Microscopy Core

U54合作专门研究中心提案的总体目标是在 分子和细胞水平，即调节胚胎植入和生育的荷尔蒙途径。故障： 受精胚胎植入子宫内膜是导致不孕的主要原因。该中心将支持 一个多学科的科学家小组，他们有共同的兴趣来了解细胞的机制和 控制着床的通路。创建这样一个中心的理由是指导我们的共同努力 用于识别其异常表达或功能导致不孕不育的子宫内膜因素。这个 实现这一目标需要在基础和临床之间建立紧密、高效的伙伴关系。 科学家们，用创新的调查策略来解决这个问题。这将推进我们目前的 了解植入的分子基础并帮助确定女性不孕症的潜在因素 患有子宫内膜异位症，这是一种常见的妇科疾病。从这些研究中获得的知识 还应帮助开发筛查子宫内膜功能障碍的新分子诊断工具，并使 治疗不孕不育症的靶向治疗策略。 该方案由四个相辅相成的协同项目组成：(1)C/EBP DATA在子宫中的作用 蜕膜化与着床；(2)核受体协同调节与着床；(3)子宫功能 BMP2途径对间质分化和着床的调控；(4)子宫内膜异位症 早孕功能障碍的临床模型。调查人员将得到两个核心设施的协助：核心A： 管理核心和核心B：显微镜核心。

The overall objective of this U54 Cooperative Specialized Research Center proposal is to characterize, at molecular and cellular levels, the hormonal pathways that regulate embryo implantation and fertility. Failure of the fertilized embryo to implant into the endometrium is a major cause of infertility. The Center will support a multidisciplinary group of scientists with a common interest to understand the mechanisms and cellular pathways that control implantation. The rationale for creating such a Center is to direct our concerted efforts toward the identification of endometrial factors whose aberrant expression or function leads to infertility. The achievement of this goal would require a cohesive, highly effective partnership between the basic and clinical scientists, addressing this question with innovative investigative strategies. This would advance our current understanding of the molecular basis of implantation and help identify factors that underlie infertility in women suffering from endometriosis, a common gynecologic disorder. The knowledge gained from these studies should also aid in developing new molecular diagnostic tools for screening endometrial dysfunction and enable targeted therapeutic strategies for the treatment of infertility. The program is comprised of four complementary, synergistic projects: (1) Role of C/EBP Deta in Uterine Decidualization and Implantation, (2) Nuclear Receptor Coregulators in Implantation and Uterine Function, (3) Regulation of Stromal Differentiation and Implantation by the BMP2 Pathway, and (4) Endometriosis as a Clinical Model of Predecidual Dysfunction. Investigators will be aided by two core facilities: Core A: Administrative Core, and Core B: Microscopy Core.