Regulation of the Warburg Effect in Cancer

癌症中瓦尔堡效应的调节

• 批准号: 8146230
• 负责人: Heather Christofk
• 金额: $ 231万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146230
• 关键词: Address; Antineoplastic Agents; Drug Delivery Systems; Maintenance; Malignant Neoplasms; Metabolism; Molecular; Normal Cell; Oxidative Phosphorylation; Oxygen; Production; Regulation; Research; Role; Testing; Therapeutic; Warburg Effect; abstracting; aerobic glycolysis; cancer cell; cancer therapy; in vivo; neoplastic cell; novel; public health relevance; tumor growth; tumorigenesis

DESCRIPTION (Provided by the applicant) Abstract: The metabolism of cancer cells is different from that of their normal cell counterparts. Known as the Warburg effect (or aerobic glycolysis), this altered tumor cell metabolism is characterized by enhanced lactate production with reduced oxidative phosphorylation even in the presence of oxygen. Although this observation was first made over 75 years ago, how cancer cells establish this altered metabolism and whether it is important for tumorigenesis remains unknown. Our research aims to determine the molecular mechanisms by which tumor cells establish and maintain the Warburg effect in cancer, to definitively address whether the Warburg effect is necessary for tumor growth, and to identify novel cancer drug targets responsible for maintenance of the Warburg effect in vivo. This study will determine whether targeting cancer metabolism is a viable approach for cancer therapy and will better define the role of metabolism for tumor growth. Public Health Relevance: This proposed research will investigate causes of the altered metabolism found in cancer cells. It will also test whether targeting this altered metabolism is a viable strategy for cancer therapeutics.

描述（由申请人提供） 翻译后摘要：癌细胞的代谢是不同的，从他们的正常细胞对应。这种改变的肿瘤细胞代谢被称为瓦尔堡效应（或有氧糖酵解），其特征在于即使在氧气存在下，乳酸产生也会增加，氧化磷酸化也会减少。尽管这一观察是在75年前首次进行的，但癌细胞如何建立这种改变的代谢以及它对肿瘤发生是否重要仍然是未知的。我们的研究旨在确定肿瘤细胞在癌症中建立和维持瓦尔堡效应的分子机制，以明确瓦尔堡效应是否是肿瘤生长所必需的，并确定负责维持体内瓦尔堡效应的新型癌症药物靶点。这项研究将确定靶向癌症代谢是否是一种可行的癌症治疗方法，并将更好地定义代谢对肿瘤生长的作用。 公共卫生相关性：这项拟议的研究将调查癌细胞中发现的代谢改变的原因。它还将测试靶向这种改变的代谢是否是癌症治疗的可行策略。