Delphi and associated resources: maintenance and further development; Administrative Supplements to Support Undergraduate Summer Research Experiences

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With this administrative supplement we are seeking support for summer salary for a undergraduate student, Mr. Nicolas Ancona, who is currently working with us as a volunteer. The original R01GM093937 grant does not have funds designated for undergraduate student’s research and we are using this administrative supplement option to support Mr. Ancona for summer research in 2023. He will be working on a project which within is along the aims of the original R01GM093937 proposal, namely to further benchmark SAMPDI-3D software and to test its performance of various set of cases, specifically on single nucleotide variants. I will be closely monitor his work and provide the training. Such a research will contribute to Mr. Ancona professional growth, will enable him to develop skills to carry out scientific investigations and to work with other researchers. From scientific point of view, the investigation will demonstrate the distribution of the binding free energy changes caused by mutations in case of protein-DNA complexes, emphasizing on the differences between researcher-initiated mutations versus mutations that can be observed in human population.