Neural signatures of disease spread and evolution in motor neurodegenerative syndromes

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A lack of understanding of the earliest changes brought on by motor neurone disease (MND), otherwise known as amyotrophic lateral sclerosis (ALS), prevents early diagnosis and therapeutic intervention. The proposed project aims to comprehensively characterise neurological changes prior to disease onset in pre-symptomatic carriers with a known genetic mutation linked to MND using targeted neuropsychological assessments and advanced multi-modal neuroimaging to track disease progression.