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Gnotobiotics, Microbiology and Metagenomics Core

知生菌、微生物学和宏基因组学核心

基本信息

批准号：
10049386
负责人：
LYNN BRY
金额：
$ 31.6万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-01 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10049386
关键词：
16S ribosomal RNA sequencing Affect Animal Model Animals Area Award Base Sequence Biological Sciences Biology Body Composition Boston Breeding Capital Clinical Clinical Trials Computer Analysis Computing Methodologies Containment Core Facility Development Diagnostic tests Digestive System Disorders Disease Emerging Technologies Epithelial Equipment Experimental Designs Family suidae Fermentation Funding Future Gnotobiotic Grant Health Helicobacter Human In Vitro Individual Intake Interest Group Investments Laboratories Legal patent Libraries Logistics Maintenance Massachusetts Metabolic Metabolism Metagenomics Microbe Microbiology Mission Molecular Molecular Computations Mus Names Phenotype Physiological Physiology Preparation Process Production Productivity Publications Research Research Personnel Resources Role Sampling Services Specific qualifier value Sterility Structure System Technology Therapeutic Training Work algorithm development animal facility bacterial genome sequencing cost density experimental study host microbiome host microbiota in vivo in vivo Model member metabolic abnormality assessment microbial microbial community microbiome microbiota new technology novel operation outcome prediction pathogen programs square foot transcriptomics

项目摘要

Project Summary: The Gnotobiotics, Microbiology and Metagenomics Core (Core D), supports investigators studying functional roles of the microbiota in health and disease. Core D has supported >100 groups interested in evaluating mechanisms of action by which the host’s microbiota affects host physiologic and pathophysiologic processes. Our resources include a Microbiology Unit for microbiologic culturing, phenotyping, analysis of primary samples for microbial metabolite profiles, and develop defined consortia for functional studies, a Clinical Lab (CLIA) Unit to support microbiome-focused clinical trials, a Molecular Unit for sequence-based analyses, a Gnotobiotic (germfree) mouse facility for in vivo studies in animal models, a Metabolic Unit to support mouse metabolic cage, body composition and metabolism studies, and a Computational Unit which undertakes novel algorithmic development to evaluate longitudinal dynamics of the microbiota and assist users in experimental design for host-microbiota studies. Core D provides support to multiple academic centers in the greater Boston area.

项目概要： Gnotobiotics，微生物学和宏基因组学核心（核心D），支持研究人员研究微生物群在健康和疾病中的功能作用。核心D已经支持了超过100个感兴趣的团体，评价宿主的微生物群影响宿主生理的作用机制，病理生理过程我们的资源包括微生物培养，表型分析，原发性用于微生物代谢产物谱的样品，并为功能研究开发定义的财团，临床实验室（CLIA）支持以微生物组为重点的临床试验的单位，基于序列分析的分子单位，用于动物模型体内研究的无菌（无菌）小鼠设施，一个代谢单位，小鼠代谢笼，身体组成和代谢研究，以及计算单元，进行新的算法开发，以评估微生物群的纵向动态，用于宿主微生物群研究的实验设计。核心D为大波士顿地区的多个学术中心提供支持。