Genetic Basis of Inflammatory Airway Disease

炎症性气道疾病的遗传基础

• 批准号: 7664316
• 负责人: Francis Sessions Cole
• 金额: $ 39.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-27 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7664316
• 关键词: Arts; Asthma; Biological; Biometry; Chronic Obstructive Airway Disease; Complex; Cystic Fibrosis; Disease; Educational Curriculum; Effectiveness; Environment; Faculty; Family; Genetic; Genomics; Immersion Investigative Technique; Inflammatory; Investigation; Journals; K-Series Research Career Programs; Leadership; Lung; Lung diseases; Manuscripts; Master of Science; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; National Heart, Lung, and Blood Institute; Publications; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Therapeutic; Training; Training Programs; Translational Research; Travel; Universities; Washington; abstracting; airway inflammation; base; career development; experience; genetic epidemiology; lectures; multidisciplinary; novel diagnostics; programs; success; symposium

DESCRIPTION (provided by applicant): The objectives of this Career Development Program in the Genetics and Genomics of Lung Diseases entitled "Genetic Basis of Inflammatory Airway Disease" are to develop and evaluate a multidisciplinary program that will educate young pulmonary investigators in methods of genetics and genomics to become independent investigators and assume leadership roles in the genetics and genomics of pulmonary diseases. The central focus of this program, inflammatory airway disease, including asthma, cystic fibrosis, and chronic obstructive pulmonary disease, reflects the importance of understanding diverse, complex pulmonary diseases characterized by airway inflammation and exploits the strong commitment of the faculty at Washington University to apply methods in genetics and genomics to investigation of the biological basis of this family of lung diseases. The first year curriculum will include: 1) the established Genetic Epidemiology Masters of Science (GEMS) Training Program sponsored by the Division of Biostatistics; 2) a mentored research experience to insure submission of a manuscript for publication by the summer of the second year; 3) 3 month educational immersion experiences with established pulmonary and genomic teams of investigators; 4) relevant, ongoing conferences, journal clubs, lectures, and courses; and, 5) the NHLBI sponsored Programs for Genomic Applications Traveling Tutorial. The second and third year curriculum will include: 1) continuation of the mentored research experience; 2) additional courses; and, 3) submission of a K Award application. The specific aims of this application include: Specific Aim (1): We will provide fundamental training in genetic epidemiology and biostatistics with emphasis on translational research. Specific Aim (2): We will provide extensive mentoring to the trainees for career development and for developing independent research plans that focus on pulmonary disorders. Specific Aim (3): We will support trainees by helping them prepare independent career development research grants such as KO8 and K23 Awards and by taking full advantage of the extraordinary resources of the participating mentors and institutional environment. Specific Aim (4): We will develop and implement plans for evaluating and tracking the effectiveness and success of these efforts for each trainee up to 2 years after completion of the program. This career development program will train young scientists to use state of the art methods in genetics and genomics to develop new diagnostic and therapeutic strategies for asthma, cystic fibrosis, and COPD. (End of Abstract)

描述（由申请人提供）： 这个职业发展计划在肺部疾病的遗传学和基因组学题为“炎症性气道疾病的遗传基础”的目标是开发和评估一个多学科的计划，将教育年轻的肺部研究者在遗传学和基因组学的方法，成为独立的研究者，并承担领导作用的遗传学和基因组学的肺部疾病。该项目的中心焦点是炎症性气道疾病，包括哮喘、囊性纤维化和慢性阻塞性肺病，反映了理解以气道炎症为特征的多种复杂肺部疾病的重要性，并利用了华盛顿大学教师的坚定承诺，将遗传学和基因组学方法应用于调查该家族肺部疾病的生物学基础。第一年的课程将包括：1）由生物统计学部赞助的已建立的遗传流行病学科学硕士（GEMS）培训计划; 2）指导研究经验，以确保在第二年夏天提交手稿供出版; 3）与已建立的肺部和基因组研究团队一起进行为期3个月的教育沉浸体验; 4）相关的，正在进行的会议，期刊俱乐部，讲座和课程;以及，5）NHLBI赞助的基因组应用程序旅行计划。第二年和第三年的课程将包括：1）继续指导研究经验; 2）额外的课程;以及，3）提交K奖申请。本申请的具体目标包括：具体目标（1）：我们将提供遗传流行病学和生物统计学的基础培训，重点是转化研究。 具体目标（二）：我们将为学员提供广泛的职业发展指导，并制定专注于肺部疾病的独立研究计划。 具体目标（三）：我们将通过帮助学员准备独立的职业发展研究赠款，如KO 8和K23奖，并充分利用参与导师和机构环境的非凡资源来支持学员。 具体目标（四）：我们将制定和实施计划，以评估和跟踪这些努力的有效性和成功，为每个学员长达2年后完成的计划。该职业发展计划将培训年轻科学家使用遗传学和基因组学的最新方法来开发哮喘，囊性纤维化和COPD的新诊断和治疗策略。 (End摘要）