Can human neural stem cells form enteric nerves in human Hirschsprungs Disease colon?

人类神经干细胞能否在人类先天性巨结肠中形成肠神经？

• 批准号: nhmrc : 607380
• 负责人: Dr Donald Newgreen
• 金额: $ 39.93万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/human-neural-stem-disease-colon/77121
• 关键词: human; neural; stem; cells; form

The intestine has its own nervous system which develops from cells that migrate into the intestine during early development. Sometimes this does not work and part of the bowel has no nerves and cannot function. This is treated now by cutting out this bad bowel and joining the sections of good bowel. But it may be possible to grow new nerves in the bad bowel using stem cells. This project aims to test whether this treatment, which would avoid loss of bowel, is possible.

肠道有自己的神经系统，在发育早期由迁移到肠道的细胞发育而来。有时这样做不起作用，部分肠道没有神经，不能发挥作用。现在的治疗方法是切除这个坏的肠段，然后把好肠段连接起来。但是，使用干细胞在不良肠道中长出新的神经是可能的。该项目旨在测试这种避免肠道丢失的治疗方法是否可行。