Maintenance of an SPF Macaque Breeding Colony for AIDS Research

维持 SPF 猕猴繁殖群以进行艾滋病研究

• 批准号: 10808548
• 负责人: KASI E RUSSELL-LODRIGUE
• 金额: $ 41.88万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-09 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10808548
• 关键词: Acclimatization; Accounting; Acquired Immunodeficiency Syndrome; Address; Animal Welfare; Animals; Award; Behavioral; Breeding; Caring; Chronic; Collaborations; Communities; Conscious; Distress; Engineering; Environment; Equipment; Food; Funding; Future; HIV/AIDS; Hospitals; Housing; Infection Control; Macaca; Macaca mulatta; Maintenance; Medicine; Methods; Parents; Pathogenesis; Personal Satisfaction; Physical environment; Positive Reinforcements; Primates; Procedures; Reproducibility; Research; Research Personnel; Research Priority; Research Project Grants; Resources; Safety; Sanitation; Security; System; Therapeutic; Time; Training; Training Programs; United States National Institutes of Health; Veterinarians; Well in self; Workplace; animal care; animal safety; antiretroviral therapy; co-infection; comparative; design; ergonomics; experimental study; flexibility; germ free condition; improved; innovation; microbicide; nonhuman primate; parent grant; pre-exposure prophylaxis; programs; response; social; transmission process; vaccine development

PROJECT SUMMARY/ABSTRACT NIH award U42OD010568 funds the establishment and maintenance of a Tulane National Primate Research Center (TNPRC) specific pathogen free (SPF) breeding colony of rhesus macaques to support AIDS research. The TNPRC AIDS research program is the largest at the Center, currently accounting for 61% of all research grant funding and 67% of animals assigned to research at the TNPRC on an annual basis. The SPF breeding colony also provides rhesus macaques to affiliate investigators outside of the TNPRC for AIDS research. The TNPRC SPF program supports a variety of AIDS studies which are aligned with NIH’s HIV/AIDS research priorities including vaccine development, pre-exposure prophylaxis, microbicides, AIDS/TB coinfection, transmission pathogenesis, and cure research. The high national demand for SPF macaques requires the continued availability and enhancement of this resource. As part of its program for continuous improvement, the TNPRC continuously assesses and refines indoor nonhuman primate (NHP) caging equipment to facilitate social housing, expand methods for the provision of food-related and inanimate enrichment, improve safety and ergonomics for animal care staff, maximize infection control, and increase flexibility in housing configurations to accommodate a variety of research requirements. Teams of engineers have collaborated with the TNPRC animal care staff, behavioral management staff, and veterinarians to create designs to meet the specialized needs of the program and improve animal wellbeing. The most impactful attribute of these caging systems involves maximizing the use of social housing. Several ongoing and proposed AIDS studies require that NHP receive long term antiretroviral therapy (ART). Positive reinforcement training is being implemented to optimize the administration of ART while minimizing distress and improving animal welfare. The caging system proposed here will enhance the physical environment, address the needs of our positive reinforcement training program, and promote consistency and minimize variability in the care of NHP thereby improving scientific rigor and reproducibility. If funds are awarded for this proposal, they will be used to purchase an innovative caging system that enhances the environment by joining vertical as well as horizontal spaces, expands social housing opportunities, facilitates positive reinforcement training of rhesus macaques, and improves ergonomics and safety for staff caring for animals in the TNPRC AIDS SPF breeding colony supported by NIH U42OD010568. The request is within the original scope of the parent award to maintain the existing SPF colony and distribute available animals to the NIH-funded HIV/AIDS research community and there is no overlap with this project and the parent grant.

项目概要/摘要 NIH 奖 U42OD010568 资助杜兰国家灵长类动物研究中心的建立和维护 中心 (TNPRC) 恒河猴无特定病原体 (SPF) 繁殖群，以支持艾滋病研究。 TNPRC 艾滋病研究项目是该中心最大的项目，目前占所有研究的 61% 每年都会拨款资助，并将 67% 的动物分配到 TNPRC 进行研究。 SPF育种 Colony 还向 TNPRC 以外的附属研究人员提供恒河猴，用于艾滋病研究。这 TNPRC SPF 计划支持与 NIH 的 HIV/AIDS 研究相一致的各种艾滋病研究 优先事项包括疫苗开发、暴露前预防、杀菌剂、艾滋病/结核病合并感染、 传播发病机制和治疗研究。国家对 SPF 猕猴的高需求需要 该资源的持续可用性和增强。 作为持续改进计划的一部分，TNPRC 不断评估和完善室内 非人类灵长类动物 (NHP) 笼养设备，以促进社会住房，扩大提供 食品相关和无生命的富集，提高动物护理人员的安全性和人体工程学，最大限度地提高感染率 控制，并提高外壳配置的灵活性，以满足各种研究要求。 工程师团队与 TNPRC 动物护理人员、行为管理人员和 兽医进行设计以满足该计划的特殊需求并改善动物福祉。这 这些笼养系统最有影响力的属性是最大限度地利用社会住房。多项正在进行中 拟议的艾滋病研究要求 NHP 接受长期抗逆转录病毒治疗 (ART)。积极的 正在实施强化训练，以优化 ART 的管理，同时最大限度地减少痛苦和 改善动物福利。这里提出的笼养系统将改善物理环境，解决 的积极强化训练计划的需求，并促进一致性并最大限度地减少可变性 NHP 的护理从而提高了科学严谨性和可重复性。 如果该提案获得资金，它们将用于购买创新的笼养系统，以增强 通过连接垂直和水平空间，扩大社会住房机会，促进环境 对恒河猴进行正向强化训练，并改善护理人员的人体工程学和安全性 由 NIH U42OD010568 支持的 TNPRC AIDS SPF 繁殖群中的动物。该请求在 父母奖励的最初范围是维持现有的 SPF 群体并将可用的动物分配给 NIH 资助的艾滋病毒/艾滋病研究团体与该项目和家长资助没有重叠。