Site-specific control of human gene regulation for therapeutically applicable mechanistic insights (R35GM143532)

人类基因调控的位点特异性控制以获得治疗上适用的机制见解（R35GM143532）

• 批准号: 10807287
• 负责人: Isaac Hilton
• 金额: $ 0.9万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10807287
• 关键词: Gene Expression Regulation; Human; Site; Therapeutic; insight

Project Summary is not required for this submission.

此提交不需要项目摘要。

项目成果

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control.

• DOI: 10.1038/s41592-023-02036-1
• 发表时间: 2023-11
• 期刊: NATURE METHODS
• 影响因子: 48
• 作者: Mahata, Barun;Cabrera, Alan;Brenner, Daniel A.;Guerra-Resendez, Rosa Selenia;Li, Jing;Goell, Jacob;Wang, Kaiyuan;Guo, Yannie;Escobar, Mario;Parthasarathy, Abinand Krishna;Szadowski, Hailey;Bedford, Guy;Reed, Daniel R.;Kim, Sunghwan;Hilton, Isaac B.
• 通讯作者: Hilton, Isaac B.

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions.

• DOI: 10.1093/nar/gkac582
• 发表时间: 2022-08-12
• 期刊: NUCLEIC ACIDS RESEARCH
• 影响因子: 14.9
• 作者: Wang, Kaiyuan;Escobar, Mario;Li, Jing;Mahata, Barun;Goell, Jacob;Shah, Spencer;Cluck, Madeleine;Hilton, Isaac B.
• 通讯作者: Hilton, Isaac B.

Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells.

• DOI: 10.1021/acssynbio.2c00156
• 发表时间: 2022-10-21
• 期刊: ACS SYNTHETIC BIOLOGY
• 影响因子: 4.7
• 作者: Escobar, Mario;Li, Jing;Patel, Aditi;Liu, Shizhe;Xu, Qi;Hilton, Isaac B.
• 通讯作者: Hilton, Isaac B.