Training in emerging infectious diseases

新发传染病培训

• 批准号: 8301668
• 负责人: Robert W. Doms
• 金额: $ 23.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301668
• 关键词: Emerging Communicable Diseases; Training

In response to increased concern about emerging and re-emerging infectious diseases, particularly Class A-C agents that could be used as weapons of bioterrorism, the microbiology community at the University of Pennsylvania proposes to establish a Training Program in Emerging Infectious Diseases. The Training Program would initially support two Ph.D. and two M.D./Ph.D. or V.M.D./Ph.D. predoctoral fellows as well as three postdoctoral fellows, enabling them to work in any one of 14 laboratories directed by principle investigators who study important viral or parasitic pathogens that are classified as either emerging or re- emerging threats to human health. The trainers associated with this T32 proposal have been selected because their research programs in these areas are well established, being supported by NIH grants and/or having published papers on this topic. The trainers study a number of important viral and parasitic pathogens. Six of the trainers on this grant study smallpox proteins or are developing anti-vaccinia agents, and currently hold 1 R01, 2 R21 and 1 U01 grants to support work in this area (Isaacs, Rosengard, Cohen, Eisenberg, Friedman, Ricciardi). Four trainers on this grant study Ebola virus, holding 1 R01 and 2 R21 grants and having published several papers in the last two years (Bates, DoTs, Shen, Harty). Collaborations with colleagues at USAMRIID make it possible to perform experiments with live Ebola virus. Other important emerging viral diseases that are subjects of significant research efforts by the trainers include West Nile virus and Dengue (DoTs, Bates). Emerging and re-emerging parasitic diseases are the focus of research efforts by the trainers include Malaria, a major focus of the Roos laboratory which plays a major role in managing the Plasmodium genome project. Outbreaks of leishmaniasis (Scott) in Afghan refugee camps in Pakistan and other regions, have demonstrated increased incidence of old infections from a confluence of wars, population shifts, and development into little populated regions. Due to climactic changes and large-scale water resources development projects, there have been notable new outbreaks of schistosomiasis in previously unaffected areas (Pearce, Shen). Increased infections due to toxoplasma gondii have also been reported (Roos, Hunter). With time, we anticipate that other Penn investigators will join this training program as they shift their research focus to include emerging infectious diseases. The research opportunities provided by the trainers coupled with strong institutional commitment and an extensive and well organized training program will provide excellent training in emerging infectious diseases to students and postdoctoral fellows.

为应对对新发和再发传染病的日益关注，特别是A-C类 可以被用作生物恐怖主义武器的制剂， 宾夕法尼亚州建议建立一个新出现的传染病培训计划。培训 该计划最初将支持两个博士学位。两个MD/博士或V.M.D./博士博士前研究员 作为三名博士后研究员，使他们能够在原则指导的14个实验室中的任何一个工作， 研究重要的病毒或寄生虫病原体的调查人员，这些病原体被归类为新发或复发。 对人类健康的新威胁。选择与本T32提案相关的培训师是因为 他们在这些领域的研究计划已经建立，得到了NIH赠款和/或 发表了关于这个主题的论文。培训员研究一些重要的病毒和寄生虫病原体。六 这项资助的培训人员研究天花蛋白或正在开发抗牛痘剂，目前拥有1名 R 01、2个R21和1个U 01赠款，用于支持这一领域的工作（Isaacs、Rosengard、Cohen、Eisenberg、 Friedman，Ricciardi）.该赠款的四名培训员研究埃博拉病毒，持有1份R 01和2份R21赠款， 在过去的两年里发表了几篇论文（贝茨，DoTs，沈，哈蒂）。合作与 USAMRIID的同事们使用活的埃博拉病毒进行实验成为可能。其他重要 新出现的病毒性疾病是训练人员进行重要研究的课题，其中包括西尼罗河病毒 和登革热（DOT，贝茨）。新出现和重新出现的寄生虫病是研究工作的重点， 培训人员包括疟疾，这是鲁什实验室的一个主要重点，该实验室在管理疟疾方面发挥着重要作用。 疟原虫基因组计划。巴基斯坦的阿富汗难民营爆发利什曼病（斯科特）， 在其他地区，由于战争、人口、 转移和发展到人口稀少的地区。由于气候变化和大规模的水 资源开发项目，有值得注意的新的血吸虫病爆发， 未受影响的区域（皮尔斯，沈）。由于弓形虫感染的增加也有报道 (Roos Hunter）。随着时间的推移，我们预计其他宾夕法尼亚大学的调查人员将加入这个培训计划，因为他们 将研究重点转移到新兴传染病上。提供的研究机会 培训人员，加上强有力的机构承诺和广泛和组织良好的培训计划 将为学生和博士后研究员提供新出现的传染病方面的优秀培训。