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Air Pollution, Stress and Asthma Morbidity Risk: Role of Biological and Geospatial Markers

空气污染、压力和哮喘发病风险：生物和地理空间标记的作用

基本信息

批准号：
10396626
负责人：
Marissa Hauptman
金额：
$ 19.71万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10396626
关键词：
Active Learning Address Adverse effects Air Pollutants Air Pollution Area Aromatic Polycyclic Hydrocarbons Asthma Bioinformatics Biological Biological Markers Biometry Boston Caring Characteristics Child Childhood Childhood Asthma Chronic Chronic Disease Clinical Clinical Medicine Clinical Research Computerized Medical Record Dangerousness Data Data Sources Development Plans Disease Electronic Health Record Environment Environmental Air Pollutants Environmental Epidemiology Environmental Exposure Environmental Health Environmental Medicine Environmental Pollutants Environmental Risk Factor Epidemiology Exposure to Family Fellowship Foundations Funding Future Goals Guidelines Health Health Personnel Health Professional Health Services Research Housing Immunologics Individual Institutional Review Boards International Intervention Joints Knowledge Lead Measures Medical Mentors Mentorship Methodology Morbidity - disease rate National Institute of Environmental Health Sciences Outcomes Research Patients Pediatric Hospitals Pediatrics Physicians Play Pollution Population Positioning Attribute Predisposition Public Health Schools Reporting Research Research Personnel Research Project Grants Residencies Resources Risk Risk Factors Role Schools Science Scientist Stress Subgroup System Testing Therapeutic Therapeutic Intervention Time Training Translational Research United States National Institutes of Health Work asthma model asthmatic patient biomedical informatics career career development catalyst clinical care clinical center clinical decision support clinical decision-making clinical implementation clinical risk cohort community-level factor data repository environmental intervention environmental stressor experience health disparity high risk improved inner city innovation instructor medical schools meetings novel novel therapeutics patient population pediatric patients pediatrician pollutant predictive modeling preventive intervention programs skills social social determinants social stressor tool traffic-related air pollution urinary

项目摘要

PROJECT SUMMARY / ABSTRACT Candidate: Dr. Marissa Hauptman is an Instructor of Pediatrics at Harvard Medical School (HMS), a pediatrician and environmental medical toxicologist, and Assistant Director of the Pediatric Environmental Health Center at Boston Children’s Hospital (BCH). At BCH, she completed her pediatrics residency and a joint pediatric environmental medicine and health services research fellowship. Building on her early work, her proposed career development plan focuses on 2 areas of career development—geospatial and biomarker environmental exposure science, clinical biomedical informatics—that will add to her research toolkit, increase the rigor of her work, and enhance her ability to develop, evaluate, and integrate environmental exposure science and epidemiology into clinical medicine. She will gain these skills through coursework, experiential learning, mentorship, and participation in seminars and national and international meetings. Environment: Dr. Hauptman is supported by extensive research, professional, and academic resources at BCH, HMS, and Harvard T.H. Chan School of Public Health, including the BCH Institutional Centers for Clinical and Translational Research, Harvard-Chan NIEHS Center on Environmental Health, and the Harvard Catalyst Program. Her committed team of mentors and advisors include national experts in geospatial, air pollution and biomarker environmental exposure science and epidemiology, biostatistics/bioinformatics and clinical prediction methodology. Research: Despite increasing evidence of its adverse effects, air pollution has not been effectively addressed by healthcare providers in clinical medicine. Further knowledge is clearly needed, as elucidating robust environmental air pollutant biomarkers and readily available geospatial data as well as underlying mechanisms may lead to new therapeutic options and strategies for clinicians to better address a patient’s environment at the bedside. Dr. Hauptman proposes to build on prior work to rigorously evaluate and develop—through geospatial and biomarker environmental exposure science, epidemiology, and biomedical informatics—a feasible innovative Asthma Integrated Risk (AIR) Clinical Prediction model that relies on readily available data through patient report, the electronic medical record system, public available data sources and biomarkers that can assist clinicians in predicting high risk pediatric patients with asthma and potentially tailoring environmental and therapeutic interventions. At the end of this project, Dr. Hauptman will be well- positioned to apply for an R01 to further test whether implementation of this clinical decision support intervention improves asthma morbidity by more comprehensively identifying and addressing environmental air pollutants in children with chronic health conditions. The successful completion of this project will position Dr. Hauptman for the next stage of her career as an independent investigator addressing environmental exposures in clinical medicine.

项目摘要/摘要