Sheltered Outdoor Housing Expansion for the TNPRC SPF Rhesus Macaque Breeding Colony

TNPRC SPF 恒河猴繁殖地的庇护室外房屋扩建

• 批准号: 10588719
• 负责人: KASI E RUSSELL-LODRIGUE
• 金额: $ 649.98万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588719
• 关键词: Address; Animal Experimentation; Animals; Applied Research; Area; Basic Science; Biomedical Research; Breeding; Censuses; Complement; Ensure; Evaluation; Faculty; Funding; Future; Health; Housing; Human; Infrastructure; Institution; Knowledge; Macaca; Macaca mulatta; Personal Satisfaction; Primates; Production; Recommendation; Reporting; Research; Research Personnel; Research Priority; Resources; Scientific Advances and Accomplishments; United States National Institutes of Health; Universities; Weather; design; flexibility; germ free condition; improved; nonhuman primate; novel; operation; programs

PROJECT SUMMARY / ABSTRACT The Tulane National Primate Research Center (TNPRC) of Tulane University is one of seven National Primate Research Centers (NPRC) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and well-being. The NPRC program provides resources and opportunities for research using nonhuman primates (NHP) to core faculty and faculty affiliated with outside institutions. The TNPRC specific pathogen free (SPF) rhesus macaque breeding colony is among the largest in the NPRC program, with a census of approximately 5,000. Over the past 5 years, the TNPRC SPF breeding colonies have supplied 2,099 animals for research programs of core and affiliate investigators across the US. There continues to be high national demand for SPF rhesus macaques which cannot be met by current NPRC breeding operations. In 2018, the NIH sponsored the NHP Evaluation and Analysis Project to enhance understanding of the demand for and supply of NHP within the US. Key recommendations made to ensure the adequate supply of NHPs for biomedical research included improving infrastructure and providing support for SPF NHP breeding colony expansion. Since the results of the 2018 report were made public, the TNPRC has undertaken assessments to identify the needs of the program to expand its SPF rhesus macaque breeding colony. Along with funding from the NIH, the TNPRC has committed funds and initiated projects to: 1) improve the breeding colony management program and 2) expand infrastructure to meet the current and projected future national demand. Principal components of the long-term plan for infrastructure improvement are to increase the number of indoor/outdoor housing configurations for added protection of NHP from inclement weather and complement the existing outdoor NHP housing enclosures. Funding is requested to construct indoor/outdoor enclosures located on the breeding colony campus for the purpose of housing and breeding SPF rhesus macaques. This project will add facilities to support our commitment to expand production of SPF rhesus macaques used for NIH-established priority research areas at the TNPRC and nationally. The facilities have been designed in alignment with our long-term infrastructure improvement plan to enhance protection of animals, increase housing capacity and flexibility, and provide novel and proven environmental enhancement components. The animals produced as a result of this infrastructure improvement project will help address the national shortage of SPF macaques.

项目摘要/摘要 杜兰大学国家灵长类研究中心(TNPRC)是七个国家灵长类之一 研究中心(NPRC)由美国国立卫生研究院赞助。该中心致力于提供 基础设施和对基础研究和应用研究的支持，以促进科学知识和改进 人类和动物的健康和福祉。NPRC计划为研究提供资源和机会 使用非人类灵长类动物(NHP)为核心教员和附属于外部机构的教员。TNPRC 无特定病原体(SPF)猕猴繁殖群体是NPRC计划中最大的群体之一，有 大约5000人的人口普查。在过去的5年里，TNPRC SPF繁殖群体提供了2099个 为全美核心和附属调查人员的研究项目提供动物。持续高企 国家对SPF猕猴的需求，目前NPRC的饲养行动无法满足这一需求。2018年， 国家卫生研究院赞助了国家卫生计划评估和分析项目，以加强对国家卫生计划需求的了解和 美国国内的NHP供应。为确保生物医学用NHP的充足供应而提出的主要建议 研究包括改善基础设施和为SPF NHP育种群体扩张提供支持。自.以来 2018年报告结果公布，TNPRC已进行评估，以确定需求 扩大其SPF恒河猴繁殖群体的计划。除了来自国家卫生研究院的资金外，TNPRC 已承诺提供资金并发起以下项目：1)改善繁殖群体管理计划；2) 扩大基础设施，以满足当前和预测的未来国家需求。主成分股 改善基础设施的长期计划是增加室内/室外住房的数量 用于增加NHP免受恶劣天气影响的配置，并补充现有的室外NHP 住房封闭物。需要资金来建造位于繁殖地的室内/室外围栏。 校园内以饲养SPF级恒河猴为目的。该项目将增加设施以支持 我们承诺扩大SPF猕猴的生产，用于NIH-确立的优先研究领域 在TNPRC和全国范围内。这些设施的设计与我们的长期基础设施保持一致。 改善计划，以加强对动物的保护，增加住房容量和灵活性，并提供新颖的 和经过验证的环境增强组件。由于这种基础设施而产生的动物 改进项目将有助于解决全国SPF猕猴短缺的问题。