Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma

摘要 这一行政补充将有助于完成家长补助金R01EY033829的具体目标 以多种方式对原发性开角型青光眼多基因风险的多样性进行优先排序。家长助学金 Structure是一个研究小组的联盟，每个小组都有来自 全球非洲血统的人，其眼部数据经专家评估并归类为青光眼 病例或对照。财团的每个贡献成员将对自己的数据进行分析，并 将汇总统计数据提交给私人助理Jessica Cooke Bailey博士和她在Case的小组进行荟萃分析 西部储备大学(CWRU)。该财团的一个关键贡献成员是非洲之眼 集团，总部设在尼日利亚的伊巴丹。该小组已经从6500多个国家收集了GWAS和临床数据 非洲大陆血统的个人，由于地理位置的原因，构成了一个特别强大的数据集 血统和样本规模。这一行政副刊将使非洲统计学家奥诺贾博士能够 Akpa博士与青光眼领域的国际领先者Cooke Bailey博士的团队合作 遗传学，完成在亲本R01的特定目标中描述的分析。这将通过以下方式实现 Akpa博士接触并实时使用最新的方法对全球气候变化数据进行统计分析。 这项补助金不仅可确保有效率地完成拟议的家长资助目标，而且还将 极大地增强了Akpa博士在返回到 伊巴丹大学。它还将有助于加强少数族裔个人对美国国立卫生研究院资助的 研究。

Abstract This administrative supplement will facilitate completion of the specific aims of the parent grant, R01EY033829 Prioritizing Diversity in Polygenic Risk for Primary Open-Angle Glaucoma, in several ways. The parent grant structure is a consortium of research groups, each of whom have genome-wide association (GWAS) data from individuals of global African ancestry with ocular data evaluated by experts and categorized as glaucoma cases or controls. Each contributing member of the consortium will conduct analyses on their own data and submit summary statistics for meta-analysis to the PI, Dr. Jessica Cooke Bailey, and her group at Case Western Reserve University (CWRU). One key contributing member of the consortium is the Eyes of Africa group, based in Ibadan, Nigeria. This group has collected GWAS and clinical data from more than 6500 individuals with continental African ancestry, comprising an especially powerful dataset due to geographic ancestry and sample size. This administrative supplement will enable the Eyes of Africa statistician, Dr. Onoja Akpa, PhD, to work alongside the team of Dr. Cooke Bailey, an international leader in the field of glaucoma genetics, to complete analyses described in the specific aims of the parent R01. This will be accomplished via Dr. Akpa’s exposure to and real-time use of the most up-to-date methods for statistical analysis of GWAS data. This supplement will not only ensure the efficient completion of the proposed parent grant aims, but will also greatly enhance Dr. Akpa’s ability to conduct further analyses for the parent grant once he returns to the University of Ibadan. It will also serve to enhance the involvement of minority individuals in NIH-funded research.