CD8 Tau cell contraction and memory formation
CD8 Tau cell contraction and memory formation
批准号:
8282722
负责人:
Martin Prlic
金额:
$24.59万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-08-01 至 2013-09-30
关键词:
AcuteAddressAffectAffinityAgreementAntibody FormationAntigensApplications GrantsAutophagocytosisAwardB-LymphocytesBacteriaBiological ModelsBlood specimenCD8B1 geneCaspaseCell CountCell DeathCell SurvivalCellsControl GroupsCuesCytotoxic T-LymphocytesDataDendritic CellsDistalEffector CellEpitopesFrequenciesGenesGoalsGrantGranzymeHIVHourImmune systemImmunityIn VitroInfectionInflammationInflammatoryKnockout MiceLeadLifeLightListeria monocytogenesLongevityMHC Class I GenesMalariaManuscriptsMature T-LymphocyteMediatingMemoryMolecularMouse StrainsMusOVA-8OvalbuminOvaryPathway interactionsPhasePhenotypePhysiologic pulsePopulationProcessProgress ReportsProliferatingPropertyPublicationsPublished CommentPublishingReadingRecombinantsRegimenReporterResearchResearch ProposalsRoleSeriesSignal PathwaySpottingsStagingStaining methodStainsStem cellsStimulusT cell responseT memory cellT-Cell ActivationT-Cell DevelopmentT-LymphocyteTestingThymus GlandTimeTransgenic MiceTuberculosisUpdateVaccinationVaccinesVacciniaVacciniumVesicular stomatitis Indiana virusVirusVirus DiseasesWorkbasebeta cateninfitnessfollow-upimprintimprovedin vivoinsightknock-downmemory recalloverexpressionpathogenprogramspromoterresearch studyresponsetau Proteinstranscription factortransgene expressiontumorvaccination strategy
中文摘要
免疫系统的适应性分支由B淋巴细胞和T淋巴细胞组成。CD8 T细胞是关键
英文摘要
The adaptive branch of the immune system consists of B and T lymphocytes. CD8 T cells are key
players in mediating immunity to Intracellular pathogens and tumors. CDS T cells that encounter antigen in
the context of MHC class I become activated and initiate a program of proliferation and differentiation into
effector cytotoxic T lymphocytes (CTL). Typically, in response to an acute viral infection, a naive CDS T cell
may go through more than 15 divisions in 6 days to generate thousands of effector progeny. At the peak of
this response, also called the primary response, antigen has typically been cleared and in the following days
more than 90% of the effector CDS T cells die. This process called contraction leaves behind a surviving
fraction of T cells that persists as long-lived memory cells. Apart from their longevity, memory cells are
further characterized by their ability to respond with enhanced efficacy to rechallenge with the same antigen
(secondary response). These features, plus their increased numbers, allow memory CD8+ T cell to provide
efficient long lasting immunity against previously encountered pathogens.
While many established vaccination programs are mainly dependent on an efficient antibody response,
cun^ent challenges such as malaria, HIV and tuberculosis appear to require a different approach. CDS T
cells are a key player protecting us against intracellular pathogens (such as viruses or certain intracellular
bacteria). A thorough understanding of how CDS T cell memory is generated and maintained will provide us
with more insight and better vaccination strategies.
We want to focus our research on the poorly understood contraction part of the CDS T cell response.
The broad goal of my research is to understand how the transition of CDS T cells from the effector to the
memory stage is regulated and how a fit memory T cell pool is generated. The more specific goal for the
next two years is to shed light on the mechanisms that control certain aspects of the contraction phase and
the ensuing memory phase of the CDS T cell response.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.4049/jimmunol.1302289
发表时间:
2014-01-01
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
[Zehn D, Roepke S, Weakly K, Bevan MJ, Prlic M]
通讯作者:
Prlic M
Single-Cell Analysis To Define Protective and Tolerizing Immune Cell Populations in the Human Placenta
-
批准号:9978484
-
项目类别:
-
资助金额:$28.33万
-
财政年份:2020
-
负责人:Martin Prlic
-
依托单位:
Single-Cell Analysis To Define Protective and Tolerizing Immune Cell Populations in the Human Placenta
-
批准号:10594099
-
项目类别:
-
资助金额:$12.94万
-
财政年份:2020
-
负责人:Martin Prlic
-
依托单位:
Single-Cell Analysis To Define Protective and Tolerizing Immune Cell Populations in the Human Placenta
-
批准号:10401230
-
项目类别:
-
资助金额:$6.39万
-
财政年份:2020
-
负责人:Martin Prlic
-
依托单位:
Inflammation-driven T Cell Responses and their Dichotomous Effect on Host Immunity
-
批准号:10593467
-
项目类别:
-
资助金额:$16.68万
-
财政年份:2016
-
负责人:Martin Prlic
-
依托单位:
Inflammation-driven T Cell Responses and their Dichotomous Effect on Host Immunity
-
批准号:10058804
-
项目类别:
-
资助金额:$27.32万
-
财政年份:2016
-
负责人:Martin Prlic
-
依托单位:
Inflammation-driven T Cell Responses and their Dichotomous Effect on Host Immunity
-
批准号:10682491
-
项目类别:
-
资助金额:$52.8万
-
财政年份:2016
-
负责人:Martin Prlic
-
依托单位:
Paving the Way for a Novel Therapeutic Approach to Combat HIV
-
批准号:8358310
-
项目类别:
-
资助金额:$264.0万
-
财政年份:2012
-
负责人:Martin Prlic
-
依托单位:
CD8 Tau cell contraction and memory formation
-
批准号:7660600
-
项目类别:
-
资助金额:$9.0万
-
财政年份:2009
-
负责人:Martin Prlic
-
依托单位:
CD8 Tau cell contraction and memory formation
-
批准号:8210398
-
项目类别:
-
资助金额:$24.9万
-
财政年份:2009
-
负责人:Martin Prlic
-
依托单位:
海外基金