Genetic Basis of Inflammatory Airway Disease

炎症性气道疾病的遗传基础

• 批准号: 7664316
• 负责人: Francis Sessions Cole
• 金额: $ 39.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664316
• 关键词: Arts; Asthma; Biological; Biometry; Chronic Obstructive Airway Disease; Complex; Cystic Fibrosis; Disease; Educational Curriculum; Effectiveness; Environment; Faculty; Family; Genetic; Genomics; Immersion Investigative Technique; Inflammatory; Investigation; Journals; K-Series Research Career Programs; Leadership; Lung; Lung diseases; Manuscripts; Master of Science; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; National Heart, Lung, and Blood Institute; Publications; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Therapeutic; Training; Training Programs; Translational Research; Travel; Universities; Washington; abstracting; airway inflammation; base; career development; experience; genetic epidemiology; lectures; multidisciplinary; novel diagnostics; programs; success; symposium

DESCRIPTION (provided by applicant): The objectives of this Career Development Program in the Genetics and Genomics of Lung Diseases entitled "Genetic Basis of Inflammatory Airway Disease" are to develop and evaluate a multidisciplinary program that will educate young pulmonary investigators in methods of genetics and genomics to become independent investigators and assume leadership roles in the genetics and genomics of pulmonary diseases. The central focus of this program, inflammatory airway disease, including asthma, cystic fibrosis, and chronic obstructive pulmonary disease, reflects the importance of understanding diverse, complex pulmonary diseases characterized by airway inflammation and exploits the strong commitment of the faculty at Washington University to apply methods in genetics and genomics to investigation of the biological basis of this family of lung diseases. The first year curriculum will include: 1) the established Genetic Epidemiology Masters of Science (GEMS) Training Program sponsored by the Division of Biostatistics; 2) a mentored research experience to insure submission of a manuscript for publication by the summer of the second year; 3) 3 month educational immersion experiences with established pulmonary and genomic teams of investigators; 4) relevant, ongoing conferences, journal clubs, lectures, and courses; and, 5) the NHLBI sponsored Programs for Genomic Applications Traveling Tutorial. The second and third year curriculum will include: 1) continuation of the mentored research experience; 2) additional courses; and, 3) submission of a K Award application. The specific aims of this application include: Specific Aim (1): We will provide fundamental training in genetic epidemiology and biostatistics with emphasis on translational research. Specific Aim (2): We will provide extensive mentoring to the trainees for career development and for developing independent research plans that focus on pulmonary disorders. Specific Aim (3): We will support trainees by helping them prepare independent career development research grants such as KO8 and K23 Awards and by taking full advantage of the extraordinary resources of the participating mentors and institutional environment. Specific Aim (4): We will develop and implement plans for evaluating and tracking the effectiveness and success of these efforts for each trainee up to 2 years after completion of the program. This career development program will train young scientists to use state of the art methods in genetics and genomics to develop new diagnostic and therapeutic strategies for asthma, cystic fibrosis, and COPD. (End of Abstract)

描述（由申请人提供）： 该职业发展计划在肺部疾病的遗传学和基因组学方面的目标是“炎症性气道疾病的遗传基础”的目标，是开发和评估一项多学科计划，该计划将教育年轻的肺肺部研究人员，以遗传和基因组方法成为独立研究者，并在遗传学和原型疾病的遗传学和原型疾病中发挥领导作用。该计划的主要重点是炎症性气道疾病，包括哮喘，囊性纤维化和慢性阻塞性肺部疾病，反映了理解多样的，复杂的肺部疾病的重要性，这些疾病的特征是气道炎症，并利用了华盛顿大学在遗传学和模型基础上将教师的强烈承诺应用于该家族的基础。第一年的课程将包括：1）由生物统计学部门赞助的已建立的遗传流行病学硕士（GEMS）培训计划； 2）有指导的研究经验，以确保在第二年夏天提交手稿出版； 3）与已建立的肺和基因组研究人员团队的3个月教育沉浸体验； 4）相关的，正在进行的会议，期刊俱乐部，讲座和课程； 5）NHLBI赞助了用于旅行教程的基因组应用程序。第二年和第三年的课程将包括：1）延续指导的研究经验； 2）其他课程； 3）提交K奖励申请。该应用程序的具体目的包括：具体目的（1）：我们将提供遗传流行病学和生物统计学的基本培训，重点是转化研究。 具体目标（2）：我们将为受训者提供广泛的指导，以进行职业发展以及制定关注肺部疾病的独立研究计划。 具体目标（3）：我们将通过帮助学员准备独立的职业发展研究补助金，例如KO8和K23奖项，并充分利用参与导师和机构环境的非凡资源。 具体目标（4）：我们将制定和实施计划，以评估和跟踪计划完成后2年的每个学员对这些努力的有效性和成功。这项职业发展计划将培训年轻科学家在遗传学和基因组学领域使用最先进的方法来开发哮喘，囊性纤维化和COPD的新诊断和治疗策略。 （抽象的结尾）