Air Pollution, Stress and Asthma Morbidity Risk: Role of Biological and Geospatial Markers

项目概要/摘要 候选人：Marissa Hauptman 博士是哈佛医学院 (HMS) 儿科讲师， 儿科医生和环境医学毒理学家，以及儿科环境助理主任 波士顿儿童医院 (BCH) 健康中心。在 BCH，她完成了儿科住院医师实习和联合实习 儿科环境医学和健康服务研究金。在她早期工作的基础上，她 拟议的职业发展计划重点关注两个职业发展领域——地理空间和生物标记 环境暴露科学、临床生物医学信息学——这将增加她的研究工具包，增加 工作的严谨性，并增强她开发、评估和整合环境暴露的能力 科学和流行病学进入临床医学。她将通过课程、体验获得这些技能 学习、指导和参加研讨会以及国内和国际会议。环境：博士。 Hauptman 得到了 BCH、HMS 和 HMS 的广泛研究、专业和学术资源的支持。 哈佛大学 T.H.陈公共卫生学院，包括 BCH 临床和临床研究机构中心 转化研究、Harvard-Chan NIEHS 环境健康中心和哈佛催化剂 计划。她忠诚的导师和顾问团队包括地理空间、空气污染和 生物标志物环境暴露科学和流行病学、生物统计学/生物信息学和临床 预测方法。研究：尽管越来越多的证据表明空气污染有其不利影响，但它并没有 临床医学领域的医疗保健提供者已有效解决了这一问题。显然需要进一步的知识， 阐明强大的环境空气污染物生物标志物和现成的地理空间数据以及 潜在的机制可能会为临床医生带来新的治疗选择和策略，以更好地解决这一问题 患者的床边环境。 Hauptman 博士建议以之前的工作为基础，严格评估和 开发——通过地理空间和生物标记环境暴露科学、流行病学和生物医学 信息学——一种可行的创新哮喘综合风险 (AIR) 临床预测模型，依赖于容易 通过患者报告、电子病历系统、公共可用数据源和 生物标志物可以帮助临床医生预测患有哮喘的高风险儿科患者，并可能 定制环境和治疗干预措施。在这个项目结束时，豪普特曼博士将很好地—— 定位申请R01以进一步测试该临床决策的实施是否支持 干预措施通过更全面地识别和解决环境空气问题来改善哮喘发病率 患有慢性健康问题的儿童的污染物。该项目的成功完成将为博士奠定基础。 豪普特曼作为一名解决环境暴露问题的独立调查员，为她职业生涯的下一阶段做准备 在临床医学中。

PROJECT SUMMARY / ABSTRACT Candidate: Dr. Marissa Hauptman is an Instructor of Pediatrics at Harvard Medical School (HMS), a pediatrician and environmental medical toxicologist, and Assistant Director of the Pediatric Environmental Health Center at Boston Children’s Hospital (BCH). At BCH, she completed her pediatrics residency and a joint pediatric environmental medicine and health services research fellowship. Building on her early work, her proposed career development plan focuses on 2 areas of career development—geospatial and biomarker environmental exposure science, clinical biomedical informatics—that will add to her research toolkit, increase the rigor of her work, and enhance her ability to develop, evaluate, and integrate environmental exposure science and epidemiology into clinical medicine. She will gain these skills through coursework, experiential learning, mentorship, and participation in seminars and national and international meetings. Environment: Dr. Hauptman is supported by extensive research, professional, and academic resources at BCH, HMS, and Harvard T.H. Chan School of Public Health, including the BCH Institutional Centers for Clinical and Translational Research, Harvard-Chan NIEHS Center on Environmental Health, and the Harvard Catalyst Program. Her committed team of mentors and advisors include national experts in geospatial, air pollution and biomarker environmental exposure science and epidemiology, biostatistics/bioinformatics and clinical prediction methodology. Research: Despite increasing evidence of its adverse effects, air pollution has not been effectively addressed by healthcare providers in clinical medicine. Further knowledge is clearly needed, as elucidating robust environmental air pollutant biomarkers and readily available geospatial data as well as underlying mechanisms may lead to new therapeutic options and strategies for clinicians to better address a patient’s environment at the bedside. Dr. Hauptman proposes to build on prior work to rigorously evaluate and develop—through geospatial and biomarker environmental exposure science, epidemiology, and biomedical informatics—a feasible innovative Asthma Integrated Risk (AIR) Clinical Prediction model that relies on readily available data through patient report, the electronic medical record system, public available data sources and biomarkers that can assist clinicians in predicting high risk pediatric patients with asthma and potentially tailoring environmental and therapeutic interventions. At the end of this project, Dr. Hauptman will be well- positioned to apply for an R01 to further test whether implementation of this clinical decision support intervention improves asthma morbidity by more comprehensively identifying and addressing environmental air pollutants in children with chronic health conditions. The successful completion of this project will position Dr. Hauptman for the next stage of her career as an independent investigator addressing environmental exposures in clinical medicine.