Neural Crest Stem Cell Therapy for Absence of Intestinal Nerves in Hirschsprungs Disease

神经嵴干细胞疗法治疗先天性巨结肠症肠神经缺失

• 批准号: nhmrc : 546473
• 负责人: Dr Donald Newgreen
• 金额: $ 33.63万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neural-crest-stem-hirschsprungs-disease/80718
• 关键词: Neural; Crest; Stem; Cell; Therapy

Hirschsprung's disease is acommon birth defect caused by failure of nerve cells to get into the colon. This results in intractable often fatal constipation. Current treatment is surgical removal of the affected colon soon after birth but often problems persist. These nerves might be rebuilt using nerve stem cells, but not all stem cells have this capacity. And is not known if this can be achieved after birth: This project will define which stem cell populations to use and in what age of bowel.

先天性巨结肠是一种常见的先天性缺陷，是由于神经细胞无法进入结肠而引起的。这导致顽固性便秘，往往是致命的。目前的治疗方法是在出生后不久手术切除受影响的结肠，但通常问题仍然存在。这些神经可以用神经干细胞重建，但不是所有的干细胞都有这种能力。目前还不知道这是否可以在出生后实现：该项目将确定使用哪些干细胞群以及在什么年龄段的肠道中使用。