Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma

原发性开角型青光眼多基因风险预测中优先考虑多样性

• 批准号: 10813253
• 负责人: Jessica N Cooke Bailey
• 金额: $ 13.87万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10813253
• 关键词: Acceleration; Administrative Supplement; Africa; African ancestry; Categories; Clinical Data; Data; Data Set; Doctor of Philosophy; Ensure; Exposure to; Eye; Funding; Genetic; Geography; Glaucoma; Goals; Grant; Individual; International; Lead; Meta-Analysis; Methods; Minority Groups; Nigeria; Parents; Primary Open Angle Glaucoma; Research; Risk; Sample Size; Site; Statistical Methods; Structure; United States National Institutes of Health; Universities; Work; genome wide association study; genome-wide analysis; member; parent grant; risk prediction; statistics; time use

Abstract This administrative supplement will facilitate completion of the specific aims of the parent grant, R01EY033829 Prioritizing Diversity in Polygenic Risk for Primary Open-Angle Glaucoma, in several ways. The parent grant structure is a consortium of research groups, each of whom have genome-wide association (GWAS) data from individuals of global African ancestry with ocular data evaluated by experts and categorized as glaucoma cases or controls. Each contributing member of the consortium will conduct analyses on their own data and submit summary statistics for meta-analysis to the PI, Dr. Jessica Cooke Bailey, and her group at Case Western Reserve University (CWRU). One key contributing member of the consortium is the Eyes of Africa group, based in Ibadan, Nigeria. This group has collected GWAS and clinical data from more than 6500 individuals with continental African ancestry, comprising an especially powerful dataset due to geographic ancestry and sample size. This administrative supplement will enable the Eyes of Africa statistician, Dr. Onoja Akpa, PhD, to work alongside the team of Dr. Cooke Bailey, an international leader in the field of glaucoma genetics, to complete analyses described in the specific aims of the parent R01. This will be accomplished via Dr. Akpa’s exposure to and real-time use of the most up-to-date methods for statistical analysis of GWAS data. This supplement will not only ensure the efficient completion of the proposed parent grant aims, but will also greatly enhance Dr. Akpa’s ability to conduct further analyses for the parent grant once he returns to the University of Ibadan. It will also serve to enhance the involvement of minority individuals in NIH-funded research.

抽象的 这种行政补充将有助于完成父母赠款的具体目标R01EY033829 优先考虑多基因开放角度青光眼的多基因风险多样性。父母赠款 结构是研究小组的联盟，每个联盟都有来自全基因组关联（GWAS）的数据 由专家评估并归类为青光眼的全球非洲血统的个人 案例或控件。财团的每个贡献成员将对自己的数据进行分析，并 将荟萃分析的摘要统计数据提交PI，Jessica Cooke Bailey博士及其小组。 西部储备大学（CWRU）。财团的一个关键贡献者是非洲的眼睛 集团，总部位于尼日利亚伊巴丹。该组收集了6500多个的GWA和临床数据 具有连续非洲血统的人，由于地理而完成了一个特别强大的数据集 祖先和样本量。这种行政补充将使非洲统计学家Onoja博士的眼睛能够。 AKPA，博士，与青光眼领域的国际领导人库克·贝利（Cooke Bailey）博士一起工作 遗传学，以完成父r01的特定目的中描述的分析。这将通过 AKPA博士对GWAS数据的统计分析的最新方法的实时使用和实时使用。 该补充不仅将确保有效完成拟议的父母赠款的目标，还将 一旦他返回到父母，他大大提高了AKPA博士对父母赠款进行进一步分析的能力 伊巴丹大学。它还将有助于增强少数族裔在NIH资助中的参与 研究。