Cell Fate Determination in Fetal Testes
胎儿睾丸细胞命运的测定
基本信息
- 批准号:8264238
- 负责人:
- 金额:$ 35.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A central interest in developmental, reproductive, and stem biology is how common
precursor cells acquire instruction to differentiate into specialized cell types in various
organs. Understanding how cell fates are determined not only satisfies the curiosity on
how tissues form, but also has a great implication in controlling and manipulating the
differentiation program for tissue regeneration and therapeutical purposes. The main
goal of this proposal is to understand how fetal and adult Leydig cell lineages, the
cell types responsible for masculinization and fertility of the male, are
established. Fetal and adult Leydig celis are two distinct androgen-producing celis that
appear at different developmental stages and exhibit unique morphological and
molecular characteristics. Defects in the establishment of fetal and adult Leydig cell
populations or their ability to produce hormones have a profound impact on
differentiation of male reproductive tract, spermatogenesis, and fertility. It is therefore
essential to understand how these two Leydig celi populations arise and their
differentiation is regulated. Our preliminary results suggest that fetal and adult Leydig
cells originate from a common precursor in fetal life and the hedgehog (Hh) signaling
pathway is responsible for the separation of these two Leydig celi lineages from the
common precursor population. We therefore propose to 1) investigate the effects of
ectopic activation of the Hh in the differentiation of fetal and adult Leydig cells, 2) isolate
the putative Leydig cell precursors and examine their ability to differentiate into adult
Leydig cells, and 3) examine the contribution of Gli1-positive interstitial cells to adult
Leydig cells. This application will not only provide an insight into the biological basis of
cell fate determination in testes, but will also have clinical relevance by identifying
processes susceptible to disorders of male sexual development.
发育、生殖和茎生物学的一个核心兴趣是,
前体细胞获得指令以分化成各种类型的特化细胞。
机关了解细胞命运是如何决定的,不仅满足了人们对
组织是如何形成的,而且在控制和操纵组织方面也有很大的意义。
用于组织再生和治疗目的的分化程序。主要
这项建议的目的是了解胎儿和成人间质细胞谱系,
负责男性化和男性生育力的细胞类型是
确立了习胎儿和成人间质细胞是两种不同的产生雄激素的细胞,
出现在不同的发育阶段,并表现出独特的形态和
分子特征。胎儿和成人睾丸间质细胞建立的缺陷
人口或他们产生激素的能力对人类的健康有着深远的影响。
雄性生殖道的分化、精子发生和生育力。因此
了解这两个Leydig细胞群是如何产生的,
分化是有规律的。我们的初步结果表明,胎儿和成人Leydig
细胞起源于胎儿生命和刺猬(Hh)信号的共同前体
通路负责将这两种Leydig细胞谱系从
共同的前体人口。因此,我们建议:1)调查
Hh在胎儿和成人Leydig细胞分化中的异位激活,2)分离
假定Leydig细胞前体并检测它们分化成成体的能力
Leydig细胞,以及3)检查Gli 1阳性间质细胞对成人的贡献
睾丸间质细胞。这一应用不仅将提供一个深入了解的生物学基础,
细胞命运的决定,但也将有临床意义,通过确定
易受男性性发育障碍影响的过程。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul S. Cooke其他文献
Uterine-specific emEzh2/em deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
子宫特异性 emEzh2/em 缺失会增强基质细胞衰老并损害胎盘形成,从而导致妊娠丢失
- DOI:
10.1016/j.isci.2023.107028 - 发表时间:
2023-07-21 - 期刊:
- 影响因子:4.100
- 作者:
Vijay K. Sirohi;Theresa I. Medrano;Athilakshmi Kannan;Indrani C. Bagchi;Paul S. Cooke - 通讯作者:
Paul S. Cooke
Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesis
- DOI:
10.1007/s00441-005-1082-z - 发表时间:
2005-04-23 - 期刊:
- 影响因子:2.900
- 作者:
Denise R. Holsberger;Paul S. Cooke - 通讯作者:
Paul S. Cooke
Paul S. Cooke的其他文献
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{{ truncateString('Paul S. Cooke', 18)}}的其他基金
Steroid Hormone Pathways Regulating BPH and LUTS
调节 BPH 和 LUTS 的类固醇激素途径
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10601867 - 财政年份:2023
- 资助金额:
$ 35.96万 - 项目类别:
Estrogen receptor mediated reprogramming of prostate in BPH
BPH 中雌激素受体介导的前列腺重编程
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10224181 - 财政年份:2018
- 资助金额:
$ 35.96万 - 项目类别:
Estrogen receptor mediated reprogramming of prostate in BPH
BPH 中雌激素受体介导的前列腺重编程
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10002225 - 财政年份:2018
- 资助金额:
$ 35.96万 - 项目类别:
Role of Membrane Estrogen Receptor 1 in Uterine Epithelial Response to Estrogen
膜雌激素受体 1 在子宫上皮对雌激素反应中的作用
- 批准号:
9316253 - 财政年份:2017
- 资助金额:
$ 35.96万 - 项目类别:
Membrane estrogen receptor 1 mediation of epigenetic effects of estrogen
膜雌激素受体1介导雌激素的表观遗传效应
- 批准号:
9182526 - 财政年份:2016
- 资助金额:
$ 35.96万 - 项目类别:
Membrane estrogen receptor 1 mediation of epigenetic effects of estrogen
膜雌激素受体1介导雌激素的表观遗传效应
- 批准号:
9401825 - 财政年份:2016
- 资助金额:
$ 35.96万 - 项目类别:
DIETARY PHYTOESTROGENS AND ADIPOCYTE DEVELOPMENT
膳食植物雌激素和脂肪细胞发育
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6856238 - 财政年份:2004
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Genistein induces thymic atrophy: a health concern?
金雀异黄素会引起胸腺萎缩:健康问题吗?
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6868236 - 财政年份:2003
- 资助金额:
$ 35.96万 - 项目类别:
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