Sheltered Outdoor Housing Expansion for the TNPRC SPF Rhesus Macaque Breeding Colony

项目概要/摘要 杜兰大学杜兰国家灵长类动物研究中心（TNPRC）是七个国家灵长类动物研究中心之一。 研究中心（NPRC）由美国国立卫生研究院赞助。该中心致力于提供 基础设施和支持基础和应用研究工作，以促进科学知识和提高 人类和动物的健康和福祉。NPRC计划为研究提供资源和机会 使用非人类灵长类动物（NHP）的核心教师和教师附属于外部机构。TNPRC 无特定病原体（SPF）恒河猴繁殖群是NPRC计划中最大的繁殖群之一， 大约5000人的人口普查在过去的5年里，TNPRC SPF繁殖群提供了2，099只 为美国各地的核心和附属研究人员的研究项目提供动物。继续有高 国家对SPF恒河猴的需求，目前NPRC的饲养操作无法满足。2018年， 国家卫生研究院赞助了NHP评估和分析项目，以加强对需求的理解， 在美国境内的NHP供应。为确保生物医学领域国家卫生保健品的充足供应而提出的主要建议 研究包括改善基础设施和为SPF NHP繁殖群体扩大提供支持。以来 2018年报告的结果公布后，TNPRC进行了评估，以确定需求 扩大SPF恒河猴繁殖群的计划。沿着NIH的资助， 已承诺资金和启动项目：1）改善繁殖群体管理计划和2） 扩大基础设施，以满足当前和预计未来的国家需求。的主成分 改善基础设施的长期计划是增加室内/室外住房的数量 配置，以增加NHP免受恶劣天气的保护，并补充现有的室外NHP 外壳外壳。要求提供资金，在繁殖地建造室内/室外围栏 校园的目的是住房和繁殖SPF恒河猴。该项目将增加设施，以支持 我们承诺扩大用于NIH确定的优先研究领域的SPF恒河猴的生产 在全国和全国。这些设施的设计符合我们的长期基础设施 改善计划，以加强保护动物，增加住房容量和灵活性，并提供新的 和经过验证的环境增强成分。这种基础设施所产生的动物 改善项目将有助于解决全国SPF猕猴短缺的问题。

PROJECT SUMMARY / ABSTRACT The Tulane National Primate Research Center (TNPRC) of Tulane University is one of seven National Primate Research Centers (NPRC) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and well-being. The NPRC program provides resources and opportunities for research using nonhuman primates (NHP) to core faculty and faculty affiliated with outside institutions. The TNPRC specific pathogen free (SPF) rhesus macaque breeding colony is among the largest in the NPRC program, with a census of approximately 5,000. Over the past 5 years, the TNPRC SPF breeding colonies have supplied 2,099 animals for research programs of core and affiliate investigators across the US. There continues to be high national demand for SPF rhesus macaques which cannot be met by current NPRC breeding operations. In 2018, the NIH sponsored the NHP Evaluation and Analysis Project to enhance understanding of the demand for and supply of NHP within the US. Key recommendations made to ensure the adequate supply of NHPs for biomedical research included improving infrastructure and providing support for SPF NHP breeding colony expansion. Since the results of the 2018 report were made public, the TNPRC has undertaken assessments to identify the needs of the program to expand its SPF rhesus macaque breeding colony. Along with funding from the NIH, the TNPRC has committed funds and initiated projects to: 1) improve the breeding colony management program and 2) expand infrastructure to meet the current and projected future national demand. Principal components of the long-term plan for infrastructure improvement are to increase the number of indoor/outdoor housing configurations for added protection of NHP from inclement weather and complement the existing outdoor NHP housing enclosures. Funding is requested to construct indoor/outdoor enclosures located on the breeding colony campus for the purpose of housing and breeding SPF rhesus macaques. This project will add facilities to support our commitment to expand production of SPF rhesus macaques used for NIH-established priority research areas at the TNPRC and nationally. The facilities have been designed in alignment with our long-term infrastructure improvement plan to enhance protection of animals, increase housing capacity and flexibility, and provide novel and proven environmental enhancement components. The animals produced as a result of this infrastructure improvement project will help address the national shortage of SPF macaques.