Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments

社会心理慢性疼痛治疗的比较机制(中介、调节因素)

基本信息

  • 批准号:
    10810951
  • 负责人:
  • 金额:
    $ 26.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-26 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

Chronic musculoskeletal pain (CP) is a major public health concern. A number of psychosocial treatments have emerged in recent decades to help address this problem. These interventions have been shown to be efficacious when compared to largely inert control conditions; however, recent meta-analyses indicate that most of these treatments are characterized by modest effects on primary outcomes. This is a critical shortcoming of these otherwise promising approaches. Rather than attempting to boost efficacy only by developing new and hopefully more powerful interventions, we can also look within our already proven treatments for ways to enhance the magnitude of treatment effects. One strategy is to increase our understanding of treatment mediators. Studies of mediators are needed that directly compare different treatments with each other to determine which mediators are treatment-specific, which are shared across treatments, and which contribute the most to clinical outcomes. The findings from such research could be used to inform adaptations to existing treatment that enhance their benefits. A second strategy for increasing the beneficial effects of existing treatments is to identify the patient characteristics that moderate treatment responses. Research is needed that is guided by theoretical models and that tests moderators across multiple treatments. Identifying subgroups of patients more likely to respond to one or another treatment can advance precision medicine by informing a priori patient-treatment matches that can optimize treatment effects. We will compare the mechanisms and moderators of Cognitive-Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT), and Emotional Awareness and Expression Therapy (EAET). Examining the mediators and moderators of these treatments holds great potential for advancing treatment development and enhancing treatment efficacy. Adults with chronic spinal (axial) pain (N=460) will be randomly assigned to CBT, ACT, EAET and to treatment-as-usual (TAU). Aim 1 is to identify specific and shared mediators across treatments. Aim 2 is to identify moderators across treatments. This project can increase the effects of our psychosocial chronic pain treatments by identifying the most powerful treatment mechanisms – specific and shared -- and revealing for whom the mediator  outcome pathways are strongest. Via increased understanding of mediator and moderators, more effective pain treatment approaches can be developed, tested, and implemented.
慢性肌肉骨骼疼痛(CP)是一个主要的公共卫生问题。一些心理治疗

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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John W. Burns其他文献

Mechanisms in psychosocial treatments of chronic pain: What does the evidence tell us?
慢性疼痛心理社会治疗的机制:证据告诉了我们什么?
  • DOI:
    10.1016/j.copsyc.2025.102050
  • 发表时间:
    2025-08-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    John W. Burns
  • 通讯作者:
    John W. Burns
Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity
单纯疱疹病毒感染的抗独特型调节导致致病性增加
  • DOI:
    10.1128/jvi.50.3.951-953.1984
  • 发表时间:
    1984
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    Ronald C. Kennedy;Karen Adler;John W. Burns;Richard D. Henkel;G. Dreesman
  • 通讯作者:
    G. Dreesman
The electrocardiogram from miniature swine recorded with the McFee-axial reference program
  • DOI:
    10.1016/s0022-0736(74)80025-7
  • 发表时间:
    1974-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Robert L. Hamlin;Russell R. Burton;Sidney D. Leverett;John W. Burns
  • 通讯作者:
    John W. Burns
Anger inhibition and pain: conceptualizations, evidence and new directions
  • DOI:
    10.1007/s10865-008-9154-7
  • 发表时间:
    2008-05-23
  • 期刊:
  • 影响因子:
    2.900
  • 作者:
    John W. Burns;Phillip J. Quartana;Stephen Bruehl
  • 通讯作者:
    Stephen Bruehl
Self-rated pain and observed pain behavior in Black and White Americans with chronic low back pain
患有慢性下腰痛的美国黑人和白人的自评疼痛情况与可观察到的疼痛行为
  • DOI:
    10.1016/j.jpain.2025.105338
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Matthew B. Jennings;John W. Burns;Benita Jackson;Kristine M. Molina;Mark A. Lumley
  • 通讯作者:
    Mark A. Lumley

John W. Burns的其他文献

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{{ truncateString('John W. Burns', 18)}}的其他基金

Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗的比较机制(中介、调节因素)
  • 批准号:
    10710208
  • 财政年份:
    2022
  • 资助金额:
    $ 26.15万
  • 项目类别:
Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
全膝关节置换术患者从急性疼痛到慢性疼痛的转变:确定恢复力和脆弱性概况
  • 批准号:
    10593786
  • 财政年份:
    2022
  • 资助金额:
    $ 26.15万
  • 项目类别:
Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗的比较机制(中介、调节因素)
  • 批准号:
    10564263
  • 财政年份:
    2022
  • 资助金额:
    $ 26.15万
  • 项目类别:
Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
全膝关节置换术患者从急性疼痛到慢性疼痛的转变:确定恢复力和脆弱性概况
  • 批准号:
    9812647
  • 财政年份:
    2019
  • 资助金额:
    $ 26.15万
  • 项目类别:
Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
全膝关节置换术患者从急性疼痛到慢性疼痛的转变:确定恢复力和脆弱性概况
  • 批准号:
    10231116
  • 财政年份:
    2019
  • 资助金额:
    $ 26.15万
  • 项目类别:
Development of Co-Morbid PTSD and Chronic Pain Among Inner-City Women
内城区女性共病创伤后应激障碍 (PTSD) 和慢性疼痛的发展
  • 批准号:
    9095272
  • 财政年份:
    2015
  • 资助金额:
    $ 26.15万
  • 项目类别:
Development of Co-Morbid PTSD and Chronic Pain Among Inner-City Women
内城区女性共病创伤后应激障碍 (PTSD) 和慢性疼痛的发展
  • 批准号:
    9490306
  • 财政年份:
    2015
  • 资助金额:
    $ 26.15万
  • 项目类别:
Mechanisms of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗机制
  • 批准号:
    9130041
  • 财政年份:
    2013
  • 资助金额:
    $ 26.15万
  • 项目类别:
Mechanisms of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗机制
  • 批准号:
    8740557
  • 财政年份:
    2013
  • 资助金额:
    $ 26.15万
  • 项目类别:
Mechanisms of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗机制
  • 批准号:
    8880001
  • 财政年份:
    2013
  • 资助金额:
    $ 26.15万
  • 项目类别:

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