Crimson - i2b2 integration for high-throughput, scalable sample collection

描述(由申请人提供)： 缺乏良好的表型样本仍然是生物医学研究的一个关键瓶颈。与收集相关的成本通常超过与发现过程中的任何其他步骤相关的成本。Crimson应用程序通过以下方式解决这些问题：(1)实时查询来自临床实验室的废弃样本，(2)利用i2b2的S工具(用于将生物学整合到床边的信息学)生成的队列，为IRB批准的研究实现高通量、高成本效益的样本收集。Crimson与i2b2的使用显著降低了研究人员与样本收集相关的成本，通常减少了1-2个数量级，同时也增加了IRB批准的研究可用的材料吞吐量。我们相信，将Crimson完全整合为i2b2细胞将进一步在地方和国家层面传播这些能力。我们建议开发Crimson词汇表，以提高其在i2b2基础设施中的互操作性，进一步设计和开发分布式查询的方法，从而实现跨机构的高吞吐量样本收集，并开发和测试一个关于Crimson对研究企业影响的经济模型，以便在i2b2中使用Crimson进行研究，以实现大规模研究的高通量样本收集。

DESCRIPTION (provided by applicant): Lack of well-phenotype samples remains a key bottleneck in biomedical research. The costs associated with collection often exceed those associated with any other step in the discovery process. The Crimson application addresses these issues by enabling high-throughput, cost-effective collection of samples for IRB-approved studies by (1) real-time query of discarded samples from Clinical Laboratories and (2) leveraging cohorts generated with i2b2's tools (Informatics for Integrating Biology to the Bedside). Crimson's use with i2b2 has significantly reduced costs associated with sample collection for investigators, often by 1-2 orders of magnitude, while also increasing the throughput of materials available to IRB-approved studies. We believe full integration of Crimson as an i2b2 cell will further promulgate these capabilities at both local and national levels. We propose to develop Crimson vocabularies to increase its interoperability within the i2b2 infrastructure, further design and develop means for distributed queries enabling high-throughput sample collection across institutions, and develop and test an economic model of Crimson's impact upon a research enterprise for studies using Crimson within i2b2 to enable high-throughput sample collection for large-scale research studies.