Fabrication of 3D Cardiac Patches for Myocardial Recovery
用于心肌恢复的 3D 心脏贴片的制作
基本信息
- 批准号:8184313
- 负责人:
- 金额:$ 29.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Cardiovascular disease affects 80 million people in the US and is the leading cause of death. Significant limitations of current treatments necessitate the development of novel strategies. Cardiovascular tissue engineering is an emerging field focused on the development of biological substitutes to restore, maintain, or improve tissue function. Bioengineered 3-dimensional (3D) cardiac patches can be utilized clinically at the site of a myocardial infarction, promoting increased left ventricular contractile function. This study is focused on the fabrication of 3D heart muscle, using controlled stretch to support tissue development and testing the ability of cardiac patches to augment the function of infarcted myocardium. The proposed study is divided into three components. The first part of this study is focused on defining cell culture conditions to maximize the functional performance of 3D cardiac patches. The second part is focused on developing protocols to deliver controlled stretch to the 3D cardiac patches, in order to further increase the functional performance of cardiac patches. In the third part of this project, cardiac patches fabricated using optimized cell culture conditions and conditioned using stretch, will be implanted on the surface of infarcted hearts. The ability of the cardiac patches to augment the functional performance of failing myocardium will be studied, as a function of post-injury time and patch implantation time. Successful completion of this study will result in the development of 3D cardiac patches which will be functional closer to normal mammalian heart muscle and will also provide insight into the potential applicability of the cardiac patches in supporting functional recovery of failing myocardium.
PUBLIC HEALTH RELEVANCE: Cardiovascular disorders remain a major medical challenge with an urgent need to develop novel therapeutic options. In this study, cardiac patches will be fabricated and tested as a platform to support the recovery of infracted hearts. Successful completion of this study will result in the development of platform technology and provide a novel treatment modality for heart failure patients, benefiting millions of patients around the world.
描述(由申请人提供):心血管疾病影响着美国 8000 万人,并且是导致死亡的主要原因。当前治疗的显着局限性需要开发新的策略。心血管组织工程是一个新兴领域,专注于开发生物替代品以恢复、维持或改善组织功能。生物工程三维 (3D) 心脏贴片可在临床上用于心肌梗塞部位,促进左心室收缩功能增强。这项研究的重点是 3D 心肌的制造,使用受控拉伸来支持组织发育,并测试心脏贴片增强梗塞心肌功能的能力。 拟议的研究分为三个部分。本研究的第一部分重点是定义细胞培养条件,以最大限度地提高 3D 心脏贴片的功能性能。第二部分重点是开发为 3D 心脏贴片提供受控拉伸的协议,以进一步提高心脏贴片的功能性能。在该项目的第三部分中,使用优化的细胞培养条件制造并使用拉伸调节的心脏贴片将被植入梗塞心脏的表面。将研究心脏补片增强衰竭心肌功能的能力,作为损伤后时间和补片植入时间的函数。 这项研究的成功完成将导致 3D 心脏补片的开发,其功能将更接近正常哺乳动物心肌,并且还将深入了解心脏补片在支持衰竭心肌功能恢复方面的潜在适用性。
公共卫生相关性:心血管疾病仍然是一个重大的医学挑战,迫切需要开发新的治疗方案。在这项研究中,将制造并测试心脏贴片作为支持梗塞心脏康复的平台。这项研究的成功完成将促进平台技术的发展,并为心力衰竭患者提供一种新颖的治疗方式,使全球数百万患者受益。
项目成果
期刊论文数量(0)
专著数量(0)
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RAVI Kumar BIRLA其他文献
RAVI Kumar BIRLA的其他文献
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{{ truncateString('RAVI Kumar BIRLA', 18)}}的其他基金
Fabrication of 3D Cardiac Patches for Myocardial Recovery
用于心肌恢复的 3D 心脏贴片的制作
- 批准号:
7860178 - 财政年份:2010
- 资助金额:
$ 29.7万 - 项目类别:
Fabrication of 3D Cardiac Patches for Myocardial Recovery
用于心肌恢复的 3D 心脏贴片的制作
- 批准号:
8411644 - 财政年份:2010
- 资助金额:
$ 29.7万 - 项目类别:
Fabrication of 3D Cardiac Patches for Myocardial Recovery
用于心肌恢复的 3D 心脏贴片的制作
- 批准号:
8249069 - 财政年份:2010
- 资助金额:
$ 29.7万 - 项目类别:
Fabrication of 3D Cardiac Patches for Myocardial Recovery
用于心肌恢复的 3D 心脏贴片的制作
- 批准号:
8453242 - 财政年份:2010
- 资助金额:
$ 29.7万 - 项目类别:
Fabrication of 3D Cardiac Patches for Myocardial Recovery
用于心肌恢复的 3D 心脏贴片的制作
- 批准号:
8206572 - 财政年份:2010
- 资助金额:
$ 29.7万 - 项目类别:
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