Microscopy Core

U54合作专业研究中心提案的总体目标是， 分子和细胞水平，调节胚胎植入和生育的激素途径。失败 受精胚胎植入子宫内膜是不孕的主要原因。中心将支持A 一个多学科的科学家小组，共同感兴趣的是了解机制和细胞 控制着床的通路建立这样一个中心的理由是， 鉴定异常表达或功能导致不孕的子宫内膜因子。的 要实现这一目标，就需要基础和临床之间建立一种紧密、高效的伙伴关系。 科学家们用创新的调查策略来解决这个问题。这将推动我们目前的 了解植入的分子基础，并帮助确定导致女性不孕的因素 患有子宫内膜异位症一种常见的妇科疾病从这些研究中获得的知识 还有助于开发新的分子诊断工具，用于筛查子宫内膜功能障碍， 治疗不孕症的靶向治疗策略。 该计划由四个互补的协同项目组成：（1）C/EBP Deta在子宫中的作用 蜕膜化和着床，（2）核受体辅助调节剂在着床和子宫功能中的作用，（3） BMP-2通路对间质分化和着床的调节，以及（4）子宫内膜异位症作为一种 蜕膜前功能障碍的临床模型。研究者将得到两个核心设施的帮助：核心A： 管理核心和核心B：显微镜核心。

The overall objective of this U54 Cooperative Specialized Research Center proposal is to characterize, at molecular and cellular levels, the hormonal pathways that regulate embryo implantation and fertility. Failure of the fertilized embryo to implant into the endometrium is a major cause of infertility. The Center will support a multidisciplinary group of scientists with a common interest to understand the mechanisms and cellular pathways that control implantation. The rationale for creating such a Center is to direct our concerted efforts toward the identification of endometrial factors whose aberrant expression or function leads to infertility. The achievement of this goal would require a cohesive, highly effective partnership between the basic and clinical scientists, addressing this question with innovative investigative strategies. This would advance our current understanding of the molecular basis of implantation and help identify factors that underlie infertility in women suffering from endometriosis, a common gynecologic disorder. The knowledge gained from these studies should also aid in developing new molecular diagnostic tools for screening endometrial dysfunction and enable targeted therapeutic strategies for the treatment of infertility. The program is comprised of four complementary, synergistic projects: (1) Role of C/EBP Deta in Uterine Decidualization and Implantation, (2) Nuclear Receptor Coregulators in Implantation and Uterine Function, (3) Regulation of Stromal Differentiation and Implantation by the BMP2 Pathway, and (4) Endometriosis as a Clinical Model of Predecidual Dysfunction. Investigators will be aided by two core facilities: Core A: Administrative Core, and Core B: Microscopy Core.