Neural Crest Stem Cell Therapy for Absence of Intestinal Nerves in Hirschsprungs Disease

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Hirschsprung's disease is acommon birth defect caused by failure of nerve cells to get into the colon. This results in intractable often fatal constipation. Current treatment is surgical removal of the affected colon soon after birth but often problems persist. These nerves might be rebuilt using nerve stem cells, but not all stem cells have this capacity. And is not known if this can be achieved after birth: This project will define which stem cell populations to use and in what age of bowel.