Genetic Basis of Inflammatory Airway Disease

描述（由申请人提供）： 这项名为“炎症性气道疾病的遗传学基础”的肺部疾病遗传学和基因组学职业发展计划的目标是开发和评估一个多学科计划，该计划将教育年轻的肺部研究人员掌握遗传学和基因组学的方法，使其成为独立的研究人员，并在肺部疾病的遗传学和基因组学方面发挥领导作用。该项目的中心焦点是炎症性气道疾病，包括哮喘、囊性纤维化和慢性阻塞性肺病，反映了了解以气道炎症为特征的多种复杂肺部疾病的重要性，并利用了华盛顿大学教师的坚定承诺，应用遗传学和基因组学方法来研究该肺部疾病家族的生物学基础。第一年的课程将包括： 1）由生物统计处资助设立的遗传流行病学理学硕士（GEMS）培训项目； 2) 受指导的研究经验，以确保在第二年夏天提交稿件以供出版； 3) 与已建立的肺部和基因组研究团队一起进行 3 个月的沉浸式教育体验； 4) 相关的、正在进行的会议、期刊俱乐部、讲座和课程； 5) NHLBI 赞助的基因组应用旅行教程项目。第二年和第三年的课程将包括：1）继续指导研究经验； 2）附加课程； 3) 提交 K 奖申请。本申请的具体目标包括： 具体目标（1）：我们将提供遗传流行病学和生物统计学方面的基础培训，重点是转化研究。 具体目标 (2)：我们将为学员提供广泛的职业发展指导，并制定专注于肺部疾病的独立研究计划。 具体目标（3）：我们将帮助学员准备独立的职业发展研究资助，如KO8和K23奖，并充分利用参训导师的非凡资源和机构环境，为学员提供支持。 具体目标 (4)：我们将制定并实施计划，以评估和跟踪每位学员在项目完成后 2 年内这些努力的有效性和成功情况。该职业发展计划将培训年轻科学家使用最先进的遗传学和基因组学方法来开发哮喘、囊性纤维化和慢性阻塞性肺病的新诊断和治疗策略。 （摘要完）

DESCRIPTION (provided by applicant): The objectives of this Career Development Program in the Genetics and Genomics of Lung Diseases entitled "Genetic Basis of Inflammatory Airway Disease" are to develop and evaluate a multidisciplinary program that will educate young pulmonary investigators in methods of genetics and genomics to become independent investigators and assume leadership roles in the genetics and genomics of pulmonary diseases. The central focus of this program, inflammatory airway disease, including asthma, cystic fibrosis, and chronic obstructive pulmonary disease, reflects the importance of understanding diverse, complex pulmonary diseases characterized by airway inflammation and exploits the strong commitment of the faculty at Washington University to apply methods in genetics and genomics to investigation of the biological basis of this family of lung diseases. The first year curriculum will include: 1) the established Genetic Epidemiology Masters of Science (GEMS) Training Program sponsored by the Division of Biostatistics; 2) a mentored research experience to insure submission of a manuscript for publication by the summer of the second year; 3) 3 month educational immersion experiences with established pulmonary and genomic teams of investigators; 4) relevant, ongoing conferences, journal clubs, lectures, and courses; and, 5) the NHLBI sponsored Programs for Genomic Applications Traveling Tutorial. The second and third year curriculum will include: 1) continuation of the mentored research experience; 2) additional courses; and, 3) submission of a K Award application. The specific aims of this application include: Specific Aim (1): We will provide fundamental training in genetic epidemiology and biostatistics with emphasis on translational research. Specific Aim (2): We will provide extensive mentoring to the trainees for career development and for developing independent research plans that focus on pulmonary disorders. Specific Aim (3): We will support trainees by helping them prepare independent career development research grants such as KO8 and K23 Awards and by taking full advantage of the extraordinary resources of the participating mentors and institutional environment. Specific Aim (4): We will develop and implement plans for evaluating and tracking the effectiveness and success of these efforts for each trainee up to 2 years after completion of the program. This career development program will train young scientists to use state of the art methods in genetics and genomics to develop new diagnostic and therapeutic strategies for asthma, cystic fibrosis, and COPD. (End of Abstract)