Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma

摘要 该行政补充将有助于完成父母补助金R01EY033829的具体目标。 在几个方面优先考虑原发性开角型青光眼多基因风险的多样性。父母补助金 结构是一个研究小组的联盟，每个研究小组都有来自 全球非洲血统的个体，其眼部数据经专家评估并归类为青光眼 病例或对照。联合体的每个贡献成员将对自己的数据进行分析， 向PI Jessica Cooke Bailey博士及其病例组提交荟萃分析的汇总统计数据 西储大学（CWRU）。该联合会的一个主要贡献成员是非洲之眼 总部位于尼日利亚伊巴丹。该小组收集了来自6500多个国家的GWAS和临床数据， 具有非洲大陆血统的个体，由于地理原因， 血统和样本量。这一行政补充将使非洲之眼统计员Onoja博士 Akpa博士将与青光眼领域的国际领导者Cooke Bailey博士的团队一起工作 遗传学，以完成在亲本R01的具体目标中描述的分析。这将通过 博士Akpa接触并实时使用最新的GWAS数据统计分析方法。 这笔补助金不仅将确保有效地完成拟议的家长补助金目标，而且还将 大大提高博士Akpa的能力进行进一步的分析，一旦他回到父母补助金 伊巴丹大学。它还将有助于加强少数民族个人参与NIH资助的 research.

Abstract This administrative supplement will facilitate completion of the specific aims of the parent grant, R01EY033829 Prioritizing Diversity in Polygenic Risk for Primary Open-Angle Glaucoma, in several ways. The parent grant structure is a consortium of research groups, each of whom have genome-wide association (GWAS) data from individuals of global African ancestry with ocular data evaluated by experts and categorized as glaucoma cases or controls. Each contributing member of the consortium will conduct analyses on their own data and submit summary statistics for meta-analysis to the PI, Dr. Jessica Cooke Bailey, and her group at Case Western Reserve University (CWRU). One key contributing member of the consortium is the Eyes of Africa group, based in Ibadan, Nigeria. This group has collected GWAS and clinical data from more than 6500 individuals with continental African ancestry, comprising an especially powerful dataset due to geographic ancestry and sample size. This administrative supplement will enable the Eyes of Africa statistician, Dr. Onoja Akpa, PhD, to work alongside the team of Dr. Cooke Bailey, an international leader in the field of glaucoma genetics, to complete analyses described in the specific aims of the parent R01. This will be accomplished via Dr. Akpa’s exposure to and real-time use of the most up-to-date methods for statistical analysis of GWAS data. This supplement will not only ensure the efficient completion of the proposed parent grant aims, but will also greatly enhance Dr. Akpa’s ability to conduct further analyses for the parent grant once he returns to the University of Ibadan. It will also serve to enhance the involvement of minority individuals in NIH-funded research.