit/Hyperactivity Disorder.

哌醋甲酯、胍法辛和联合治疗对注意力缺陷/多动障碍中空间工作记忆的脑电图相关性的影响。

• DOI: 10.1016/j.jaac.2022.06.017
• 发表时间: 2023
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Michelini,Giorgia;Lenartowicz,Agatha;Diaz-Fong,JoelP;Bilder,RobertM;McGough,JamesJ;McCracken,JamesT;Loo,SandraK
• 通讯作者: Loo,SandraK

Treatment biomarkers for ADHD: Taking stock and moving forward.

• DOI: 10.1038/s41398-022-02207-2
• 发表时间: 2022-10-12
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Michelini, Giorgia;Norman, Luke J.;Shaw, Philip;Loo, Sandra K.
• 通讯作者: Loo, Sandra K.

Neurocognitive subprocesses of working memory performance.

• DOI: 10.3758/s13415-021-00924-7
• 发表时间: 2021-12
• 期刊: Cognitive, affective & behavioral neuroscience
• 作者: Lenartowicz A;Truong H;Enriquez KD;Webster J;Pochon JB;Rissman J;Bearden CE;Loo SK;Bilder RM
• 通讯作者: Bilder RM

Electrophysiological and Clinical Predictors of Methylphenidate, Guanfacine, and Combined Treatment Outcomes in Children With Attention-Deficit/Hyperactivity Disorder.

哌醋甲酯、胍法辛以及注意力缺陷/多动症儿童联合治疗结果的电生理学和临床预测因素。

• DOI: 10.1016/j.jaac.2022.08.001
• 发表时间: 2023
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Michelini,Giorgia;Lenartowicz,Agatha;Vera,JuanDiego;Bilder,RobertM;McGough,JamesJ;McCracken,JamesT;Loo,SandraK
• 通讯作者: Loo,SandraK

A new era for executive function research: On the transition from centralized to distributed executive functioning.

• DOI: 10.1016/j.neubiorev.2021.02.011
• 发表时间: 2021-05
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Zink N;Lenartowicz A;Markett S
• 通讯作者: Markett S